Patents by Inventor Joel R. Walker

Joel R. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THIENOPYRROLE COMPOUNDS AND USES THEREOF
    Publication number: 20200063110
    Abstract: Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds, and methods of using the thienopyrrole compounds.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 27, 2020
    Inventors: Sarah Duellman, Matthew B. Robers, Joel R. Walker, Wenhui Zhou, Chad Zimprich
  • COELENTERAZINE ANALOGUES
    Publication number: 20190389869
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: August 20, 2019
    Publication date: December 26, 2019
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker
  • Thienopyrrole compounds and uses thereof
    Patent number: 10513694
    Abstract: Thienopyrrole compounds that may inhibit Oplophorus-derived luciferases are disclosed, as well as compositions and kits comprising the thienopyrrole compounds, and methods of using the thienopyrrole compounds.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: December 24, 2019
    Assignee: PROMEGA CORPORATION
    Inventors: Sarah Duellman, Matthew B. Robers, Joel R. Walker, Wenhui Zhou, Chad Zimprich
  • INHIBITORS OF OPLOPHORUS LUCIFERASE-DERIVED BIOLUMINESCENT COMPLEXES
    Publication number: 20190382365
    Abstract: Compounds that may selectively inhibit Oplophorus luciferase-derived bioluminescent complexes, e.g., NanoBiT® bioluminescent complex, are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 19, 2019
    Inventors: Joel R. Walker, Mary Hall, Christopher Todd Eggers, Horacio Lazaro
  • Coelenterazine analogues
    Patent number: 10428075
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: October 1, 2019
    Assignee: PROMEGA CORPORATION
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker
  • HETEROARYL INHIBITORS OF PDE4
    Publication number: 20190270759
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: April 26, 2019
    Publication date: September 5, 2019
    Inventors: Mark E. GURNEY, Timothy J. HAGEN, Xuesheng MO, A. Samuel VELLEKOOP, Donna L. ROMERO, Robert CAMPBELL, Joel R. WALKER, Lei ZHU
  • Heteroaryl inhibitors of PDE4
    Patent number: 10364258
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: July 30, 2019
    Assignee: Tetra Discovery Partners, LLC
    Inventors: Mark E. Gurney, Timothy J. Hagen, Xuesheng Mo, A. Samuel Vellekoop, Donna L. Romero, Robert F. Campbell, Joel R. Walker, Lei Zhu
  • Dual protected pro-coelenterazine substrates
    Patent number: 10316070
    Abstract: Described are coelenterazine analogs, methods for making the analogs, kits comprising the analogs, and methods of using the compounds for the detection of luminescence in luciferase-based assays with low backgrounds and enhanced signal-to-background ratios.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: June 11, 2019
    Assignee: Promega Corporation
    Inventors: Wenhui Zhou, Joel R. Walker, Poncho Meisenheimer
  • Substituted imidazo[1,2-A]pyrazines tethered to energy acceptors
    Patent number: 10280447
    Abstract: Described are substituted imidazo[1,2-a]pyrazine compounds of formula (I), which are coelenterazine analogs, methods for making the compounds, kits comprising the compounds, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: May 7, 2019
    Assignee: Promega Corporation
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker, Keith V. Wood, Wenhui Zhou
  • HETEROARYL INHIBITORS OF PDE4
    Publication number: 20190055269
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: August 24, 2018
    Publication date: February 21, 2019
    Inventors: Mark E. GURNEY, Timothy J. HAGEN, Xuesheng MO, A. Samuel VELLEKOOP, Donna L. ROMERO, Robert F. CAMPBELL, Joel R. WALKER, Lei ZHU
  • COELENTERAZINE ANALOGUES
    Publication number: 20180334463
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: May 17, 2018
    Publication date: November 22, 2018
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker
  • Heteroaryl inhibitors of PDE4
    Patent number: 10093686
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: October 9, 2018
    Assignee: Tetra Discovery Partners, LLC
    Inventors: Mark E. Gurney, Timothy J. Hagen, Xuesheng Mo, A. Samuel Vellekoop, Donna L. Romero, Robert F. Campbell, Joel R. Walker, Lei Zhu
  • FUNCTIONALIZED NANOLUC INHIBITORS
    Publication number: 20180222916
    Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.
    Type: Application
    Filed: December 28, 2017
    Publication date: August 9, 2018
    Inventors: Roderick G. Flemming, Mary Hall, Thomas Machleidt, Poncho Meisenheimer, Nidhi Nath, Matthew B. Robers, Joel R. Walker, Wenhui Zhou
  • Coelenterazine analogues
    Patent number: 10000500
    Abstract: Described are coelenterazine analogs, methods for making the analogs, kits comprising the analogs, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: June 19, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker
  • CELL IMPERMEABLE COELENTERAZINE ANALOGUES
    Publication number: 20180155350
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Inventors: Mary Hall, Thomas Kirkland, Poncho Meisenheimer, Rachel Friedman Ohana, Anton Shakhmin, Joel R. Walker, Wenhui Zhou
  • COELENTERAZINE ANALOGUES TETHERED TO ENERGY ACCEPTORS
    Publication number: 20180119200
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: November 1, 2017
    Publication date: May 3, 2018
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker, Keith V. Wood, Wenhui Zhou
  • DUAL PROTECTED PRO-COELENTERAZINE SUBSTRATES
    Publication number: 20180072781
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Inventors: Poncho Meisenheimer, Joel R. Walker, Wenhui Zhou
  • COELENTERAZINE ANALOGUES
    Publication number: 20180030059
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: July 27, 2017
    Publication date: February 1, 2018
    Inventors: Mary Hall, Thomas Kirkland, Thomas Machleidt, Anton Shakhmin, Joel R. Walker
  • HETEROARYL INHIBITORS OF PDE4
    Publication number: 20170342094
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: August 18, 2017
    Publication date: November 30, 2017
    Inventors: Mark E. GURNEY, Timothy J. HAGEN, Xuesheng MO, A. Samuel VELLEKOOP, Donna L. ROMERO, Robert F. CAMPBELL, Joel R. WALKER, Lei ZHU
  • Heteroaryl inhibitors of PDE4
    Patent number: 9777024
    Abstract: The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: October 3, 2017
    Assignee: Tetra Discovery Partners, LLC
    Inventors: Mark E. Gurney, Timothy J. Hagen, Xuesheng Mo, A. Samuel Vellekoop, Donna L. Romero, Robert F. Campbell, Joel R. Walker, Lei Zhu