Patents by Inventor Joan D. Tyner

Joan D. Tyner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant antibodies against hepatitis C virus and methods of obtaining and using same
    Patent number: 7858752
    Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: December 28, 2010
    Assignee: Abbott Laboratories
    Inventors: Bailin Tu, Joan D. Tyner, James W. Scheffel, Michael K. White, Jeffrey M. Werneke, Robert N. Ziemann, David J. Hawksworth, Mary S. Pinkus, Robin A. Gutierrez
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20100227775
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: May 21, 2010
    Publication date: September 9, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann
  • ANTIBODIES TO TROPONIN I AND METHODS OF USE THEREOF
    Publication number: 20100216720
    Abstract: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
    Type: Application
    Filed: February 24, 2009
    Publication date: August 26, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Bailin Tu, Joan D. Tyner, Dagang Huang, Robert N. Ziemann, Lowell J. Tyner
  • Human ring specific BNP antibodies
    Patent number: 7731965
    Abstract: The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: June 8, 2010
    Inventors: Jessie W. Shih, Joan D. Tyner, Matthew S. Matias, Mary S. Pinkus, Susan E. Brophy, David J. Dagfal, David J. Hawksworth, Bryan C. Tieman
  • NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) PROTEIN ISOFORMS ENRICHED FROM URINE AND RECOMBINANT CHINESE HAMSTER OVARY (CHO) CELLS AND RELATED COMPOSITIONS, ANTIBODIES, AND METHODS OF ENRICHMENT, ANALYSIS AND USE
    Publication number: 20100116662
    Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 13, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Salman Ali, Ryan M. Bonn, Frank C. Grenier, Tracey D. Rae, Kevin R. Rupprecht, Hina N. Syed, Bailin Tu, Joan D. Tyner, Ryan F. Workman
  • PIGF-1 ASSAY AND KITS AND COMPONENTS THEREOF
    Publication number: 20100015637
    Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
    Type: Application
    Filed: June 16, 2009
    Publication date: January 21, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Lianli Chi, Saul A. Datwyler, David J. Hawksworth, Don M. Laird, Sharmila Manoj, Mary S. Pinkus, Dominick L. Pucci, Carol S. Ramsay, David C. Sogin, Bailin Tu, Joan D. Tyner, Lowell J Tyner, Zhiguang Yu, Robert N. Ziemann
  • PIGF-1 Assay and kits and components thereof
    Publication number: 20100004306
    Abstract: The present disclosure relates to, among other things, methods for determining whether a subject receiving treatment with a drug has obtained an efficacious blood level of the drug. Moreover, the present disclosure also relates to methods of determining whether a subject predisposed to or suffering from a disease will benefit from treatment with a drug, and the response of a subject receiving treatment (e.g., such as for cancer) by monitoring biomarkers of angiogenesis. In particular, the disclosure relates to PlGF-1 companion diagnostic methods and products.
    Type: Application
    Filed: June 17, 2009
    Publication date: January 7, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Evelyn Mary McKeegan, Saul A. Datwyler, David J. Hawksworth, Don M. Laird, Dominick L. Pucci, David C. Sogin, Joan D. Tyner, Robert N. Ziemann, Peter James Ansell, Ke K. Zhang
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090269777
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 29, 2009
    Applicant: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Ryan F. Workman, Robert N. Ziemann
  • ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF
    Publication number: 20090263894
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 22, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann
  • Anti-T. Cruzi Antibodies and Methods of Use
    Publication number: 20090203037
    Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.
    Type: Application
    Filed: December 23, 2008
    Publication date: August 13, 2009
    Applicant: Abbott Laboratories
    Inventors: Susan E. Brophy, David J. Hawksworth, Dinesh O. Shah, Robert W. Siegel, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Lowell J. Tyner, Robert N. Ziemann
  • Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays
    Publication number: 20090203038
    Abstract: The present disclosure relates to isolated antibodies that do not bind to brain natriuretic peptide that can be used as a reagent to reduce heterophilic interference in an immunoassay.
    Type: Application
    Filed: December 23, 2008
    Publication date: August 13, 2009
    Applicant: Abbott Laboratories
    Inventors: Susan E. Brophy, William E. Brown, III, Walt J. Keirans, Joan D. Tyner
  • GLYCOSYLATED MAMMALIAN NGAL AND USE THEREOF
    Publication number: 20090176274
    Abstract: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.
    Type: Application
    Filed: December 8, 2008
    Publication date: July 9, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Bailin Tu, Joan D. Tyner
  • Antibodies and Improved Test Sample Handling Methods for Use in Assays for Myeloperoxidase
    Publication number: 20090148866
    Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.
    Type: Application
    Filed: May 16, 2008
    Publication date: June 11, 2009
    Applicant: Abbott Laboratories
    Inventors: Saul A. Datwyler, David J. Hawksworth, Stephen C. Hsu, Matthew S. Matias, David P. Pacenti, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman, Joan D. Tyner, Robert N. Ziemann, Lowell J. Tyner
  • IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL
    Publication number: 20090123946
    Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
    Type: Application
    Filed: December 5, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, Frank C. Grenier, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Ryan F. Workman, Robert N. Ziemann, Lowell J. Tyner
  • GLYCOSYLATED MAMMALIAN NGAL AND USE THEREOF
    Publication number: 20090123970
    Abstract: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.
    Type: Application
    Filed: December 5, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Bailin Tu, Joan D. Tyner
  • HUMAN BNP IMMUNOSPECIFIC ANTIBODIES
    Publication number: 20090123473
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Application
    Filed: August 11, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan E. Brophy, Joan D. Tyner, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman, Lowell J. Tyner
  • ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF
    Publication number: 20090124022
    Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
    Type: Application
    Filed: April 16, 2008
    Publication date: May 14, 2009
    Applicant: Abbott Laboratories
    Inventors: Larry G. Birkenmeyer, Suresh M. Desai, David J. Hawksworth, Edward T. Olejniczak, Qiaoqiao Ruan, Robert W. Siegel, Sergey Y. Tetin, Bryan C. Tieman, Bailin Tu, Joan D. Tyner, Robert N. Ziemann, Lowell J. Tyner
  • Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26)
    Patent number: 7531639
    Abstract: The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: May 12, 2009
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sheng C. Lou, Jeffrey C. Hunt, John G. Konrath, Xiaoxing Qiu, James W. Scheffel, Joan D. Tyner
  • Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26)
    Patent number: 7531641
    Abstract: The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: May 12, 2009
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sheng C. Lou, Jeffrey C. Hunt, John G. Konrath, Xiaoxing Qiu, James W. Scheffel, Joan D. Tyner
  • Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26).
    Patent number: 7531642
    Abstract: The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: May 12, 2009
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sheng C. Lou, Jeffrey C. Hunt, John G. Konrath, Xiaoxing Qiu, James W. Scheffel, Joan D. Tyner