Patents by Inventor Jinjun Shi

Jinjun Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11123304
    Abstract: This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia): and a repeating unit of Formula (Ib): wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 21, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Omid C. Farokhzad, Jun Wu, Xi Zhu, Jinjun Shi
  • Patent number: 11090367
    Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: August 17, 2021
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Jinjun Shi, Mohammad Ariful Islam, Yingjie Xu, Omid C. Farokhzad, Bruce Zetter
  • Publication number: 20210091420
    Abstract: Battery packs according to embodiments of the present technology may include a first battery cell including a lithium-containing material. The first battery cell may be configured to operate in a voltage window extending to or above about 4 V. The battery packs may include a second battery cell electrically coupled in parallel with the first battery cell. The second battery cell may be configured to operate in a voltage window maintained at or below about 4.0 V. The battery packs may also include a controller configured to receive a measured terminal voltage from the first battery cell. The controller may be configured to determine whether to disconnect the second battery cell from the first battery cell based on the measured terminal voltage of the first battery cell.
    Type: Application
    Filed: September 20, 2019
    Publication date: March 25, 2021
    Applicant: Apple Inc.
    Inventors: Dapeng Wang, Jinjun Shi, Norberto N. Ison
  • Publication number: 20210043881
    Abstract: Batteries according to embodiments of the present technology may include an enclosure. The batteries may include an electrode stack including a separator positioned between an anode and a cathode. The electrode stack may be characterized by a first side from which a plurality of electrode tabs extend, a second side opposite the first, a third side, and a fourth side opposite the third. The batteries may also include a wrapping seated on a first surface of the electrode stack and extending beyond an edge of each of the second, the third, and the fourth sides of the electrode stack a distance equal to or greater than a thickness of the electrode stack. The wrapping may be adhered to a second surface of the electrode stack opposite the first surface of the electrode stack on each of the second side, the third side, and the fourth side of the electrode stack.
    Type: Application
    Filed: August 3, 2020
    Publication date: February 11, 2021
    Applicant: Apple Inc.
    Inventors: Dapeng Wang, Sang Young Yoon, Jinjun Shi
  • Publication number: 20200403279
    Abstract: The disclosed technology relates to battery packs having battery cells of different designs or capacities with an imbalance in the charging and/or discharging current supplied to and provided by each jelly roll due to differences in capacity specific impedance between the battery cells of a battery pack. The battery pack includes at least a first and second battery cell connected in parallel, with a thickness of an active layer and/or current collector of a battery cell having an altered thickness to reduce an impedance of the battery cell.
    Type: Application
    Filed: January 10, 2020
    Publication date: December 24, 2020
    Inventors: Loren L. Roy, Qingzhi GUO, Premanand RAMADASS, Hyungook YOON, Jinjun SHI
  • Publication number: 20200313223
    Abstract: The disclosed technology relates to balanced battery packs having battery cells of different capacities with higher capacity battery cells having a reduced impedance compared to lower capacity battery cells in the battery pack. The battery pack includes at least a first and second battery cell connected in parallel, with the second battery cell having a higher capacity than a capacity of the first battery cell. Tabs extending from electrodes of the second battery cell are disposed near a center of the electrodes to reduce an impedance of the second battery cell.
    Type: Application
    Filed: January 10, 2020
    Publication date: October 1, 2020
    Inventors: Loren L. Roy, Qingzhi GUO, Premanand RAMADASS, Hyungook YOON, Jinjun SHI
  • Publication number: 20200261551
    Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
    Type: Application
    Filed: February 3, 2020
    Publication date: August 20, 2020
    Inventors: Jinjun Shi, Mohammad Ariful Islam, Yingjie Xu, Omid C. Farokhzad, Bruce Zetter
  • Publication number: 20200206145
    Abstract: This invention relates to amphiphile-polymer particles, compositions, methods of making, and methods of use thereof.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Inventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
  • Publication number: 20200185704
    Abstract: Disclosed herein is a composite particulate comprising a plurality of active material particles; and a single graphene sheet or a plurality of graphene sheets surrounds the plurality of active material particles and a surface of the composite particulate, wherein a single graphene sheet or a plurality of graphene sheets provides an electron-conducting path.
    Type: Application
    Filed: January 8, 2020
    Publication date: June 11, 2020
    Inventors: Aruna Zhamu, Jinjun Shi, Guorong Chen, Qing Fang, Bor Z. Jang
  • Publication number: 20200085758
    Abstract: Nanoparticulate pharmaceutical formulations and methods for co-delivery of two or more species of nucleic acids for simultaneous suppression and expression of target genes in a cell, are provided. The nanoparticles encapsulate two or more nucleic acid species. The first nucleic acid suppresses expression of a gene or product thereof, e.g., inhibitory nucleic acid, such as antisense, siRNA, miRNA, Dicer siRNA, piRNA, etc. The second nucleic acid increases expression of, or encodes, an endogenous or exogenous protein or polypeptide, e.g., an mRNA. The first and second nucleic acid species simultaneously target or affect the same or different cellular processes within a cell including communication, senescence, DNA repair, gene expression, metabolism, necrosis, and apoptosis.
    Type: Application
    Filed: December 18, 2017
    Publication date: March 19, 2020
    Inventors: Omid Farokhzad, Xiaoding Xu, Jinjun Shi
  • Patent number: 10583091
    Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 10, 2020
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
  • Publication number: 20200061162
    Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
    Type: Application
    Filed: November 9, 2017
    Publication date: February 27, 2020
    Inventors: Jinjun Shi, Mohammad Ariful Islam, Yingjie Xu, Omid C. Farokhzad, Bruce Zetter
  • Patent number: 10559811
    Abstract: A nano graphene-enhanced particulate for use as a lithium-ion battery anode active material, wherein the particulate is formed of a single sheet of graphene or a plurality of graphene sheets and a plurality of fine anode active material particles with a size smaller than 10 ?m. The graphene sheets and the particles are mutually bonded or agglomerated into the particulate with at least a graphene sheet embracing the anode active material particles. The amount of graphene is at least 0.01% by weight and the amount of the anode active material is at least 0.1% by weight, all based on the total weight of the particulate. A lithium-ion battery having an anode containing these graphene-enhanced particulates exhibits a stable charge and discharge cycling response, a high specific capacity per unit mass, a high first-cycle efficiency, a high capacity per electrode volume, and a long cycle life.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: February 11, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Aruna Zhamu, Jinjun Shi, Guorong Chen, Qing Fang, Bor Z. Jang
  • Publication number: 20190350870
    Abstract: This disclosure relates to particles, compositions, methods of making, and methods of use thereof.
    Type: Application
    Filed: February 3, 2017
    Publication date: November 21, 2019
    Inventors: Omid C. Farokhzad, Jun Wu, Xi Zhu, Jinjun Shi
  • Patent number: 10307487
    Abstract: Disclosed herein are microvessel endothelial cell surface markers and methods, compositions, agents, and kits relating to those surface markers.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: June 4, 2019
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital
    Inventors: Ulrich H. von Andrian, Aude Thiriot, Omid Farokhzad, Jinjun Shi
  • Publication number: 20190117799
    Abstract: Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.
    Type: Application
    Filed: April 3, 2017
    Publication date: April 25, 2019
    Inventors: Xiaoding Xu, Jinjun Shi, Omid C. Farokhzad
  • Patent number: 10206941
    Abstract: Disclosed herein are genes which are differentially expressed in venule endothelial cells (V-ECs) compared to non-venule endothelial cells (NV-ECs) and methods and compositions relating to those genes. Also disclosed herein are methods of modulating the venuleness of an endothelial cell or microvessel, methods of modulating leukocyte trafficking, methods of modulating inflammation, methods of targeting agents to tissues based on their ability to bind to surface markers expressed in a microvessel (e.g., venules and non-venules), methods of identifying the venuleness of endothelial cells or microvessels, methods of identifying agents that modulate the venuleness of endothelial cells or microvessels, methods of identifying agents that target microvessels, methods for treating diseases associated with leukocyte trafficking, methods for treating inflammatory diseases, and compositions and kits for use in the methods.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: February 19, 2019
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Ulrich H. von Andrian, Aude Thiriot, Omid Farokhzad, Jinjun Shi
  • Publication number: 20170304213
    Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.
    Type: Application
    Filed: October 23, 2015
    Publication date: October 26, 2017
    Inventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
  • Publication number: 20170200938
    Abstract: A nano graphene-enhanced particulate for use as a lithium-ion battery anode active material, wherein the particulate is formed of a single sheet of graphene or a plurality of graphene sheets and a plurality of fine anode active material particles with a size smaller than 10 ?m. The graphene sheets and the particles are mutually bonded or agglomerated into the particulate with at least a graphene sheet embracing the anode active material particles. The amount of graphene is at least 0.01% by weight and the amount of the anode active material is at least 0.1% by weight, all based on the total weight of the particulate. A lithium-ion battery having an anode containing these graphene-enhanced particulates exhibits a stable charge and discharge cycling response, a high specific capacity per unit mass, a high first-cycle efficiency, a high capacity per electrode volume, and a long cycle life.
    Type: Application
    Filed: January 11, 2017
    Publication date: July 13, 2017
    Inventors: Aruna Zhamu, Jinjun Shi, Guorong Chen, Qing Fang, Bor Z. Jang
  • Patent number: 9685678
    Abstract: A material suitable for use in an electrode, preferably an anode, and processes of its formation are provided. The material includes an electrode base material and an organic artificial solid electrolyte interface material including a water soluble organic polymer coating the electrode base material. The polymer is polymerized with a crosslinker to form the organic artificial solid electrolyte interface material. The resulting artificial SEI coated electrode material demonstrates superior discharge rate capacity and cycle stability.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: June 20, 2017
    Assignee: A123 Systems, LLC
    Inventors: Viet Vu, Jinjun Shi, Pu Zhang