Abstract: Systems and methods provide for implementation of a messaging protocol that provides security necessary for clinical messaging while also providing scalability needed to properly function within a clinical setting. The messaging protocol provides for federation of messages across messaging domains with a direct target address or via a role or group endpoint address that resolves to one or more target addresses. The messaging protocol also provides the ability to include content other than text in messages.

Abstract: A device for movably mounting a storage container in relation to the storage bed of a pickup truck. The device includes a container support frame with a mounting member configured to be fixedly secured in relation to the pickup truck storage bed, and a lift arm having a first end coupled to the container support frame for pivotal movement about a first pivot axis and a second end configured to be coupled to the storage container for pivotal movement about a second pivot axis. The second end of the lift arm is movable along an arcuate path about the first pivot axis between a stowed position in which the storage container is disposed between the side rails and an extended position in which the storage container is disposed above a side rail. The storage container is pivotable about the second pivot axis to maintain an upright orientation in the stowed and extended positions, providing a variety of convenient access and storage options.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: An exercise device with a pair of upper links coupled to the frame and a pair of lower links pivotally coupled to the upper links is provided. A pair of pedals is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each upper link and a second end opposite to the first end. A first and a second pivot arm, each pivotally coupled to the frame, may be included, each pivot arm receiving a respective pushrod. A pliable connector may be coupled to the first pivot arm and the second pivot arm, thus providing compliant reciprocating movement of the upper links.

Abstract: An exercise device with a pair of upper links coupled to a frame and a pair of lower links pivotally and respectively coupled to the upper links is provided. A pedal is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each respective upper link and a second end opposite to the first end. A first and a second damper arm, each pivotally coupled to the frame, may be included, each damper arm receiving a respective pushrod. An actuator may be coupled to the first damper arm and the second damper arm, thus providing movement of the first and second pushrods to alter a resting position of the first and second upper leg links with respect to the frame.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: An exercise device with a pair of upper links coupled to the frame and a pair of lower links pivotally coupled to the upper links is provided. A pair of pedals is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each upper link and a second end opposite to the first end. A first and a second pivot arm, each pivotally coupled to the frame, may be included, each pivot arm receiving a respective pushrod. A pliable connector may be coupled to the first pivot arm and the second pivot arm, thus providing compliant reciprocating movement of the upper links.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: An exercise device with a pair of upper links coupled to the frame and a pair of lower links pivotally coupled to the upper links is provided. A pair of pedals is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each upper link and a second end opposite to the first end. A first and a second pivot arm, each pivotally coupled to the frame, may be included, each pivot arm receiving a respective pushrod. A pliable connector may be coupled to the first pivot arm and the second pivot arm, thus providing compliant reciprocating movement of the upper links.

Abstract: A device for movably mounting a storage container in relation to the storage bed of a pickup truck. The device includes a container support frame with a mounting member configured to be fixedly secured in relation to the pickup truck storage bed, and a lift arm having a first end coupled to the container support frame for pivotal movement about a first pivot axis and a second end configured to be coupled to the storage container for pivotal movement about a second pivot axis. The second end of the lift arm is movable along an arcuate path about the first pivot axis between a stowed position in which the storage container is disposed between the side rails and an extended position in which the storage container is disposed above a side rail. The storage container is pivotable about the second pivot axis to maintain an upright orientation in the stowed and extended positions, providing a variety of convenient access and storage options.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: A device for movably mounting a storage container in relation to the storage bed of a pickup truck. The device includes a container support frame with a mounting member configured to be fixedly secured in relation to the pickup truck storage bed, and a lift arm having a first end coupled to the container support frame for pivotal movement about a first pivot axis and a second end configured to be coupled to the storage container for pivotal movement about a second pivot axis. The second end of the lift arm is movable along an arcuate path about the first pivot axis between a stowed position in which the storage container is disposed between the side rails and an extended position in which the storage container is disposed above a side rail. The storage container is pivotable about the second pivot axis to maintain an upright orientation in the stowed and extended positions, providing a variety of convenient access and storage options.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: An exercise device with a pair of upper links coupled to the frame and a pair of lower links pivotally coupled to the upper links is provided. A pair of pedals is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each upper link and a second end opposite to the first end. A first and a second pivot arm, each pivotally coupled to the frame, may be included, each pivot arm receiving a respective pushrod. A pliable connector may be coupled to the first pivot arm and the second pivot arm, thus providing compliant reciprocating movement of the upper links.

Abstract: A device for movably mounting a storage container in relation to the storage bed of a pickup truck. The device includes a container support frame with a mounting member configured to be fixedly secured in relation to the pickup truck storage bed, and a lift arm having a first end coupled to the container support frame for pivotal movement about a first pivot axis and a second end configured to be coupled to the storage container for pivotal movement about a second pivot axis. The second end of the lift arm is movable along an arcuate path about the first pivot axis between a stowed position in which the storage container is disposed between the side rails and an extended position in which the storage container is disposed above a side rail. The storage container is pivotable about the second pivot axis to maintain an upright orientation in the stowed and extended positions, providing a variety of convenient access and storage options.

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g.

Abstract: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g.