Patents by Inventor Jingwei Xie
Jingwei Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210338408Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: June 25, 2021Publication date: November 4, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20210268154Abstract: Three dimensional nanofiber structures are provided and methods of production thereof.Type: ApplicationFiled: May 11, 2021Publication date: September 2, 2021Inventors: Jingwei Xie, Jiang Jiang
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Publication number: 20210267746Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: ApplicationFiled: April 13, 2021Publication date: September 2, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 11096772Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: GrantFiled: April 13, 2021Date of Patent: August 24, 2021Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 11071617Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: GrantFiled: October 6, 2020Date of Patent: July 27, 2021Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20210212949Abstract: Nanofiber segments and nanofiber microspheres are provided as well as methods of use thereof and methods of making.Type: ApplicationFiled: April 23, 2019Publication date: July 15, 2021Inventors: Jingwei Xie, Sunil Kumar Boda
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Patent number: 11033659Abstract: Three dimensional nanofiber structures are provided and methods of production thereof.Type: GrantFiled: September 29, 2015Date of Patent: June 15, 2021Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Jiang Jiang
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Patent number: 11000358Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: GrantFiled: September 13, 2018Date of Patent: May 11, 2021Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20210052362Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: October 27, 2020Publication date: February 25, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20210030525Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: October 6, 2020Publication date: February 4, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 10888409Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: GrantFiled: February 19, 2020Date of Patent: January 12, 2021Assignee: WASHINGTON UNIVERSITYInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 10799620Abstract: Nanofiber structures are provided along with methods of production and methods of use.Type: GrantFiled: July 21, 2017Date of Patent: October 13, 2020Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Shixuan Chen, Bernard Timothy Baxter
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Publication number: 20200277711Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.Type: ApplicationFiled: September 19, 2018Publication date: September 3, 2020Inventor: Jingwei Xie
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Publication number: 20200197153Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: February 19, 2020Publication date: June 25, 2020Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20200164107Abstract: Cell-containing expanded, nanofiber structures are provided as well as methods of use thereof, particularly for wound healing.Type: ApplicationFiled: June 8, 2018Publication date: May 28, 2020Inventors: Jingwei Xie, Shixuan Chen, Mark Carlson
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Patent number: 10617512Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: GrantFiled: August 14, 2019Date of Patent: April 14, 2020Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 10588734Abstract: A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a flexible deposited fiber network of varying density including a first and second set of set of electrospun fibers. The second set of electrospun fibers is coupled to the first. A first portion of the flexible deposited fiber network includes a higher density of fibers than a second portion of the flexible deposited fiber network, and the tensile strength of first portion is higher than that of the second portion. The scaffold is sufficiently flexible to facilitate application of scaffold to uneven surfaces of the tissue substrate, and enables movement of the scaffold by the tissue substrate. The first and second set of fibers are configured to degrade within three months after application, and each fiber of the deposited fiber network has a diameter of 1-1000 nanometers.Type: GrantFiled: August 14, 2019Date of Patent: March 17, 2020Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20200000570Abstract: A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a flexible deposited fiber network of varying density including a first and second set of set of electrospun fibers. The second set of electrospun fibers is coupled to the first. A first portion of the flexible deposited fiber network includes a higher density of fibers than a second portion of the flexible deposited fiber network, and the tensile strength of first portion is higher than that of the second portion. The scaffold is sufficiently flexible to facilitate application of scaffold to uneven surfaces of the tissue substrate, and enables movement of the scaffold by the tissue substrate. The first and second set of fibers are configured to degrade within three months after application, and each fiber of the deposited fiber network has a diameter of 1-1000 nanometers.Type: ApplicationFiled: August 14, 2019Publication date: January 2, 2020Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20190365520Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: August 14, 2019Publication date: December 5, 2019Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20190209732Abstract: Coated and expanded, nanofiber structures are provided and methods of use thereof.Type: ApplicationFiled: September 28, 2017Publication date: July 11, 2019Inventors: Jingwei Xie, Shixuan Chen, Mark Carlson