Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Abstract: Provided are a binding protein targeting HER2, a preparation method and use thereof. The binding protein includes the following amino acid sequence (a): NDEMRX1TYW X2IALF X3 X4ML X5N X6X7KR X8 X9IR X10LYDDP X11X12A X13 X14LEX15 X16A X17LEA X18 X19 X20. The binding protein can bind to HER2 and has an excellent affinity with HER2. A radionuclide molecular imaging probe may be prepared by means of nuclide labeling, and it can be used in the molecular imaging diagnosis and improve the tumor imaging diagnosis to a molecular level of specific expression of tumor cells, and the HER2 expression in possible tumor lesions in vivo can be monitored in real time before a treatment scheme is determined or in the process of monitoring a medicament treatment progress.

Abstract: A collector assembly includes a first collector and a pipe. The first collector includes an outlet pipe. A pipe chamber of the outlet pipe is in communication with an inner chamber of the first collector. The pipe includes an inlet end portion and an outlet end portion. The inlet end portion is located in the first collector. The outlet end portion is at least partially located in the outlet pipe. An inner chamber of the pipe is in communication with the pipe chamber of the outlet pipe and the inner chamber of the first collector. At least part of the outlet end portion is located in the pipe chamber of the outlet pipe. A heat exchanger having the collector assembly is also disclosed.

Abstract: The present invention relates to the anti-SARS-CoV-2-infection protein and vaccine, and belongs to the field of medicine. Due to the lack of efficient drugs for SARS-CoV-2 infection prevention and treatment in the prior art, the present invention provides an anti-SARS-CoV-2-infection protein, which contains a domain that binds with the angiotensin-converting enzyme 2 (ACE2) receptor as contained in the SARS-CoV-2 S protein. One the other hand, the present invention also provides a vaccine for SARS-CoV-2 infection prevention and/or treatment, which comprises the anti-SARS-CoV-2-infection protein as well as the pharmaceutically acceptable excipient or auxiliary ingredient. The present invention mainly induces the production of antibodies in the body for immunoreaction and blocks the binding the SARS-CoV-2 S protein and the ACE2 receptor of the host cell, thus helping the host to fight against the corona virus infection.

Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Abstract: A screening method is provided. Cells secreting target antibodies are screened by mixing candidate cells labeled with a first fluorescent molecule, a capture antigen and a labeled antibody against a target antibody and incubating, labeling using a high content cell imager and sorting using flow cytometry so as to screen cells secreting target antibodies. The screening method disclosed in the present application can automatically complete the labeling and sorting of target candidate cells in high throughput by labeling with a fluorescent molecule in combination with high-content cell imager and flow cytometer, so as to provide sufficient quantity of cells for subsequent amplification to obtain their antibody sequences and screen affinity antibodies. This method greatly improves the screening efficiency.

Abstract: A screening method is provided. Cells secreting target antibodies are screened by mixing candidate cells labeled with a first fluorescent molecule, a capture antigen and a labeled antibody against a target antibody and incubating, labeling using a high content cell imager and sorting using flow cytometry so as to screen cells secreting target antibodies. The screening method disclosed in the present application can automatically complete the labeling and sorting of target candidate cells in high throughput by labeling with a fluorescent molecule in combination with high-content cell imager and flow cytometer, so as to provide sufficient quantity of cells for subsequent amplification to obtain their antibody sequences and screen affinity antibodies. This method greatly improves the screening efficiency.

Abstract: A method for displaying bullet screens can include: acquiring detection boxes by detecting human-body parts in a plurality of image frames in a target video; and determining a masked region of each of the image frames based on detection boxes in the each of the image frames and a ratio of the detection boxes in the each of the image frames in an image frame to which the detection boxes belong, wherein the client player does not display bullet screens in the masked region when playing the target video.

Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Abstract: A method for displaying bullet screens can include: acquiring detection boxes by detecting human-body parts in a plurality of image frames in a target video; and determining a masked region of each of the image frames based on detection boxes in the each of the image frames and a ratio of the detection boxes in the each of the image frames in an image frame to which the detection boxes belong, wherein the client player does not display bullet screens in the masked region when playing the target video.

Abstract: The present application discloses a magnetic microchip having a graph code as well as a preparation method and application thereof. The magnetic microchip comprises: a graph code comprising more than one opaque microstructure mainly consisting of colloid aggregates formed by aggregating magnetic solid particles, wherein adjacent magnetic solid particles are isolated at least by an organic molecule and/or an inorganic molecule; and a transparent encapsulating structure at least used for wrapping the opaque microstructure. The magnetic microchip of the present application is prepared by adopting a micromachining process and has high in machining precision and repeatability, the size difference between different batches or between different individuals at the same batch can be ignored, use is convenient, and accuracy of a detection result can be effectively ensured, thereby greatly improving analysis quality.

Abstract: The disclosure discloses an encoded chip based micro-array and a preparation method thereof. In a typical embodiment, the preparation method comprises: providing a carrier, which has at least one fluid accommodating cavity, wherein at least one carrying surface is distributed in the fluid accommodating cavity; uniformly coating the carrying surface with an adhesive; adding a selected fluid to the fluid accommodating cavity till the carrying surface is immersed by the selected fluid; depositing encoded microchips dispersed in the selected fluid on the carrying surface, and enabling the encoded microchips to be combined with the adhesive distributed on the carrying surface; and curing the adhesive, thereby fixing the microchips onto the carrying surface. The disclosure further discloses a biochemical kit based on the micro-array, a biochemical detection system and method, and the like.

Abstract: The present application discloses a magnetic microchip having a graph code as well as a preparation method and application thereof. The magnetic microchip comprises: a graph code comprising more than one opaque microstructure mainly consisting of colloid aggregates formed by aggregating magnetic solid particles, wherein adjacent magnetic solid particles are isolated at least by an organic molecule and/or an inorganic molecule; and a transparent encapsulating structure at least used for wrapping the opaque microstructure. The magnetic microchip of the present application is prepared by adopting a micromachining process and has high in machining precision and repeatability, the size difference between different batches or between different individuals at the same batch can be ignored, use is convenient, and accuracy of a detection result can be effectively ensured, thereby greatly improving analysis quality.

Abstract: A method for split screen display on an electronic device, includes: receiving an operation signal which triggers displaying a multi-task management interface; displaying the multi-task management interface, wherein the multi-task management interface displays thereon acquired applications running on the electronic device; when it is detected that a user selects a first application and at least one second application from the acquired applications, generating a split screen display interface based on the first application and the at least one second application; and displaying the split screen display interface, so that the first application and the at least one second application are running and displayed on the split screen display interface simultaneously.

Abstract: Methods for forming a gate structure of a circuit structure are provide. The methods for forming the gate structure may include: forming a first gate pattern in a gate mask layer, the forming including a first etching of rounded corner portions of the first gate pattern; forming a second gate pattern in the gate mask layer, the second gate pattern at least partially overlapping the first gate pattern, the forming including a second etching of rounded corner portions of the second gate pattern; and, etching the gate mask layer using the first gate pattern and second gate pattern to form the gate structure.

Abstract: A micro-liquid phase reaction method based on a substrate with a hydrophilic-hydrophobic patterned surface, including the following: applying a liquid phase system containing a hydrotropic substance and/or an amphipathic substance to a hydrophobic smooth plane in a sample-spotting manner to form an array of tiny droplets, subsequently removing the solvent in each droplet to bond the hydrotropic substance and/or amphipathic substance in each droplet to the hydrophobic smooth plane so as to form an array of hydrophilic bonding points, then moving an aqueous phase system or hydrophilic liquid phase system containing more than one reactants over the hydrophobic smooth plane, thereby forming island-like tiny reaction droplets at each hydrophilic bonding point, and finally under the set reaction conditions, reacting the reactants in each tiny reaction droplet.

Abstract: Methods for forming a gate structure of a circuit structure are provide. The methods for forming the gate structure may include: forming a first gate pattern in a gate mask layer, the forming including a first etching of rounded corner portions of the first gate pattern; forming a second gate pattern in the gate mask layer, the second gate pattern at least partially overlapping the first gate pattern, the forming including a second etching of rounded corner portions of the second gate pattern; and, etching the gate mask layer using the first gate pattern and second gate pattern to form the gate structure.

Abstract: Methods for forming a gate structure of a circuit structure are provide. The methods for forming the gate structure may include: forming a first gate pattern in a gate mask layer, the forming including a first etching of rounded corner portions of the first gate pattern; forming a second gate pattern in the gate mask layer, the second gate pattern at least partially overlapping the first gate pattern, the forming including a second etching of rounded corner portions of the second gate pattern; and, etching the gate mask layer using the first gate pattern and second gate pattern to form the gate structure.

Abstract: A method for fabricating an integrated circuit includes providing an semiconductor wafer includes forming in an upper mandrel layer a first upper mandrel having a first critical dimension and a second upper mandrel having a second critical dimension; forming upper sidewall spacers along sidewalls of the first upper mandrel while leaving the second upper mandrel without sidewall spacers; removing the first upper mandrel from between the upper sidewall spacers; transferring a pattern of the upper sidewall spacers and of the second upper mandrel into a lower mandrel layer to form first lower mandrels according to the pattern of the upper sidewall spacers and a second lower mandrel according to the pattern of the second upper mandrel; and forming lower sidewall spacers along sidewalls of the first and second lower mandrels.

Abstract: Methods for fabricating integrated circuits are provided. One method includes decomposing a master pattern layout for a semiconductor device layer that includes a target metal line with a target interconnecting via/contact into a first sub-pattern and a second sub-pattern. The target metal line is decomposed into a first line feature pattern that is part of the first sub-pattern and a second line feature pattern that is part of the second sub-pattern such that the first and second line feature patterns have overlapping portions defining a stitch that corresponds to the target interconnecting via/contact. A first photomask is generated that corresponds to the first sub-pattern. A second photomask is generated that corresponds to the second sub-pattern.