Abstract: Medical devices for sympathetic nerve modulation are disclosed. An example medical device for sympathetic nerve modulation may include a catheter shaft having a distal region. An expandable member may be coupled to the distal region. A flexible circuit assembly may be attached to the expandable member. The flexible circuit assembly may include a first electrode strip, a second electrode strip, and a sensor strip disposed between the first electrode strip and the second electrode strip. The first electrode strip may include a first electrode. The second electrode strip may include a second electrode. The first electrode and the second electrode may define a pair of bipolar electrodes.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable balloon may be coupled to the catheter shaft. The balloon may be capable of shifting between a folded configuration and an expanded configuration. A support structure may be coupled to the balloon. The support structure may be capable of shifting the balloon toward the folded configuration. A plurality of elongate flexible electrode assemblies may be disposed on the balloon. The elongate flexible electrode assemblies may be oriented at an angle relative to a longitudinal axis of the balloon.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: An atherectomy system may include an atherectomy apparatus including a drive housing, a catheter shaft extending distally from the drive housing, and a rotatable drive shaft extending within the catheter shaft and operably coupled to the drive housing, the rotatable drive shaft having a guidewire lumen configured to receive a guidewire; and a guidewire management device including: a frame including at least one frame rail extending longitudinally; a movable tray slidably coupled to the at least one frame rail; and a guidewire locking element fixed to the frame. The drive housing may be releasably secured to the movable tray.

Abstract: A filtering sheath includes an elongated tubular member defined by a circumferential wall and having a distal end, a proximal end, and a lumen extending therebetween. The distal end has a plurality of slits extending through the circumferential wall, the plurality of slits defining an expandable filter region. The plurality of slits are arranged in a pattern that allows the expandable filter region to move between a first, contracted configuration, and a second, expanded configuration.

Abstract: A cutting balloon catheter including a balloon mounted on a distal portion of a catheter shaft. An expandable frame may be disposed over the balloon. The expandable frame may include a plurality of struts extending from a proximal end region to a distal end region. One or more cutting members may be secured to the expandable frame.

Abstract: An implant for occluding a flow through a vessel may comprise a body member having a first end portion, a second end portion, and an intermediate rod portion extending between the first end portion and the second end portion and a mesh having base layer and a plurality of micro-pillars extending from a first surface of the base layer. The mesh may be disposed about at least a portion of the body such that the micro-pillars extending generally radially outward from the body member. The plurality of micro-pillars may be configured to extend into an adjacent tissue.

Abstract: The present disclosure provides occlusion devices which comprise (a) a self-expanding support frame having a longitudinal axis comprising a plurality of loops each having an orifice, the support frame being self-expandable from a constrained shape to an unconstrained shape, and (b) a covering material covering an orifice of at least one of the loops. Also provided are assemblies and kits that contain such occlusion devices, and methods of delivering such occlusion devices to a patient.

Abstract: An example closure device is disclosed. The closure device includes a framework including a first end region, a second end region and a medial region extending therebetween. The medical device also includes a biodegradable tissue ingrowth member extending over at least a portion of the framework, wherein the tissue ingrowth member is configured to promote tissue ingrowth thereupon, and wherein the tissue ingrowth is configured to seal an opening in the heart.

Abstract: An intravascular catheter is disclosed that includes an elongated shaft defined by a wall including at least one port extending through the wall into a lumen. At least one channel may be defined between layers of polymer making up the catheter shaft. The channel extends along at least a portion of the shaft and is in fluid communication with the port. Outer and inner diameters of the catheter may be substantially constant along the length of the catheter.

Abstract: A sensor device for sensing endoluminal geometry may include an expandable element disposed on the distal region of a shaft. The expandable element may be configured to move a collapsed configuration and an expanded configuration. The expandable element may include one or more sensor elements configured to sense proximity of the sensor element to tissue. The sensor device may include an indicator configured to distinguish between contact of the sensor element with tissue, loss of contact and proximity of the sensor element to tissue.

Abstract: A renal nerve ablation device may include an elongate tubular member having a distal region. An expandable member may be coupled to the distal region. An electrode support may be coupled to the distal region of the elongate tubular member and extend over a body of the expandable member. The electrode support may be free of connection to the body of the expandable member. One or more electrodes may be coupled to the electrode support.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: An example medical device is disclosed. The device includes a tubular member having a lumen defined therein and a distal end portion, the distal end portion defining a guidewire port. The medical device also includes an expandable frame disposed along the distal end portion of the tubular member, the expandable frame being designed to shift between a first configuration and an expanded configuration. The frame includes a base, an end region and a plurality of struts extending between the base and the end region, the struts defining a plurality of apertures along the frame. The medical device also includes a cover attached to a portion of the frame and the cover is configured to cover one or more of the plurality of apertures such that the frame will align the guidewire port with an opening in a heart valve when the frame is positioned within a body lumen.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

Abstract: The present disclosure provides occlusion devices which comprise (a) a self-expanding support frame having a longitudinal axis comprising a plurality of loops each having an orifice, the support frame being self-expandable from a constrained shape to an unconstrained shape, and (b) a covering material covering an orifice of at least one of the loops. Also provided are assemblies and kits that contain such occlusion devices, and methods of delivering such occlusion devices to a patient.

Abstract: A method of making a spacer cage is disclosed. The method may include providing a tube having an outer diameter, a first second, a second section and a middle section having a first end connected to the first section and a second end connected to the second section, cutting the middle section to form strut elements of the spacer cage and cutting a plurality of longitudinal slits in the first and second sections to allow radial expansion of the first and second sections, expanding the tube using a mandrel, heat setting the tube while on the mandrel, and subsequent the heat setting, removing the first and second sections from the tube.

Abstract: A delivery catheter includes a soft, atraumatic distal tip. The distal tip is configured to transition from a folded configuration to an unfolded configuration during delivery of a medical device. A wall thickness of the distal tip may be increased such that the distal tip is biased to remain in the unfolded configuration after delivery. Additionally, the increased wall thickness in a selected region of the distal tip may cause the distal tip to resist and/or prevent collapse of the distal tip during retrieval and/or repositioning of the medical device when the medical device comes into contact with a distal end of the catheter. The distal edge of the distal tip may be rounded so as to prevent the distal tip from damaging tissue during advancement of the catheter to a target location within a patient's body.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may be a deflectable medical device that includes a catheter shaft having a distal end. An ablation electrode may be disposed at the distal end. A deflection mechanism may be coupled to the catheter shaft. The deflection mechanism may include a deflection body and a pull wire coupled to the deflection body. The deflection body may have a longitudinally-extending furrow formed therein. A flex member may be disposed adjacent to the deflection mechanism.