Abstract: A positive electrode active material and a preparation method thereof, a secondary battery, and an electric apparatus are provided. The positive electrode active material in the present invention includes: a core, where the core is a lithium-containing phosphate; a first coating layer disposed on at least part of surface of the core, where the first coating layer is a carbon coating layer co-doped with titanium and nitrogen; and a second coating layer disposed on at least part of surface of the first coating layer, where the second coating layer includes Li1+xMxTi2?x(PO4)3, where M is at least one element selected from aluminum, lanthanum, indium, zirconium, gallium, and scandium, and 0.2?x?0.8. With use of the positive electrode active material of the present invention, a high discharge capacity, excellent rate performance, and excellent cycling performance can be achieved.

Abstract: An antibody specifically binding to CTLA-4 or an antigen-binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule encoding the antibody or an antigen-binding fragment thereof, a vector and a host cell for expressing the antibody or an antigen-binding fragment thereof, and therapcutic and diagnostic methods and the use of the antibody or an antigen-binding fragment thereof.

Abstract: A terminal (UE 200) receives a temporary identifier and offset information in an initial access channel when using a second frequency band different from a first frequency band allocated for mobile communication. Also, the terminal (UE 200) converts the received temporary identifier into an identifier for communication in the second frequency band based on the offset information.

Abstract: Disclosed herein is an injectable depot formulation and use thereof for treating a mental disorder. The injectable depot formulation comprises cariprazine free base particles and a pharmaceutically acceptable carrier. The cariprazine free base particles have a median particle size by volume (Dv50) ranging from 0.5 ?m to 100 ?m.

Abstract: A high-efficiency cultivation method for high-frequency drip irrigation, water saving, seedling survival and strengthening, and yield increase of cotton fields in saline-alkali soil is provided, belonging to the field of agricultural planting technologies. It mainly includes performing land preparation; setting a planting mode; laying tubes; performing a high frequency drip irrigation; fertilizing with water; performing intertillage; performing chemical control; and performing green prevention and control. The method effectively solves many defects in the existing methods, improves the quality of cotton field preparation and seeding in saline-alkali soil, saves irrigation water, increases the emergence rate and seedling survival rate, improves the saline-alkali resistance of cotton seedlings, increases the yield, and achieves the goal of water-saving, high-quality and high-efficiency cultivation of cotton seedlings in saline-alkali soil.

Abstract: The present invention is directed to 3-(1H-imidazol-2-yl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one derivatives, stereoisomers, isotopologues, and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.

Abstract: The present disclosure provides an application of fish swim bladder-derived heparin-like mucopolysaccharide in the preparation of angiogenesis inhibitors, belonging to the technical field of medication. In the present disclosure, the structural unit of the fish swim bladder-derived heparin-like mucopolysaccharide is ?-?GlcUA-[1?3]-GalNAc-4S. The fish swim bladder-derived heparin-like mucopolysaccharide has strong inhibition on angiogenesis. As shown from the results of examples in the present disclosure, the inhibitory rate of 400 mg/L fish swim bladder-derived heparin-like mucopolysaccharide on the growth of human umbilical vein endothelial cells can be up to 90.3%; and the inhibitory rate of 1 mg/mL fish swim bladder-derived heparin-like mucopolysaccharide on the angiogenesis of chick embryo chorioallantoic membrane is 77.15%.

Abstract: The present invention provides an anti-ErbB2 antibody-drug conjugate, a composition comprising the conjugate, a method for preparing the conjugate, and use of the conjugate.

Abstract: A positioning model optimization method, a positioning method, and a positioning device are provided. The positioning model optimization method includes: inputting a positioning model for a scene, the positioning model including a three-dimensional (3D) point cloud and a plurality of descriptors corresponding to each 3D point in the 3D point cloud; calculating a significance of each 3D point in the 3D point cloud, and if the significance is greater than a predetermined threshold, outputting the 3D point and the plurality of descriptors corresponding to the 3D point to an optimized positioning model for the scene; and outputting the optimized positioning model for the scene.

Abstract: A method for preventing, alleviating and/or treating graft versus host disease caused by hematopoietic stem cell transplantation, which comprises administering an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound, metabolite or prodrug thereof to an individual in need thereof.

Abstract: The present invention discloses novel proinsulin glargine and method for for preparing insulin glargine therefrom. A sequence of the proinsulin glargine containing SOD fusion peptide subjected to site-directed mutagenesis and “0 C peptide” is designed; recombinant Escherichia coli for expressing insulin glargine are constructed; insulin glargine fusion protein in a form of an inclusion body is expressed; and denaturation, renaturation, modification, enzyme digestion, separation and purification are carried out to obtain a mature insulin glargine active pharmaceutical ingredient. According to the present invention, the SOD fusion peptide sequence is mutated to enhance the fermentation yield of the insulin glargine by 75%; and a “0 C peptide” strategy is adopted to reduce the quality loss and miscleavage impurities in the enzyme digestion transformation. The purity of the insulin glargine active pharmaceutical ingredient prepared in the present invention is up to 99.

Abstract: An abrasive article comprises: a substrate comprising strands forming first void spaces between strands; a laminate joined to the substrate, wherein the laminate comprises a surface opposite to the substrate; a resin composition joined to the surface of the laminate. First and second portions of the surface of the laminate have respective first and second surface free energies that are different. Another abrasive article comprises: a substrate comprising strands forming first void spaces between strands; a laminate joined to the substrate, wherein the laminate comprises a first polymer and a second polymer; a resin composition joined to the laminate; In both embodiments, abrasive particles are joined to the resin composition, and a plurality of second void spaces extends through the laminate coinciding with first void spaces in the porous substrate. A method of making abrasive articles is also disclosed.

Abstract: A wireless communication method for use in a wireless device is disclosed. The method comprises determining a hyper system frame number of a paging hyper-frame for a wireless terminal in an extended discontinuous reception, DRX, cycle based on at least one bit of an identifier of the wireless terminal, wherein the at least one bit is different from bits used for determining at least one of a system frame number of a paging frame or a paging occasion for the wireless terminal in a DRX cycle.

Abstract: Provided are a control signaling transmission method, a control signaling acquisition method, a device and a storage medium. The control signaling transmission method includes: sending, by a first communication node, first control information to a second communication node, where the first control information includes at least one downlink control information (DCI) sub-field, and the at least one DCI sub-field includes priority information.

Abstract: In a method of enabling an assist function, the assist function is enabled based on an execution history of a second operation that is to be performed by a virtual object in a virtual environment after a first operation is performed by the virtual object. The assist function is configured to automatically perform the second operation after the first operation. A first user input to perform the first operation by the virtual object is received. The second operation is automatically performed by the virtual object after the first operation is performed by the virtual object based on the assist function being enabled.

Abstract: An abrasive article comprises a porous substrate having openings extending through the porous substrate between first and second opposed major surfaces. An abrasive coating is disposed on only a portion of a first major surface of the porous substrate. The abrasive coating comprises a functional layer disposed on only a portion of a first major surface of the porous substrate, a make layer disposed on at least a portion of the functional layer opposite the porous substrate, and abrasive particles. The functional layer and the make layer independently comprise chemically crosslinked binders. The functional layer fully occludes a first portion the openings and does not fully occlude a second portion of the openings, which permits passage of abraded swarf through the abrasive article. Methods of making the abrasive article are also disclosed.

Abstract: Disclosed is a compound of a general formula (I), which may be used for the treatment of ATR kinase-mediated diseases, for example, proliferative diseases such as cancer. Further disclosed are a preparation method for the compound of the general formula (I), a pharmaceutical composition, and use of the pharmaceutical composition for the treatment of ATR kinase-mediated diseases.

Abstract: The invention discloses a semiconductor multi-station processing chamber. Each of the multiple station includes a downward concave accommodation defined by walls and receives a pedestal therein. The pedestal and the walls define a first gap. A showerhead plate mounted on an upper lid above the pedestal to define a processing region. A second gap for supply swiping gas is defined between the showerhead plate and the upper lid. An isolation member is liftable between the downward concave accommodation and the showerhead plate to optionally encircle a processing region defined by the pedestal and the showerhead plate or to retract back into the downward concave accommodation. Such that, when the isolation member surrounds and encircles the processing region, the station is able to be structurally isolated from its neighboring one station.

Abstract: An always on display method and an electronic device are provided. The method includes: An electronic device obtains text content. The electronic device performs word segmentation processing on the text content to obtain a plurality of word segments. The electronic device determines at least one layout format of the text content based on a quantity of words of the text content, a quantity of the plurality of word segments, and a preset mapping relationship. The at least one layout format includes a first layout format. The electronic device detects a screen lock operation. In response to the screen lock operation, the electronic device displays the text content on an always on display interface based on the first layout format.

Abstract: A refrigerator, comprising: a refrigerator body internally defining a storage space for storing articles, a door connected to the refrigerator body and used for opening and/or closing the storage space, and a microfluidic detection system which is provided on the door and comprises: a microfluidic biochip having a sample inlet, a communication port, and a detection pool formed in the microfluidic biochip, the sample inlet, the detection pool, and the communication port being connected in sequence by means of a microfluidic channel to allow a sample fluid in contact with the sample inlet to enter the microfluidic channel and flow into the detection pool by means of the microfluidic channel; and a detection mechanism used for detecting the detection pool after the sample fluid in the detection pool reacts with a detection reagent in the detection pool to obtain a preset detection parameter of the sample fluid.