Abstract: Cannabidiol derivatives and medical use thereof, in particular to the compounds represented by general formula (I), or stereoisomers, solvates, metabolites, prodrugs, pharmaceutically acceptable salts or cocrystals thereof, wherein the definitions of substituents in general formula (I) are the same as those in the description

Abstract: A display screen lighter and a display screen detection device are provided.

Abstract: A battery cell may comprise: an electrode assembly, a housing and an end cap. The electrode assembly may have a first tab. The housing may have an opening for accommodating the electrode assembly. The end cap may be configured to connect with the housing and cover the opening. The end cap may have an abutting surface and a welding groove, the abutting surface may be configured to abut against the first tab, and the welding groove may be recessed from one side of the end cap away from the electrode assembly towards the abutting surface. The end cap may form a connector between the abutting surface and the bottom surface of the welding groove, and the connector is configured for being welded with the first tab. The end cap is provided with a reinforcing structure, and the reinforcing structure is protruded from the bottom surface.

Abstract: Methods and systems for performing diagnostic functions for a deep learning model are provided. One system includes one or more components executed by one or more computer subsystems. The one or more components include a deep learning model configured for determining information from an image generated for a specimen by an imaging tool. The one or more components also include a diagnostic component configured for determining one or more causal portions of the image that resulted in the information being determined and for performing one or more functions based on the determined one or more causal portions of the image.

Abstract: Methods and systems for accelerated training of a machine learning based model for semiconductor applications are provided. One method for training a machine learning based model includes acquiring information for non-nominal instances of specimen(s) on which a process is performed. The machine learning based model is configured for performing simulation(s) for the specimens. The machine learning based model is trained with only information for nominal instances of additional specimen(s). The method also includes re-training the machine learning based model with the information for the non-nominal instances of the specimen(s) thereby performing transfer learning of the information for the non-nominal instances of the specimen(s) to the machine learning based model.

Abstract: A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target.

Abstract: A simulation system performs microsimulations to model the impact of one or more early cancer detection screenings for a plurality of participants to simulate a randomized controlled trial (RCT). In one instance, the microsimulations are performed using parallel processing techniques. The microsimulation simulates the impact of early detection screenings on individual trajectories of the participants. In particular, while most screening modalities are for single cancer types, the microsimulation herein simulates the effect of a detection model on individual trajectories for participant populations having multiple types of cancer using, for example, multi-cancer early detection (MCED) screenings that are capable of detecting multiple types of cancer.

Abstract: Crystalline forms of upadacitinib and processes for preparation thereof are disclosed. The present disclosure also relates to pharmaceutical compositions containing the upadacitinib crystalline forms, use of the upadacitinib crystalline forms for preparing JAK1 inhibitor drugs, and use of the upadacitinib crystalline forms for preparing drugs treating rheumatoid arthritis, Crohn's disease, ulcerative colitis, atopic dermatitis and psoriatic arthritis. The crystalline forms of upadacitinib provided by the present disclosure have one or more improved properties compared with prior arts and have significant values for future drug optimization and development.

Abstract: A PEGylated ICD inducer-IDO inhibitor nanoconjugate and a preparation method and use thereof. The nanoconjugate has a structural formula as follows: where R is H or with a weight-average molecular weight of 1000-5000. For the PEGylated ICD inducer-IDO inhibitor nanoconjugate provided in an aqueous medium, the PEGylated drug conjugate can self-assemble into a drug-based nanoconjugate, which can not only reduce non-specific accumulation in MPS-related organs, but also improve the passive targeting capability to solid tumors through the enhanced permeability and retention effect, thereby increasing the therapeutic index.

Abstract: A display panel, a driving method for a display panel, and a display device are provided. The display panel includes a functional component area, a display area at least partially surrounding the functional component area, a first non-display area between the functional component area and the display area, a second non-display area at least partially surrounding the display area, a touch-control electrode layer, and touch-control signal lines. The touch-control electrode layer includes a plurality of touch-control electrode blocks. The touch-control signal lines are electrically connected to the plurality of touch-control electrode blocks correspondingly. At least one touch-control signal line of the touch-control signal lines is multiplexed as crack detection lines. At least a portion of the crack detection lines is located in the first non-display area and surrounding the functional component area.

Abstract: A display panel and a display device are provided. The display panel includes a display area, a light transmission area, a first frame area, a crack detection line in the first frame area, and two first connection lines. The first frame area surrounds the light transmission area and the display area surrounding the first frame area. At least a portion of the crack detection line extends along a circumferential direction of the light transmission area. The crack detection line is connected to the two first connection lines. Each first connection line of the two first connection lines includes a first end connected to the crack detection line and a second end away from the first end. A distance between two first ends of the two first connection lines is larger than a distance between two second ends of the two first connection lines.

Abstract: In an approach, a processor identifies a plurality of text separators in a borderless table, a text separator of the plurality of text separators defining a non-text region between two consecutive text lines in the borderless table. A processor classifies the plurality of text separators into a number of target clusters comprised in a target group based on property information related to the plurality of text separators, the number of target clusters corresponding to a number of separator types. A processor provides indication information to indicate respective separator types of the plurality of text separators based on a result of the classifying.

Abstract: Methods and systems for learnable defect detection for semiconductor applications are provided. One system includes a deep metric learning defect detection model configured for projecting a test image for a specimen and a corresponding reference image into latent space, determining a distance in the latent space between one or more different portions of the test image and corresponding portion(s) of the corresponding reference image, and detecting defects in the one or more different portions of the test image based on the determined distances. Another system includes a learnable low-rank reference image generator configured for removing noise from one or more test images for a specimen thereby generating one or more reference images corresponding to the one or more test images.

Abstract: The present invention concerns a reservoir assembly for use in three-dimensional (3D) printing for building a 3D object, which includes a top frame that may be filled with liquid material, and a tensioned film being held underneath the top frame. The tensioned film may be air permeable and elastic at the same time, wherein surfaces of the tensioned film are micro textured so that the tensioned film becomes optically clear when it contacts with the liquid material. The tensioned film minimizes the creation of bubbles between the top and bottom surfaces. This also helps blurring the boundaries thereby enhancing the surface finish of the fabricated parts.

Abstract: The present application belongs to a technical field of modifying natural polymer materials, provides a high-viscosity lithium carboxymethyl cellulose and preparation method therefor and application thereof. Raw materials are fed into a reactor, and the high-viscosity lithium carboxymethyl cellulose is prepared through an alkalization reaction, an etherification reaction, an acidification reaction and a substitution reaction. The prepared high-viscosity lithium carboxymethyl cellulose can be used for preparing a negative electrode plate of a lithium-ion battery. Compared with the existing lithium carboxymethyl cellulose, the high-viscosity lithium carboxymethyl cellulose provided by the present application can not only reduce an application amount in preparing a negative electrode plate of a lithium-ion battery so as to save a using cost, but also promote an electrochemical performance of the material in combination with a sodium lignin sulfonate.

Abstract: A coated abrasive article is presented. The coated abrasive article includes a backing having first and second opposed major surfaces. The coated abrasive article also includes a make layer bonded to the first major surface. The coated abrasive article also includes abrasive particles directly bonded to the make layer. The abrasive particles are at least partially embedded in the make layer. The coated abrasive article also includes a size layer directly bonded to the make layer, and abrasive particles. One of the make layer and size layer comprise a patterned coating.

Abstract: Cannabidiol derivatives and medical use thereof, in particular to compounds represented by general formula (I), or stereoisomers, solvates, metabolites, pharmaceutically acceptable salts or cocrystals thereof, wherein the definitions of the substituents in general formula (I) are the same as those in the description.

Abstract: An abrasive article is disclosed. The abrasive article has a backing substrate. The abrasive article also has a laminate joined to the backing substrate. The laminate comprises a hot melt polymer. The abrasive article also has a cured resin composition joined to the laminate opposite the backing substrate. The abrasive article also has abrasive particles joined to the cured resin composition.

Abstract: The present disclosure a leak-proof lost-circulation control water-based drilling fluid composition and preparation method and use thereof.

Abstract: A heat dissipation device for an LED light strip of a television is provided, including a heat dissipation substrate and a heat dissipation plate. A mounting surface of the heat dissipation substrate is provided with a clamping opening for mounting the light strip and a mounting groove extending along a length direction. The light strip may be arranged on the mounting surface along the length direction through the clamping opening. The heat dissipation plate is filled with a refrigerant working medium, one side of the heat dissipation plate is fixed in the mounting groove, and the heat dissipation plate extends along the length direction of the heat dissipation substrate.