Patents by Inventor Jixiang Liu

Jixiang Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Violet laser excitable dyes and their method of use
    Patent number: 8415477
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: April 9, 2013
    Assignee: Life Technologies Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen Yue, Jolene Bradford
  • PYRENYLOXYSULFONIC ACID FLUORESCENT AGENTS
    Publication number: 20130079497
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Application
    Filed: August 23, 2012
    Publication date: March 28, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings
    Publication number: 20120315661
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Application
    Filed: May 14, 2012
    Publication date: December 13, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Zhenjun DIWU, Jixiang LIU, Kyle GEE
  • Pyrenyloxysulfonic acid fluorescent agents
    Patent number: 8268886
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: September 18, 2012
    Assignee: Life Technologies Corporation
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
    Patent number: 8183375
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: May 22, 2012
    Assignee: Life Technologies Corporation
    Inventors: Zhenjun Diwu, Jixiang Liu, Kyle Gee
  • Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
    Patent number: 8173698
    Abstract: The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 8, 2012
    Assignee: Life Technologies Corporation
    Inventors: Iain Johnson, Jixiang Liu, Brian Patch, Wai-Yee Leung
  • Violet laser excitable dyes and their method of use
    Patent number: 8158801
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: April 17, 2012
    Assignee: Life Technologies Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen T. Yue, Jolene Bradford
  • PYRENYLOXYSULFONIC ACID FLUORESCENT AGENTS
    Publication number: 20120045848
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Application
    Filed: May 31, 2011
    Publication date: February 23, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Richard Haugland, Wai-Yee Leung, Jixiang Liu
  • VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE
    Publication number: 20120004397
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Application
    Filed: May 31, 2011
    Publication date: January 5, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Gayle Buller, Jixiang Liu, Stephen T. Yue, Jolene Bradford
  • Pyrenyloxysulfonic acid fluorescent agents
    Patent number: 8039642
    Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: October 18, 2011
    Assignee: Life Technologies Corporation
    Inventors: Jixiang Liu, Richard Haugland, Wai-Yee Leung
  • MODIFIED ACTINOMYCIN-BASED NUCLEIC ACID STAINS AND METHODS OF THEIR USE
    Publication number: 20110236887
    Abstract: Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.
    Type: Application
    Filed: October 26, 2009
    Publication date: September 29, 2011
    Applicant: Life Techologies Corporation
    Inventors: Stephen Yue, Jixiang Liu, Jolene Bradford
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20110086341
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 14, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings
    Publication number: 20110027800
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Application
    Filed: October 11, 2010
    Publication date: February 3, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Zhenjun DIWU, Jixiang Liu, Kyle Gee
  • Fluorinated resorufin compounds and their application
    Patent number: 7875261
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: January 25, 2011
    Assignee: Life Technologies Corporation
    Inventors: Robert Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
    Patent number: 7816519
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 19, 2010
    Assignee: Life Technologies Corporation
    Inventors: Zhenjun Diwu, Jixiang Liu, Kyle Gee
  • Fluorinated resorufin compounds and their application
    Patent number: 7432372
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: October 7, 2008
    Assignee: Invitrogen Corporation
    Inventors: Robert Hardy Batchelor, Yue Ge, Iain D. Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Aaron Emrys Smalley, Thomas Harry Steinberg
  • Environmental Sensitive Fluorogenic Compounds and Their Application for Singlet Oxygen and Protein Detection
    Publication number: 20080160627
    Abstract: The present invention provides fluorogenic probes and corresponding fluorescent compounds, methods of using the probes, compounds and kits that include the probes.
    Type: Application
    Filed: February 29, 2008
    Publication date: July 3, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Iain JOHNSON, Wai-Yee Leung, Jixiang Liu, Brian Richard Patch
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20080113341
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: January 16, 2008
    Publication date: May 15, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG
  • DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS
    Publication number: 20070093652
    Abstract: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
    Type: Application
    Filed: November 16, 2006
    Publication date: April 26, 2007
    Applicant: INVITROGEN CORPORATION
    Inventors: Zhenjun Diwu, Jixiang Liu, Kyle Gee
  • VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE
    Publication number: 20070077549
    Abstract: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.
    Type: Application
    Filed: September 26, 2006
    Publication date: April 5, 2007
    Applicant: Invitrogen Corporation
    Inventors: Gayle Buller, Jixiang Liu, Stephen Yue, Jolene Bradford