Abstract: The devices and methods of placement of such devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce and maintain collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The medical kits disclosed herein are also directed to produce and maintain collateral openings through airway walls.

Abstract: For application to analog, mixed-signal, and custom digital circuits, a system and method to do: global statistical optimization (GSO), global statistical characterization (GSC), global statistical design (GSD), and block-specific design. GSO can perform global yield optimization on hundreds of variables, with no simplifying assumptions. GSC can capture and display mappings from design variables to performance, across the whole design space. GSC can handle hundreds of design variables in a reasonable time frame, e.g., in less than a day, for a reasonable number of simulations, e.g., less than 100,000. GSC can capture design variable interactions and other possible nonlinearities, explicitly capture uncertainties, and intuitively display them. GSD can support the user's exploration of design-to-performance mappings with fast feedback, thoroughly capturing design variable interactions in the whole space, and allow for more efficiently created, more optimal designs.

Abstract: For application to analog, mixed-signal, and custom digital circuits, a system and method to begin with a complex problem description that encompasses many variables from statistical manufacturing, the circuit's environment, and the circuit's design parameters, but then apply techniques to prune the scope of the problem to make it manageable for manual design and more efficient automated design, and finally use that pruned problem for more efficient and effective design.

Abstract: A system and method to analyze analog, mixed-signal, and custom digital circuits. The system and method displays to a user characteristic values of a circuit and statistical uncertainty values of the characteristic values early in a sampling or characterization run of the circuit. The characteristic values and their statistical uncertainties are updated as the sampling or characterization run progresses. The user can halt the sampling or characterization run once a desired level of uncertainty is attained. The system can automatically halt the sampling or characterization run, once the statistical uncertainty lie within a pre-determined range.

Abstract: A system and method of generating a set of circuit simulation data, applying data mining to for knowledge extraction from the data, and graphically presenting the extracted knowledge in a format that is easy to digest to a designer.

Abstract: For application to analog, mixed-signal, and custom digital circuits, a system and method to improve the flow of setting up a set of simulations, a characterization, or optimization problem via an interactive circuit schematic. A system and method to visualize circuit simulation data in which at least one of the views is an enhanced, interactive schematic view.

Abstract: The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

Abstract: The devices and methods of placement of such devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce and maintain collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. The medical kits disclosed herein are also directed to produce and maintain collateral openings through airway walls.

Abstract: A signal processing system includes a level dependent bass management system. The level dependent bass management system utilizes audio input signal level information to apply at least one of multiple, available bass management solutions to generate one or more output signals from the audio input signal. In at least one embodiment, initially the level dependent bass management system boosts components of the audio input signal in the low frequency range by an amount sufficient to at least partially compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system. If boosting alone cannot completely compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system, the level dependent bass management system processes the audio input signal using an alternate low frequency management solution.

Abstract: This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11 CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines.

Abstract: The present invention automatically corrects for subwoofer or other speaker crossover settings or other parameters by providing an adjustable factor passed upon not only pulse location, but on pulse width. In FIG. 2, as the low-pass frequency of the subwoofer is decreased, either by the crossover setting or the physical design of the subwoofer, the impulse response is shifted to the right and the width of the impulse increases. By relating the adjustment factor to the width of the impulse, the accuracy of the computed distance is greatly increased. The relation may be found doing a simple polynomial curve fitting to empirical data from several subwoofers at various crossover settings and distances, storing that data, and then measuring pulse location and width of the actual subwoofer during the setup routine, and adjusting the distance (delay) calculations accordingly.

Abstract: The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.

Abstract: The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.

Abstract: Devices and methods for altering gaseous flow within a lung to improve the expiration cycle of an individual, particularly individuals having chronic obstructive pulmonary disease. The methods and devices create channels in lung tissue and maintain the patency of these surgically created channels in tissue. Maintaining the patency of the channels allows air to pass directly out of the lung tissue which facilitates the exchange of oxygen ultimately into the blood and/or decompresses hyper-inflated lungs.

Abstract: The methods and devices disclosed altering gaseous flow within a lung to improve the expiration cycle of individuals having Chronic Obstructive Pulmonary Disease.

Abstract: A cathodic protection monitoring system for buried metal objects comprising a transponder hard-wire connected to a sacrificial anode and a reference electrode, each of the transponder, the sacrificial anode and the reference electrode being buried underground in close proximity to the buried metal object to be protected, thereby forming a first principal circuit between the sacrificial anode and the buried metal object and forming a second principal circuit between the reference electrode and the buried metal object. The system further comprises a portable transceiver disposed above ground tuned to a frequency of the transponder. Power for operation of the transponder is drawn from the cathodic protection circuit, thereby obviating the need for connections to above ground power supplies.

Abstract: An apparatus and method for providing reinforced surgical fastener suture lines to prevent tissue tearing and fluid leakage following the creation of an anastomosis, the closing of margins following the removal of diseased tissue, and/or the ligating and dividing of individual blood vessels. A retainer assembly is provided having an alignment frame and a pressure equalization member. The alignment frame includes an internally disposed receiving area for housing the pressure equalization member and a pair of guide channels disposed in fluid communication with the receiving area for guiding the jaw members of a surgical fastener applying device into contact with pledget material disposed within the receiving area.

Abstract: A prosthetic article for surgical implantation within the body of a host in a surgical stapling procedure comprises a strip of host-tissue-compatible animal tissue material that is initially removably affixed between the spaced-apart legs a U-shaped buttress member to create a tubular configuration that can readily slip over the jaws of a conventional surgical stapler. When the staple gun is fired, the staples penetrate through the strips of animal tissue and the host tissue and thus serve to reinforce the staple line. Because the buttress member is releasibly attached to the strip of animal tissue, the buttress member can be readily separated and discarded following the firing of a staple gun.

Abstract: To reinforce a line of surgical staples in host tissue, a strip of xenogeneic or autogenic tissue, such as cross-linked pericardium or dura mater harvested from horses, cows, pigs, sheep and humans, is appropriately adhered to the apposed surfaces of a staple cartridge supporting jaw and an anvil jaw of a surgical staple gun so that when tissue to be excised is positioned between the jaws and the staple gun is fired, the staples will penetrate the two layers of animal tissue and the intervening host tissue. Actuation of the cutting blade on the stapler or the use of a separate cutting instrument severs the tissue and the two layers of animal tissue along the staple line. When used in performing a lung reduction procedure, the animal tissue reinforcing strips create an air-tight seal about the staples preventing air leaks.

Abstract: A prosthetic article for surgical implantation within the body of a host in a surgical stapling procedure comprises a strip of host-tissue-compatible animal tissue material that is initially removably affixed between the spaced-apart legs a U-shaped buttress member to create a tubular configuration that can readily slip over the jaws of a conventional surgical stapler. When the staple gun is fired, the staples penetrate through the strips of animal tissue and the host tissue and thus serve to reinforce the staple line. Because the buttress member is releasibly attached to the strip of animal tissue, the buttress member can be readily separated and discarded following the firing of a staple gun.