Patents by Inventor Jixiang Liu

Jixiang Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Violet laser excitable dyes and their method of use
    Patent number: 9644099
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: May 9, 2017
    Assignee: Life Technologies Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen Yue, Jolene Ann Bradford
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20170037248
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 9, 2017
    Inventors: Robert Batchelor, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG, Kyle GEE
  • VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE
    Publication number: 20160355682
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Application
    Filed: June 13, 2016
    Publication date: December 8, 2016
    Inventors: Gayle BULLER, Jixiang Liu, Stephen Yue, Jolene Ann Bradford
  • Pyrenyloxysulfonic acid fluorescent agents
    Patent number: 9513284
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 6, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • 7-hydroxycoumarin-based cell-tracking reagents
    Patent number: 9400273
    Abstract: Described herein are compounds, methods, and kits for long-term tracking of cell proliferation, differentiation, and/or function. The compounds of the present invention are novel cell-tracking reagents, efficiently excitable with a 405-nm violet laser, that provide bright fluorescence intensity, uniform cell staining, and good retention within cells as well as low toxicity toward cells.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 26, 2016
    Assignee: Life Technologies Corporation
    Inventors: Jixiang Liu, Hee Chol Kang, Kyle Gee, Christopher Langsdorf, Jolene Bradford, Gayle Buller
  • Carbofluorescein lactone ion indicators and their applications
    Patent number: 9346778
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 24, 2016
    Assignee: AAT Bioquest, Inc.
    Inventors: Zhenjun Diwu, Haitao Guo, Ruogu Peng, Qin Zhao, Jixiang Liu, Jinfang Liao
  • Carbofluorescein Lactone Ion Indicators and Their Applications
    Publication number: 20160108015
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 21, 2016
    Inventors: Zhenjun Diwu, Haitao Guo, Ruogu Peng, Qin Zhao, Jixiang Liu, Jinfang Liao
  • Carbofluorescein lactone ion indicators and their applications
    Patent number: 9279817
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: March 8, 2016
    Assignee: AAT Bioquest, Inc.
    Inventors: Zhenjun Diwu, Haitao Guo, Ruogu Peng, Qin Zhao, Jixiang Liu, Jinfang Liao
  • Fluorinated resorufin compounds and their application
    Patent number: 9212385
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: December 15, 2015
    Assignee: Life Technologies Corporation
    Inventors: Robert H. Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS
    Publication number: 20150247863
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Application
    Filed: May 12, 2015
    Publication date: September 3, 2015
    Inventors: Zhenjun DIWU, Jixiang LIU, Kyle GEE
  • VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE
    Publication number: 20150050685
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Application
    Filed: July 28, 2014
    Publication date: February 19, 2015
    Inventors: Gayle BULLER, Jixiang LIU, Stephen YUE, Jolene BRADFORD
  • Carbofluorescein Lactone Ion Indicators and Their Applications
    Publication number: 20140378344
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.
    Type: Application
    Filed: August 4, 2014
    Publication date: December 25, 2014
    Inventors: Zhenjun Diwu, Haitao Guo, Ruogu Peng, Qin Zhao, Jixiang Liu, Jinfang Liao
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings
    Publication number: 20140356873
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 4, 2014
    Inventors: Zhenjun DIWU, Jixiang LIU, Kyle GEE
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
    Patent number: 8846925
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: September 30, 2014
    Assignee: Life Technologies Corporation
    Inventors: Zhenjun Diwu, Jixiang Liu, Kyle Gee
  • Violet laser excitable dyes and their method of use
    Patent number: 8822695
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: September 2, 2014
    Assignee: Life Technologies Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen Yue, Jolene Bradford
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20140220612
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG, Kyle GEE
  • PYRENYLOXYSULFONIC ACID FLUORESCENT AGENTS
    Publication number: 20140193926
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Application
    Filed: November 14, 2013
    Publication date: July 10, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Richard HAUGLAND, Wai-Yee Leung, Jixiang Liu
  • Modified actinomycin-based nucleic acid stains and methods of their use
    Patent number: 8653261
    Abstract: Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure: wherein R is H or NH2; R1, R2, R3, and R4 are independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; R3 and/or R4 comprise a quaternary nitrogen atom; and R5 is H, F, or Cl.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: February 18, 2014
    Assignee: Life Technologies Corporation
    Inventors: Stephen Yue, Jixiang Liu, Jolene Bradford
  • Pyrenyloxysulfonic acid fluorescent agents
    Patent number: 8614294
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: December 24, 2013
    Assignee: Life Technologies Corporation
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20130102014
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Harley Batchelor, Yue Ge, Iain D. Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg