Abstract: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions.

Abstract: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions.

Abstract: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract: The present invention relates to compositions containing signal transduction modulator compounds, to methods for treating or preventing inflammation, or promoting healthy joints, using the compounds and to kits for the same.

Abstract: A dished head header assembly for a heat exchanger having a containment body that includes a rounded, or dished, wall portion forming an interior cavity. A flange attaches to the containment body and fastens the header assembly to the heat exchanger. A plurality of refrigerant passageways are extended through an opening in the containment body into the interior cavity. At least one baffle is attached to the rounded wall portion. The baffle divides the interior cavity into a plurality of sub-cavities. At least one divider divides the sub-cavities into a plurality of chambers. The plurality of passageways includes an inlet connection and an outlet connection for a plurality of refrigerant circuits. Each passageway is disposed in a corresponding chamber of the plurality of chambers. Extensions into the headers with diffusers insure efficient operation and performance of the heat exchanger. The adjustable flow restrictor plate maintains optimum velocities to further enhance performance.

Abstract: A height adjuster for a vehicle safety restraint has a web guide (38) and a track (84) for the web guide. The web guide (38) is vertically moveable along the track (84). A lock (76) has a lock condition for preventing vertical movement of the web guide (38) along the track (84) and an unlocked condition for allowing vertical movement of the web guide (38) along the track (84). A release mechanism (50, 80) is operatively connectable to said lock (76). The release mechanism (50, 80) has a release position for placing the lock (76) in the unlocked condition and an unreleased position from maintaining the lock (76) in the lock condition. A lift mechanism (66) at least partially assists vertical movement of the web guide (38) along the track (84) and biases the release mechanism (50, 80) toward the unreleased position.

Abstract: An exercise device upon which a user generally standing upright supported by foot platforms suspended from a frame via linkages in which the linkage lengths and pivot points correspond generally to the users upper and lower legs and hip and knee joints. This device not only allows natural free and spontaneous leg movement, able to simulate such exercises as walking, jogging, running, stepping, skiing or gliding, bicycling, climbing, reverse action and various isolated leg exercises, where the exercises can be performed at random generally without the need to reconfigure the device. This device preferably includes an isolation system capable of simulating natural forces throughout the entire range of movement in the horizontal and/or vertical plane. A safety/suspension system can be provided, alone or in combination with the isolation system, to resist sudden foot movement in the same direction, yet allows a slow and controlled tilting of the linkages whereby the user may simulate uphill and downhill travel.

Abstract: A dished head header assembly for a heat exchanger having a containment body that includes a rounded, or dished, wall portion forming an interior cavity. A flange attaches to the containment body and fastens the header assembly to the heat exchanger. A plurality of refrigerant passageways are extended through an opening in the containment body into the interior cavity. At least one baffle is attached to the rounded wall portion. The baffle divides the interior cavity into a plurality of sub-cavities. At least one divider divides the sub-cavities into a plurality of chambers. The plurality of passageways includes an inlet connection and an outlet connection for a plurality of refrigerant circuits. Each passageway is disposed in a corresponding chamber of the plurality of chambers. Extensions into the headers with diffusers insure efficient operation and performance of the heat exchanger. The adjustable flow restrictor plate maintains optimum velocities to further enhance performance.

Abstract: A height adjuster for a vehicle safety restraint has a web guide (38) and a track (84) for the web guide. The web guide (38) is vertically moveable along the track (84). A lock (76) has a lock condition for preventing vertical movement of the web guide (38) along the track (84) and an unlocked condition for allowing vertical movement of the web guide (38) along the track (84). A release mechanism (50, 80) is operatively connectable to said lock (76). The release mechanism (50, 80) has a release position for placing the lock (76) in the unlocked condition and an unreleased position from maintaining the lock (76) in the lock condition. A lift mechanism (66) at least partially assists vertical movement of the web guide (38) along the track (84) and biases the release mechanism (50, 80) toward the unreleased position.

Abstract: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions

Abstract: A method is disclosed for processing seismic data from concurrently recorded co-located pressure sensors and geophones. The seismic data are processed by first determining an upgoing wavefield and a downgoing wavefield in the seismic data. Adaptive subtraction is then applied to at least one of the upgoing wavefield and the downgoing wavefield to remove the noise from the signal. In alternative embodiments, the upgoing wavefield can be used as a noise model for the downgoing wavefield or the downgoing wavefield can be used as a noise model for the upgoing wavefield.

Abstract: A method is disclosed for processing seismic data from concurrently recorded co-located pressure sensors and geophones. The seismic data are processed by first determining an upgoing wavefield and a downgoing wavefield in the seismic data. Adaptive subtraction is then applied to at least one of the upgoing wavefield and the downgoing wavefield to remove the noise from the signal. In alternative embodiments, the upgoing wavefield can be used as a noise model for the downgoing wavefield or the downgoing wavefield can be used as a noise model for the upgoing wavefield.