Abstract: A system and method determines allergens which may present a risk of a respiratory attack to a user of the system. Historical data which precedes a respiratory attack is statistically analyzed. The data relates to the locations where the user has been present and includes environmental factors and optionally also human or animal contact factors. A location at which a respiratory attack is most likely to have been triggered is derived as well 5 as a set of most likely plant types (or animal types, mold or dust mites) to have caused the respiratory attack.

Abstract: A chip package structure is provided. The chip package structure includes a redistribution structure including a dielectric structure, a redistribution line, and a seal ring structure. The redistribution line and the seal ring structure are in the dielectric structure, the seal ring structure continuously surrounds the redistribution line, the seal ring structure includes a first seal ring and a second seal ring over and electrically connected to the first seal ring, and the redistribution structure has a first sidewall, a first surface, and a second surface opposite to the first surface. The chip package structure includes a chip structure over the first surface. The chip package structure includes a ground bump over the second surface. The chip package structure includes a conductive shielding film covering the chip structure and the first sidewall of the redistribution structure.

Abstract: The present invention relates to preparation and application of a cyclodextrin glucosyltransferase mutant, belonging to the fields of gene engineering and enzyme engineering. By mutating amino acids of cyclodextrin glucosyltransferase, the enzyme activity of the obtained mutant can reach 2.5 times that of wild enzyme. In addition, the cyclodextrin glucosyltransferase mutant obtained in the present invention is simple in purification and suitable for industrial production.

Abstract: The present disclosure discloses a maltooligosyl trehalose synthase mutant with improved thermal stability, and belongs to the technical fields of enzyme engineering and protein engineering. The residual enzyme activities of the MTSase mutants S361R, S444E, S361R/S444E, S361K/S444E, G415P/S361R/S444E and G415P consistent with the present disclosure after treatment at 60° C. for 10 min are respectively 70.3%, 50.1%, 83.5%, 65.9%, 100% and 80.7%, which are respectively 1.6, 1.1, 1.9, 1.5, 2.3 and 1.9 times of that of the wild type. The half-lives of the S361R/S444E and G415P/S361R/S444E at 60° C. are respectively 14.9 min and 90.8 min which are respectively 3.2 and 19.7 times of that of the wild type, indicating that the thermal stability of the MTSase mutant consistent with the present disclosure is significantly improved than that of the wild type.

Abstract: Methods of training machine learning models related to a patterning process, including a method for training a machine learning model configured to predict a mask pattern. The method including obtaining (i) a process model of a patterning process configured to predict a pattern on a substrate, wherein the process model comprises one or more trained machine learning models, and (ii) a target pattern, and training the machine learning model configured to predict a mask pattern based on the process model and a cost function that determines a difference between the predicted pattern and the target pattern.

Abstract: An electronic package is provided. The electronic package includes an encapsulating layer encapsulating a plurality of conductive pillars and an interposer board that has through-silicon vias. An electronic component is disposed on the encapsulating layer and electrically connected to the conductive pillars and the through-silicon vias. The conductive pillars act as an electric transmission path of a portion of electric functions of the electronic component. Therefore, the number of the through-silicon vias is reduced, and the fabrication time and chemical agent cost are reduced. Also, the through silicon interposer of a large area can be replaced by a smaller one, and the yield is increased. Further, a method of fabricating an electronic package is provided.

Abstract: A method including: obtaining data based an optical proximity correction for a spatially shifted version of a training design pattern; and training a machine learning model configured to predict optical proximity corrections for design patterns using data regarding the training design pattern and the data based on the optical proximity correction for the spatially shifted version of the training design pattern.

Abstract: Disclosed is an air purification system (10) comprising an air purifier apparatus (50) for removing a pollutant from air, a sensor (21, 23) for sensing a concentration of the air pollutant and a scent release apparatus (40) responsive to a scent release signal, wherein the air purification system further comprises a processor (31) adapted to monitor the pollutant concentration from sensor data received from the sensor and to generate the scent release signal upon the monitored pollutant concentration falling below a defined threshold. Also disclosed is a method of generating a scented atmosphere in a room housing an air purification apparatus (50) for removing a pollutant from the air in the room.

Abstract: Provided are a rapid detection method for a condition of landfill leachate polluting groundwater and an application thereof. The rapid detection method includes: carrying out fluorescence detection on groundwater in a specific region of a landfill, and determining whether the groundwater is polluted according to a ratio of fluorescence intensities at specific excitation/emission wavelengths in a specific fluorescence region. The rapid detection method provided by the solution establishes characteristic fluorescence spectrum regions, fluorescence intensities and regular characteristics thereof of organic matters in leachate-polluted groundwater of a landfill in a fluorescence spectrum region, and can achieve the rapid detection of a condition of landfill leachate polluting groundwater by means of a portable fluorescence detector on site. The detection method provided by the solution is characterized by rapid detection, no need of chemical reagents, simple operation, high detection sensitivity and lower cost.

Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes a gate stack formed over a semiconductor substrate, a source/drain contact structure laterally adjacent to the gate stack, and a gate spacer formed between the gate stack and the source/drain contact structure. The semiconductor device structure also includes a first insulating capping feature covering the upper surface of the gate stack, a second insulating capping feature covering the upper surface of the source/drain contact structure, and an insulating layer covering the upper surfaces of the first insulating capping feature and the second insulating capping feature. The second insulating capping feature includes a material that is different from the material of the first insulating capping feature. The semiconductor device structure also includes a via structure passing through the insulating layer and the first insulating capping feature and electrically connected to the gate stack.

Abstract: The present invention discloses a method for identifying fruit storability of apple fruit and a specific primer pair. The specific primer pair includes primers F and R; the primer F is a single-stranded DNA molecule depicted in SEQ ID No.1, and the primer R is a single-stranded DNA molecule depicted in SEQ ID No.2. It has been demonstrated that the specific primer pair can genotype ACS1 gene of an apple plant to further determine the fruit storability, decreasing costs of land, manpower and material resources. The present invention is of great importance in improving breeding efficiency and reducing breeding cost and has great application value in apple breeding.

Abstract: The present disclosure is related to a message processing method, which belongs to the field of information processing techniques. The message processing method includes: receiving a first request comprising a first resource identifier; determining whether the first resource identifier exists in a group resource comprising a plurality of second resource identifiers and group members corresponding to the second resource identifiers one by one; and sending the first request to other group member in the group resource than the group member corresponding to the first resource identifier when determining that the first resource identifier exists in the group resource.

Abstract: A chip package structure is provided. The chip package structure includes a chip structure. The chip package structure includes a first ground bump below the chip structure. The chip package structure includes a conductive shielding film disposed over the chip structure and extending onto the first ground bump. The conductive shielding film is electrically connected to the first ground bump.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes an insulating layer over a substrate, a gate stack formed in the insulating layer, and an insulating capping layer formed in the insulating layer to cover the gate stack. The semiconductor device structure also includes a source/drain contact structure adjacent to the gate stack. The source/drain contact structure has a sidewall that is in direct contact with a sidewall of the insulating capping layer, and an upper surface that is substantially level with an upper surface of the insulating capping layer and an upper surface of the insulating layer. In addition, the semiconductor device structure includes a first via structure above and electrically connected to the gate stack and a second via structure above and electrically connected to the source/drain contact structure.

Abstract: The present disclosure relates to a soup cooking control method for a pressure cooker, a pressure cooker, and a computer-readable storage medium. The method includes: a preheating and temperature-increasing stage, a medium-high temperature maintenance stage, a high pressure maintenance stage, and a decompression exhaust stage. The medium-high temperature maintenance stage includes: opening the pressure relief valve, to allow the pressure cooker to be in a non-closed state; controlling, under the non-closed state of the pressure cooker, the heating body to supply heat with a first preset heating power, and maintaining an internal temperature of the pressure cooker at a first preset temperature within a first preset duration. The present disclosure solves the problem that when the existing pressure cooker makes soup, insufficient oxidation of fat will cause large amounts of fat in the meat to dissolve, which affects people's health and the taste of the soup.

Abstract: A semiconductor device includes a substrate, a first gate structure and a second gate structure over the substrate, a first hard mask on a top surface of the first gate structure, a second hard mask on the second gate structure and a third hard mask disposed between the first gate structure and the second gate structure and disposed between the first hard mask and the second hard mask. A bottom surface of the third hard mask is substantially flush with a bottom surface of the first gate structure.

Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.

Abstract: Disclosed are a class of ?-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The ?-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

Abstract: A method for determining the position of a mobile node applied to a roadside unit (RSU) is provided. The RSU and a plurality of mobile nodes form a communication network of a road. The method includes the steps of: obtaining, by, via at least one sensor, first road information, wherein the first road information provides absolute position distribution information associated with the mobile nodes; receiving, by a communication device, second road information from a first mobile node of the mobile nodes, wherein the second road information provides relative position distribution information associated with the first mobile node and second mobile nodes adjacent to the first mobile node; and determining, by a comparison device, the position of the first mobile node on the road according to the first road information and the second road information.