Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: Systems, methods, and other embodiments for sorting-based assignment to optimize order fulfillment with short supply. One embodiment includes identifying a set of one or more distributions within a series of days. Sorting all demands of a first priority level occurring in the series of days by ascending order of size of the demand. For each demand of the first priority level in sorted order, (a) selecting an initial distribution during which the demand is scheduled to be fulfilled from the set of distributions, and (b) generating an indication that the demand can cannot be completely fulfilled, based on the size of the demand and the amount of supply available. Automatically arranging a graphical representation of a schedule of supplies and met and unmet demands for the series of days in a graphical user interface based at least on the indications generated for each demand.

Abstract: A detection device includes a frame, a transport mechanism, detection mechanisms, and a grasping mechanism. The transport mechanism includes a feeding line, a first flow line, and a second flow line arranged in parallel on the frame. The detection mechanisms are arranged on the frame and located on two sides of the transport mechanism. The grasping mechanism is arranged on the frame and used to transport workpieces on the feeding line to the detection mechanisms, transport qualified workpieces to the first flow line, and transport unqualified workpieces to the second flow line.

Abstract: Techniques are described for linked blockchains that allow computing devices to access information from an acceptance blockchain about acceptance reports stored in an enterprise delivery blockchain that are also linked to a product blockchain that stores information of the products of the acceptance reports. An acceptance report is indicative of operability of a product in a service provided by a service provider. A processor is configured to access the block in the enterprise delivery blockchain, retrieve the acceptance report from the block in the enterprise delivery blockchain, determine an identifier, identified in the block in the enterprise delivery blockchain, to a block in an acceptance blockchain, access the block in the acceptance blockchain via the determined identifier, retrieve from the block in the acceptance blockchain contextual information of the acceptance report, and output the acceptance report and contextual information of the acceptance report.

Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: A substrate includes a first doped region having a first type dopant, and a second doped region having a second type dopant and adjacent to the first doped region. A stack is formed that includes first layers and second layers alternating with each other. The first and second layers each have a first and second semiconductor material, respectively. The second semiconductor material is different than the first semiconductor material. A mask element is formed that has an opening in a channel region over the second doped region. A top portion of the stack not covered by the mask element is recessed. The stack is then processed to form a first and a second transistors. The first transistor has a first number of first layers. The second transistor has a second number of first layers. The first number is greater than the second number.

Abstract: A supported metallocene catalyst includes a carrier and a metallocene component. The carrier includes an inorganic oxide particle and an alkyl aluminoxane material. The inorganic oxide particle includes at least one inorganic oxide compound selected from the group consisting of an oxide of Group 3A and an oxide of Group 4A. The alkyl aluminoxane material includes an alkyl aluminoxane compound and an alkyl aluminum compound that is present in amount ranging from greater than 0.01 wt % to less than 14 wt % base on 100 wt % of the alkyl aluminoxane material. The metallocene component is supported on the carrier, and includes one of a metallocene compound containing a metal from Group 3B, a metallocene compound containing a metal from Group 4B, and a combination thereof. A method for preparing the supported metallocene catalyst and a method for preparing polyolefin using the supported metallocene catalyst are also disclosed.

Abstract: A grouped consensus power allocation method for multiple energy storage units is provided, including determining a grouped coordination control strategy of multiple battery energy storage units (BESUs) of a BESS (battery energy storage system), where the multiple BESUs are communicated through a communication topology and grouped into a charging group and a discharging group, performing power coordination control power coordination control between the charging group and the discharging group based on a distributed algorithm, determining whether a switching between the charging group and the discharging group is triggered during an operation process of the BESS, and switching when it is triggered. The method can reduce the number of charging/discharging state conversions of the BESUs, prolong the service life of energy storage, ensure that the power allocation results meet the power constraints of the BESUs, reduce low-power operation times of the BESUs, and improve the efficiency of energy storage operation.

Abstract: A method for providing driving assistance by detecting and warning against areas on one or other side of the road which are obscured by vehicles in other lanes is based on a HD map and includes acquiring location and driving speed of a vehicle which is carrying an apparatus applying the method. The system of the method includes at least one sensor, and environmental information as to surroundings is acquired with location. The speeds of other vehicles relative to the driving speed of the vehicle are calculated, and an instruction to the driver is generated the speed of the vehicle is less than a first predefined value but the speed of the vehicle relative to the driving speeds of the other vehicles is larger than a second predefined value. The apparatus applying the method is also disclosed.

Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.

Abstract: The present invention belongs to the technical field of membranes, and in particular relates to a polyamide composite reverse osmosis membrane and to a preparation method thereof. The polyamide composite reverse osmosis membrane provided by the present invention comprises: a nascent membrane and a temperature-responsive polypeptide grafted to a surface of the nascent membrane; the nascent membrane comprises a support layer and a polyamide separation layer joined to the support layer; the temperature-responsive polypeptide is a homopolymeric (L-glutamate) containing oligo(ethylene glycol). The polyamide composite reverse osmosis membrane provided in the present invention has excellent pollution resistance and oxidation resistance capabilities, has a low difficulty of cleaning, and has extremely broad market prospects.

Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.

Abstract: A method of giving early warning of a road section with abnormal driving conditions acquires own-driving information of multiple vehicles in a target region. The own-driving information is used for determining whether an abnormal road section is present. When the abnormal road section is present, a reason for the abnormal road section is confirmed based on images of the abnormal road section. The abnormal road section is determined and early warning given to all vehicles approaching the abnormal road section. A traffic early warning device and a computer readable storage medium applying the method are also disclosed.

Abstract: A method providing driving assistance based on a high-definition road map acquires information such as real time position of a vehicle, real time driving speed, and real-time information of upcoming road intersections. The intersection information includes traffic light information. Determinations as to whether the vehicle can safely pass through the intersection based on the real-time driving speed, and distances to and across the intersection are made, and it is also determined whether safe passage through the intersection is possible. An information intercommunication platform generates warnings to the vehicle being driven and other relevant when a crash is deemed likely between two vehicles, based on the determinations from the relevant vehicles which are in a specified range. A vehicle intercommunication system applying the method is also disclosed.

Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.

Abstract: The present invention provides an auxiliary wheel frame structure of motorcycle, which comprises a wheel frame, a block plate, and a wheel-frame controller. In the auxiliary wheel frame structure, the wheel-frame controller and the wheel frame are assembled to a chassis of a motorcycle. When the wheel-frame controller detects low-speed cruising of the motorcycle, the wheel-frame controller controls the wheel frame to descend. By using a first wheel and a second wheel of the wheel frame, the motorcycle still can be kept stable under low-speed cruising and hence improving riding safety for riders.

Abstract: A method for generating a random number, applied in a random number generator coupled to a flash memory is disclosed. the method comprises: selecting a plurality of cells from the flash memory; initializing the selecting cells of the flash memory; programming the selecting cells to obtain a plurality of first potential values of the selecting cells; re-initializing the selecting cells of the flash memory; re-programming the selecting cells to obtain a plurality of second potential values of the selecting cells; and processing the first potential values and the second potential values according to a predetermined algorithm to generating the random number.

Abstract: A method for providing driving assistance by detecting and warning against areas on one or other side of the road which are obscured by vehicles in other lanes is based on a HD map and includes acquiring location and driving speed of a vehicle which is carrying an apparatus applying the method. The system of the method includes at least one sensor, and environmental information as to surroundings is acquired with location. The speeds of other vehicles relative to the driving speed of the vehicle are calculated, and an instruction to the driver is generated the speed of the vehicle is less than a first predefined value but the speed of the vehicle relative to the driving speeds of the other vehicles is larger than a second predefined value. The apparatus applying the method is also disclosed.