Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: A system and methods for generating dynamic market pricing that is fair for both publishers and advertisers and the use of the pricing in real-time auctions. When a user views content over the internet, an online publisher provides content to the user with executable instructions, which notify an advertisement source that there is an impression for filling by an advertiser. The impression is submitted to a real-time bidding market for competing advertisers to bid to fill the impression with an advertisement. The system and methods generate dynamic pricing for the individual competing advertisers and use the dynamic pricing to compare advertiser bids to determine a highest or winning bid and a clearing price associated with the highest or winning bid.

Abstract: The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same.

Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same.

Abstract: Systems and methods for efficiently obtaining a summary from and locating data in a log file allow a user to efficiently obtain summary information and locate specific data records even in large log files. The system includes a configuration program, a log writing program, and a log reading program. The configuration program allows the user to control the duration of monitoring and the frequency of summary record creation by the log writing program. The log writing program writes data records, summary records, and summary information to a log file in response to monitored events. The log reading program retrieves summary records and data records from the log file using summary information in response to user requests.

Abstract: A computer controlled coffee steeping machine which extracts a minimum of undesirable acids and a maximum of desirable flavorings by steeping the grinds at a low temperature for a long time. The computer is programmed to maintain the lowest water temperature possible for producing a full flavored coffee within a time period selected by the user. At the end of the steeping period, the computer triggers the release of a spring propelled filter basket which lifts the grinds out of the liquid. Finally the coffee is automatically heated to drinking temperature.

Abstract: An apparatus for forming a fibrous structure includes a rotatable main drum having projections on its outer periphery for separating fibers from a fibrous feed, and directing the separated fibers through a fiber working section. The working section includes a movable satellite member positioned close to the main drum and having projections on its outer periphery for cooperating with the projections on the main drum to individualize the fibers as they are directed through the working section. A baffle is positioned adjacent the satellite member; between the satellite member and the exit from the working section. The baffle includes a lower air-directing section positioned close to the outer periphery of the main drum and having an air-diverting surface for intercepting air conveyed to it by the outer periphery of the main drum as the main drum is rotated.

Abstract: A method for forming a fibrous structure from a fibrous feed by: (1) directing the feed into engagement with projections on a rotating fiberizing drum for separating fibers from the feed; (2) directing the separated fibers to a release zone at which they are released from the periphery of the drum for subsequent conveyance to a foraminous forming surface upon which the fibrous structure is formed; and (3) sealing the outer periphery of the drum in a region between the fiber release zone and the region in which the fibrous feed is directed into engagement with the fiberizing drum by directing a gas against the outer periphery of the drum with a force component in a direction opposed to the direction of rotation of the drum and at a static pressure of at least about two atmospheres to provide a gas velocity which is sufficiently high to remove air trapped between the projections of the drum as the drum is being rotated.

Abstract: The invention resides in a method of forming a nonwoven web by employing a forming apparatus which includes a fiberizing roll for separating fibers from a feed mat and entraining them in a gaseous medium, a foraminous forming surface through which the gaseous medium passes and upon which the fibers are condensed to form a fibrous web, and a formation duct between the fiberizing roll and the forming surface for defining a flow path for the gaseous suspension of fibers from the fiberizing roll to the forming surface; the improvement wherein the formation duct includes front and back, substantially planar inner surfaces which may slightly converge in a direction from the fiberizing roll to the forming surface, but preferably diverge at an angle of up to about 41/2 degrees when the forming surface is a curved surface of a cylindrical drum, and up to about 11/2 degrees when the forming surface is a linear surface of a forming belt; the formation duct being inclined to the forming surface to define an incidence ang