Abstract: Medical devices for sympathetic nerve modulation are disclosed. An example medical device for sympathetic nerve modulation may include a catheter shaft having a distal region. An expandable member may be coupled to the distal region. A flexible circuit assembly may be attached to the expandable member. The flexible circuit assembly may include a first electrode strip, a second electrode strip, and a sensor strip disposed between the first electrode strip and the second electrode strip. The first electrode strip may include a first electrode. The second electrode strip may include a second electrode. The first electrode and the second electrode may define a pair of bipolar electrodes.

Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. An expandable frame may be disposed over the balloon. The expandable frame may include a plurality of struts extending from a proximal end region to a distal end region. One or more cutting members may be secured to the expandable frame.

Abstract: Fluid delivery devices, systems, and methods disclosed herein may include a cannula that may include a shaft comprising a proximal end, a distal end, and a lumen. A plurality of radial apertures may be disposed along a delivery portion of the shaft. Each radial aperture may be in fluid communication with the lumen. At least one echogenic marker may be disposed along the shaft within or adjacent to the delivery portion. A body may be disposed within the distal end of the shaft.

Abstract: A percutaneous circulatory support system includes a percutaneous circulatory support device including an impeller disposed within an impeller housing, the impeller being rotatable relative to the impeller housing to cause blood flow through the impeller housing. The system further includes a cannula coupled to the impeller housing, a cannula delivery tool configured for receiving and radially compressing the cannula, the cannula delivery tool having a proximal portion positioned adjacent a tapered portion, and a distal portion positioned adjacent the tapered portion.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

Abstract: A transport and delivery system which may be used for injectable materials such as radioactive injectables. The system includes a base configured to hold a material transport device containing the injectable material, and a cover including a material delivery system and a material access device. The cover is configured to be mated over the base to result in alignment of the material access device with the material transport device to allow the material delivery system to deliver the injectable materials from within the material transport device to a patient. A priming cap may be provided to facilitate priming of the material delivery system and material access device to be substantially airless.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

Abstract: An atherectomy system may include an atherectomy apparatus including a drive housing, a catheter shaft extending distally from the drive housing, and a rotatable drive shaft extending within the catheter shaft and operably coupled to the drive housing, the rotatable drive shaft having a guidewire lumen configured to receive a guidewire; and a guidewire management device including: a frame including at least one frame rail extending longitudinally; a movable tray slidably coupled to the at least one frame rail; and a guidewire locking element fixed to the frame. The drive housing may be releasably secured to the movable tray.

Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. An expandable frame may be disposed over the balloon. The expandable frame may include a plurality of struts extending from a proximal end region to a distal end region. One or more cutting members may be secured to the expandable frame.

Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. An expandable frame may be disposed over the balloon. The expandable frame may include a plurality of struts extending from a proximal end region to a distal end region. One or more cutting members may be secured to the expandable frame.

Abstract: A filtering sheath includes an elongated tubular member defined by a circumferential wall and having a distal end, a proximal end, and a lumen extending therebetween. The distal end has a plurality of slits extending through the circumferential wall, the plurality of slits defining an expandable filter region. The plurality of slits are arranged in a pattern that allows the expandable filter region to move between a first, contracted configuration, and a second, expanded configuration.

Abstract: An implant for occluding a flow through a vessel may comprise a body member having a first end portion, a second end portion, and an intermediate rod portion extending between the first end portion and the second end portion and a mesh having base layer and a plurality of micro-pillars extending from a first surface of the base layer. The mesh may be disposed about at least a portion of the body such that the micro-pillars extending generally radially outward from the body member. The plurality of micro-pillars may be configured to extend into an adjacent tissue.

Abstract: An example closure device is disclosed. The closure device includes a framework including a first end region, a second end region and a medial region extending therebetween. The medical device also includes a biodegradable tissue ingrowth member extending over at least a portion of the framework, wherein the tissue ingrowth member is configured to promote tissue ingrowth thereupon, and wherein the tissue ingrowth is configured to seal an opening in the heart.

Abstract: A device includes a hollow needle with a lumen extending therethrough. The needle is sized and shaped to extend through an endoscopic shaft to a target tissue within a living body. The needle has a distal end with a sharpened distal tip for puncturing the target tissue and removing a portion of the tissue in the lumen. The device further includes a cylindrical stylet having a shaft sized and shaped to extend through the lumen of the needle and a distal end with a pointed distal tip for puncturing the target tissue. When the stylet is extended, the pointed distal tip of the stylet extends distally a predetermined distance past the sharpened distal tip of the needle.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

Abstract: The present disclosure, in its various aspects, is directed generally to medical devices, and more specifically to catheter accessory devices and related systems and methods. In an embodiment, an instrument accessory device may include a body with an instrument lumen through which an instrument may extend through. An expandable member may be disposed about the distal end of the body. An elongate delivery member may be attached to the body and in communication with the expandable member at a distal end of the delivery member. The delivery member may be configured to slide the instrument lumen of the body and the expandable member along the length of the instrument when extended therethrough. Other embodiments are addressed within.

Abstract: A locking element for securing an expandable anchor member in a shortened configuration may include a plurality of engagement features configured to releasably secure the locking element to a first end portion of the expandable anchor member without using any external elements, wherein the locking element is configured to engage a post member secured to a second end portion of the expandable anchor member opposite the first end portion in the shortened configuration.

Abstract: Medical devices for sympathetic nerve modulation are disclosed. An example medical device for sympathetic nerve modulation may include a catheter shaft having a distal region. An expandable member may be coupled to the distal region. A flexible circuit assembly may be attached to the expandable member. The flexible circuit assembly may include a first electrode strip, a second electrode strip, and a sensor strip disposed between the first electrode strip and the second electrode strip. The first electrode strip may include a first electrode. The second electrode strip may include a second electrode. The first electrode and the second electrode may define a pair of bipolar electrodes.