Abstract: The present disclosure provides an IL-10 variant protein, a fusion protein comprising the IL-10 variant protein and a polypeptide, and the use thereof. The present disclosure also provides a method of producing the same and a pharmaceutical composition comprising the same.

Abstract: The present disclosure provides antibodies, including antibody fusions, which specifically bind to human CSF1 receptor protein (huCSF1R) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by huCSF1R, such as regulation of TAMs in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+ T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CSF1 binding to CSF1R.

Abstract: The present disclosure provides antibodies, including antibody fusions, which specifically bind to human CSF1 receptor protein (huCSF1R) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by huCSF1R, such as regulation of TAMs in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CSF1 binding to CSF1R.

Abstract: Provided is an anti-INF-? antibody. Also provided are a composition comprising the antibody and a pharmaceutical application of the antibody in treating IFN-? mediated syndrome.

Abstract: Provided is an anti-INF-? antibody. Also provided are a composition comprising the antibody and a pharmaceutical application of the antibody in treating IFN-? mediated syndrome.

Abstract: Provided is an anti-INF-? antibody. Also provided are a composition comprising the antibody and a pharmaceutical application of the antibody in treating IFN-? mediated syndrome.

Abstract: Provided is an anti-INF-? antibody. Also provided are a composition comprising the antibody and a pharmaceutical application of the antibody in treating IFN-? mediated syndrome.

Abstract: Disclosed are methods and compositions useful in preventing or treating a disease related to muscle wasting by using acidic fibroblast growth factor (aFGF).

Abstract: A portable device and a method for entering a power-saving mode are provided. Audio stream is generated by an audio player, and an audio signal is generated according to the audio stream and then transmitted to an earphone via a cable by a digital-analog converter. At least one electrical characteristic on the cable is sensed to generate at least one sensing signal. The at least one sensing signal is sampled to generate at least one data signal. Whether the earphone is inserted into an ear canal is determined according to the at least one data signal. For determining whether the earphone is inserted into the ear canal, an impedance frequency response related to the earphone is obtained according to the at least one data signal, and whether the earphone is inserted into the ear canal is determined according to a characteristic of peaks of the impedance frequency response.

Abstract: A portable device and a method for entering a power-saving mode are provided. An audio signal is transmitted to an earphone via a cable. At least one electrical characteristic on the cable is sensed to generate at least one sensing signal. The at least one sensing signal is sampled to generate at least one data signal. Whether the earphone is in listening position is determined according to the at least one data signal. When it is determined that the earphone is not in listening position, the portable device enters a power-saving mode.

Abstract: A portable device and a method for entering a power-saving mode are provided. An audio signal is transmitted to an earphone via a cable. At least one electrical characteristic on the cable is sensed to generate at least one sensing signal. The at least one sensing signal is sampled to generate at least one data signal. Whether the earphone is in listening position is determined according to the at least one data signal. When it is determined that the earphone is not in listening position, the portable device enters a power-saving mode.

Abstract: A measurement method, a measurement apparatus, and a computer program product for measuring a thermoelectric module are provided. A temperature is provided to the thermoelectric module. A current is applied to the thermoelectric module to turn both sides of the thermoelectric module into a hot side and a cold side. The temperature of the hot side is higher than that of the cold side. A terminal voltage of the thermoelectric module, a hot side temperature of the hot side, and a cold side temperature of the cold side are measured at different time points. A thermoelectric relationship between the terminal voltages and differences between the hot side temperatures and the corresponding cold side temperatures is obtained according to the terminal voltages, the hot side temperatures, and the cold side temperatures. At least one first parameter of the thermoelectric module is estimated according to the thermoelectric relationship.

Abstract: A multi-layer thermoelectric module and a fabricating method thereof are provided. The module includes two thermoelectric element sets and a metal electrode set, in which the thermoelectric element sets are corresponding to different operating temperature ranges. Each thermoelectric element set includes a thermoelectric unit, an interfacial adhesion layer, a diffusion barrier layer and a high melting-point metal layer. In the method, the thermoelectric unit, the interfacial adhesion layer, and the diffusion barrier layer are sequentially formed on the thermoelectric unit. Then, two high melting-point metal layers are formed respectively on the electrode layers of the metal electrode set.

Abstract: A multi-layer thermoelectric module and a fabricating method thereof are provided. The module includes two thermoelectric element sets and a metal electrode set, in which the thermoelectric element sets are corresponding to different operating temperature ranges. Each thermoelectric element set includes a thermoelectric unit, an interfacial adhesion layer, a diffusion barrier layer and a high melting-point metal layer. In the method, the thermoelectric unit, the interfacial adhesion layer, and the diffusion barrier layer are sequentially formed on the thermoelectric unit. Then, two high melting-point metal layers are formed respectively on the electrode layers of the metal electrode set.

Abstract: An asynchronous master-slave serial communication system, a data transmission method, and a control module using the same are disclosed. The asynchronous master-slave serial communication system comprises a master control module and a slave control module. The master control module generates a check code according to an address information and a data information, and generates a data package according to the address information, the data information, the check code and the master clock signal. The slave control module generates a decoding data according to the data package and a slave clock signal, and generates the address information, the data information and the check code according to the decoding data.

Abstract: A real-time sampling device for being coupled to a processing unit includes a first register, a second register, a third register, a trigger output element and a timer for outputting an interrupt signal. The first register externally receives and processes a first input signal to produce processed data. The second register retrieves the processed data from the first register upon receiving the interrupt signal, and the processing unit, upon receiving the interrupt signal, retrieves the processed data from the second register and performs calculation thereon to produce a processed data calculation value and temporarily store the processed data calculation value in the third register. The trigger output element outputs the processed data calculation value in the third register in real time upon receiving the interrupt signal. The real-time sampling device an be applied to digital control systems in order to perform real-time sampling on controlled subjects.

Abstract: A measurement method, a measurement apparatus, and a computer program product for measuring a thermoelectric module are provided. A temperature is provided to the thermoelectric module. A current is applied to the thermoelectric module to turn both sides of the thermoelectric module into a hot side and a cold side. The temperature of the hot side is higher than that of the cold side. A terminal voltage of the thermoelectric module, a hot side temperature of the hot side, and a cold side temperature of the cold side are measured at different time points. A thermoelectric relationship between the terminal voltages and differences between the hot side temperatures and the corresponding cold side temperatures is obtained according to the terminal voltages, the hot side temperatures, and the cold side temperatures. At least one first parameter of the thermoelectric module is estimated according to the thermoelectric relationship.

Abstract: An asynchronous master-slave serial communication system, a data transmission method, and a control module using the same are disclosed. The asynchronous master-slave serial communication system comprises a master control module and a slave control module. The master control module generates a check code according to an address information and a data information, and generates a data package according to the address information, the data information, the check code and the master clock signal. The slave control module generates a decoding data according to the data package and a slave clock signal, and generates the address information, the data information and the check code according to the decoding data.

Abstract: A method of text script generation for a corpus-based text-to-speech system includes searching in a source corpus having L sentences, selecting N sentences with a best integrated efficiency as N best cases, and setting iteration k to be 1; for each case n of the N best cases, selecting Mk+1 best sentences with the best integrated efficiency from the unselected sentences in the source corpus; keeping N best cases out of the total unselected sentences for next iteration, and increasing iteration k by 1; and if a termination criterion being reached, setting the best case in the N traced cases as the text script, otherwise, returning to the (k+1)th iteration of searching in the unselected sentences for (k+1)th sentence; wherein the best integrated efficiency depends on a function of combining the covering rate of the synthesis unit type, the hit rate of the synthesis unit type, and the text script size.

Abstract: A motion control servo loop apparatus, comprising: a feed-forward control module, and a proportional-integral-derivative (PID) control loop and a compensation adder. The feed-forward control module is capable of generating a feed-forward compensation. The PID control loop further comprises: a proportional control module, an integral control module and a derivative control module. The proportional control module is capable of generating a proportional compensation. The derivative control module is capable of generating a derivative compensation. The integral control module uses a digital differential analyzer (DDA) algorithm to perform integration for accumulated errors with respect to each sampling clock at each DDA pulse and thus output an accumulated error, which is then processed to generate an integral compensation.