Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Abstract: A fluid regulator includes an actuator assembly disposed in a valve body. A sleeve includes a cylindrical wall, a first plate, and a second plate. Each of the first plate and the second plate is disposed in a cavity of the sleeve. A stem extends through the sleeve and is axially aligned with a longitudinal axis of the body, and includes a passage extending partially through the stem. The actuator assembly includes first and second pistons. First, second, third, and fourth chambers are separately disposed between the sleeve, the first or second plate, or the first or second piston. The first and third chambers are in fluid communication, and the second and fourth chambers are in fluid communication via the passage of the stem. The actuator assembly actuates a control element in response to a fluid pressure receivable in the first, second, third, and/or fourth chambers.

Abstract: A cleaning method of a semiconductor structure is provided. The method includes providing a substrate, where the substrate includes a functional surface and a back surface that is opposite to the functional surface. The method also includes forming a fluid passivation film on the functional surface of the substrate. In addition, the method includes after forming the fluid passivation film, performing a first charge removal treatment on the functional surface of the substrate through a wet cleaning process. Further, the method includes after performing the first charge removal treatment, performing a main cleaning treatment on the functional surface and the back surface of the substrate.

Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, m and n are as defined in the specification, with an inhibitory effect of PD-L1 expression and an inhibitory effect of reduced production of IL-2 and a medicament useful for the treatment of a disease associated with the reduced immune function caused by the formation of PD-1/PD-L1 binding.

Abstract: Provided is an empathy evaluation method and apparatus using video characteristics information. The empathy evaluation method includes establishing a video database by collecting a plurality of video clips, classifying and labeling each of the video clips by empathy, preparing training data by extracting a region of interest (ROI) video from each of the video clips and extracting physical characteristics from the ROI video, generating a video characteristics model file obtained through learning using the training data include 2 labels(empathy/non-empathy) vector that is calculated by the difference between the metric measurement size trained with respect to the video characteristics. Test video into the system can automatically judge the empathy evaluation of video.

Abstract: The present invention belongs to the field of agricultural acaricides, and particularly relates to a trifluoroethyl thioether (sulfoxide) substituted benzene compound and use thereof. The compound has a structure as shown in general formula I: The definition of each substituent in the formula is described in the specification. The compound of general formula I has excellent acaricidal activity and can be used to prevent and control various pest mites.

Abstract: A system for detecting an anomaly in an execution of an operation of a machine determines a local matrix profile (LMP) of a test signal with respect to the baseline signals. LMP is a time series of values, each LMP value for a time instance is determined for a segment of the test signal based on a minimum distance between the segment of the test signal with corresponding segments of the baseline signals, such that each LMP value is a value of a local dissimilarity of the execution of the operation of the machine with respect to the baseline executions of the operation of the machine. The system determines an accumulation of the LMP values above an LMP threshold and detects an anomaly when the accumulation above an anomaly detection threshold.

Abstract: A fine-displacement adjusting device is constructed to have a first base portion and a second base portion spacedly encircled therewithin. The fine-displacement adjusting device further includes a first retractable element biased between the first and second base portions, and a first resilient element biased between the first and second base portions. The first retractable element is configured to extend and retract its length along a first axis to move the second base portion in a reciprocating manner. When the second base portion is moved by the first retractable element, the first resilient element moves the second base portion along the first axis to restore the second base portion. Therefore, the second base portion is fine-moved along the first axis in a reciprocating manner for adjusting the fine-displacement of an optical lens relative to an optical light source of a light engine in the first axis.

Abstract: The present disclosure provides a method and system for earthquake disaster level assessment. The method includes: obtaining earthquake disaster information at an initial stage of an earthquake; determining a casualty assessment model based on an epicentral intensity as a core factor, an earthquake magnitude, a seismic intensity, an earthquake origin time, and a population density in a seismic area; determining an earthquake economic loss assessment model based on the earthquake magnitude, the seismic intensity, and gross domestic product (GDP) per capita; establishing an earthquake disaster level assessment model based on the casualty assessment model and the earthquake economic loss assessment model; and determining an earthquake disaster level based on the earthquake disaster level assessment model and initiating an emergency response based on the earthquake disaster level. The present disclosure can quickly assess an earthquake disaster level and initiate an emergency response.

Abstract: A wastewater treatment device has: an ozone generator which supplies ozone; a mixer which mixes ozone supplied from the ozone generator with wastewater and supplies ozone mixed wastewater; an ozone oxidation unit which progresses ozone oxidation in the ozone mixed wastewater while passing the ozone mixed wastewater therethrough and discharges wastewater in which the ozone has been consumed; a biological treatment unit which performs biological treatment on the wastewater discharged from the ozone oxidation unit using microorganisms; and an adjusting device which adjusts the amount of ozone to be mixed with the wastewater by the mixer so that ozone in an amount that inhibits the microorganisms of the biological treatment unit does not remain in the wastewater discharged from the ozone oxidation unit.

Abstract: The disclosure relates to an abrasive article comprising: a fabric substrate comprising strands forming first void spaces between the strands; a laminate joined to the fabric substrate; a cured resin composition joined to the laminate opposite the fabric substrate; abrasive particles joined to the cured resin composition; and a plurality of second void spaces extending through the laminate coinciding with first void spaces in the fabric substrate. The disclosure also relates to methods of making such abrasive articles.

Abstract: The present subject matter relates to a fluorescent compound having aggregation-induced emission (AIE) characteristics. The compound can undergo spontaneous hierarchical self-assembly from a vesicle to a helical fiber in the aggregate state. A composition capable of providing circularly polarized luminescence can include the fluorescent compound and at least one additional compound selected from the group consisting of an aggregation-caused quenching luminogen and an aggregation-induced emission luminogen.

Abstract: Systems of the present disclosure generate database queries for financial information requested in a natural-language form. A natural-language processing (NLP) financial aggregator receives a request for financial information and extracts NLP features of the request, including keywords. The NLP financial aggregator determines a type of the request based on the features and creates a query in a database-query language for the financial information based on the type and on the features. The NLP financial aggregator submits the query to a database where the financial information is stored. The software then receives the financial information from the database and sends the information to the user.

Abstract: A touch panel, a method for testing the touch panel and a display device are provided. In order to test the touch panel, all touch electrodes are connected in series to obtain a branch during the testing phase, a test signal is inputted to the branch, and a feedback signal outputted by the branch is analyzed for determination. All the touch electrodes are isolated from each other during a phase rather than the testing phase. Therefore, whether a touch electrode is abnormal is determined by controlling all the touch electrodes to be connected in series during the testing phase and isolated from each other during the phase rather than the testing phase, to improve efficiency for testing a touch electrode and simplifying the process of testing the touch electrode.

Abstract: A disclosed apparatus may be a circuit board that includes (1) a first unique sublaminate that includes a plurality of ground layers and a plurality of signal layers, (2) a second unique sublaminate that includes a plurality of power layers and another plurality of signal layers, and (3) a symmetry axis that bisects the circuit board between the first unique sublaminate and the second unique sublaminate, wherein the first unique sublaminate and the second unique sublaminate are distinct from one another. Various other apparatuses, systems, and methods are also disclosed.

Abstract: The present disclosure discloses a gold/quantum dot nanoprobe for detecting active ricin in a complex matrix and application thereof. The gold/quantum dot nanoprobe is a nanoprobe formed by utilizing gold nanoparticles and quantum dots, which are modified by single strand oligodeoxynucleotides (ssODN), to form double strand oligodeoxynucleotides in a base pairing hybridizing mode and assembling the gold nanoparticles and the quantum dots into a core-satellite structure. According to the present disclosure, the gold/quantum dot nanoprobe is used for detecting the active ricin, has a limit of detection of 7.46 ng/mL, is high in accuracy and good in reliability, and does not require large-scale equipment and complex operations. In order to further eliminate the false positive result, the present disclosure further provides a method for enriching ricin in a complex sample by utilizing magnetic beads.

Abstract: A method and device for preventing impact vibration of a lift system include: acquiring a load weight in a lift container; obtaining preset basic parameters of a lift system; according to the load weight in the lift container and the basic parameters of the lift system, determining a fundamental wave vibration period of a lifting rope when the lift system starts; according to the fundamental wave vibration period and preset calculation parameters of the lift system, determining time-varying simulation parameters of an acceleration of the lift system during a lifting process; according to determined time-varying simulation parameters of the acceleration, lifting the lift container.

Abstract: A multi-loop natural circulation experimental device under six-degree-of-freedom motion conditions and a method therefor are provided. The device includes: a six-degree-of-freedom motion simulation platform; a multi-loop main circulation loop including a serpentine pre-heater, an experimental section, two sleeve-type condensers, and a pressurized circulating pump, a voltage stabilizer and related equipment; and a cooling water system including a sleeve condenser, a plate heat exchanger, a cooling tower, a cooling fan, a cooling water tank and related equipment; and an electric heating system including a DC power supply, a low voltage power controller and a transformer. The present invention also provides an experimental method of the device.

Abstract: A display screen lighter and a display screen detection device are provided.