Publication number: 20250108106
Abstract: This disclosure is directed to a pharmaceutical composition for treating or preventing a disease. The pharmaceutical composition can comprise a polymer-drug nanoaggregate having a polymer and at least one bioactive agent that can comprise STING polypeptide, a nucleic acid encoding said STING polypeptide, a STING inhibitor, a STING activator, a STING agonist, a STING antagonist, a STING modulating molecule, or a combination thereof. The pharmaceutical composition can be a vaccine or an adjuvant for a vaccine. This disclosure is also directed to a method for treating or preventing a disease using the pharmaceutical composition. The disease can include infectious diseases caused by viruses or other pathogens, for example, influenza, rabies, or respiratory illnesses such as severe acute respiratory syndrome (SARS) caused by coronaviruses, such as MERS-CoV, SARS-CoV, and Coronavirus Disease 2019 (COVID-19) caused by the virus SARS-CoV-2 and its variants.
Type:
Application
Filed:
September 10, 2024
Publication date:
April 3, 2025
Inventors:
Lu Lu, Ray Yin, Shibo Jiang, Zezhong Liu, Ming Hsieh, Jie Zhou, Xinling Wang, Qian Wang, Wei XU, Jing Pan, Yubei Zhang, Kai Qi, Qun Sun, Lin Wang, Zhiying Zou, Chunlin Tao