Patents by Inventor Joel Moss

Joel Moss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factors that bind intestinal toxins
    Publication number: 20060051440
    Abstract: Methods for neutralizing bacterial toxins such as Shiga toxins and cholera toxins are disclosed. In a particular embodiment, a method is provided for treating a subject suffering from an infection caused by an Stx-producing organism by administering a therapeutically effective amount of a hop bract tannin obtained from Humulus lupulus. Also provided are methods for isolating polyphenolic compounds that bind Stx molecules, and methods for detecting the presence of Stx molecules in a biological sample. In a disclosed embodiment, a subject infected with a Shiga toxin-producing E. coli strain is treated by enterically administering a high molecular weight fraction of hop bract extract to the subject.
    Type: Application
    Filed: January 31, 2003
    Publication date: March 9, 2006
    Inventors: Joel Moss, Masatoshi Noda
  • Modified defensins and their use
    Publication number: 20060036083
    Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
    Type: Application
    Filed: February 18, 2003
    Publication date: February 16, 2006
    Inventors: Joel Moss, Rodney Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
  • Mammalian muscle NAD: arginine ADP-ribosyltransferase
    Patent number: 5834310
    Abstract: This invention relates to the identification and molecular characterization of NAD:arginine ADP-ribosyltransferases. Sequences from the rabbit skeletal muscle NAD:arginine ADP-ribosyltransferase and the human NAD:arginine ADP-ribosyltransferase are provided herein. Recombinant protein is expressed from a recombinant gene vector containing at least 15 continuous bases of genes encoding these sequences.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: November 10, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joel Moss, Ian Okazaki, Anna Zolkiewska, Maria S. Nightingale
  • Clones encoding mammalian ADP-ribosylarginine hydrolases
    Patent number: 5716816
    Abstract: The present invention relates to the production of mammalian ADP-ribosylarginine hydrolases. These enzymes can be manufactured using recombinant DNA technology and are useful in regulation of proteins involved in key metabolic pathways.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: February 10, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joel Moss, Sally J. Stanley, Maria S. Nightingale, Lucia Monaco, James J. Murtagh, Jr., Tatsuyuki Takada
  • Mammalian guanine nucleotide binding protein with an ADP-ribosylation factor domain
    Patent number: 5514600
    Abstract: The invention provides a method for detecting the presence of ARD 1 protein in a sample. The method includes the steps of providing labeled or immobilized anti-ARD 1 antibody in a reaction zone, introducing sample into the reaction zone such that ARD 1 protein in the sample, if present, will react with said antibody to form an immunological complex, and detecting the formation of said immunological complex. Cells, nucleotide and amino acid sequences and vectors associated with ARD 1 are also described.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: May 7, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joel Moss, Koichi Mishima, Maria S. Nightingale, Mikako Tsuchiya
  • Mammalian guanine nucleotide binding protein with an ADP-rybosylation factor domain
    Patent number: 5386021
    Abstract: The invention provides a method for detecting the presence of ARD 1 protein in a sample. The method includes the steps of providing labeled or immobilized anti-ARD 1 antibody in a reaction zone, introducing sample into the reaction zone such that ARD 1 protein in the sample, if present, will react with said antibody to form an immunological complex, and detecting the formation of said immunological complex. Cells, nucleotide and amino acid sequences and vectors associated with ARD 1 are also described.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: January 31, 1995
    Assignee: The United States of America, as represented by the Department of Health & Human Services
    Inventors: Joel Moss, Koichi Mishima, Maria S. Nightingale, Mikako Tsuchiya