Abstract: The invention includes a method and array for replicating and analyzing one or a plurality of different target sequences in nucleic acid samples. The different reactions for replicating the target sequences occur simultaneously on an array with selectively heatable array elements with their reaction surfaces, some of which have been modified differently, and in the sample solution disposed thereabove. The target sequences are analyzed using molecular detection on reaction surfaces of said array that have been modified with probe strands. The target strands are replicated and analyzed simultaneously, successively, or alternately.

Abstract: In a U-cup based seal of a rod, the basic body of the U-cup 3 is recessed relative to a square cross-sectional shape in the region of a radially inner outer edge 18 on the low pressure side in order to obtain a space 17 between the U-cup 3 and the opening, i.e. the passage opening 16 of a sealing gap 15, leading into a rectangular groove 4 guiding the U-cup 3. This space 17 remains at least partially also upon pressurization such that the U-cup 3 complete remains in the groove 4 upon pressurization and is not extruded into the sealing gap 15. This considerably reduces wear of the U-cup 3. An inner surface 24 of the U-cup shows liquid dragging bore reliefs formed as recesses 25 in the inner surface 24 of the U-cup 3 for transferring hydraulic liquid, disposed on a surface of the translatory movable machine part 1, from a low-pressure side N of the U-cup to a high-pressure side H of the U-cup 3 upon translatory movement of the movable machine part 1.

Abstract: The invention relates to an imaging method for simultaneously determining in vivo distributions of bioluminescent and/or fluorescent markers and radioactive markers at identical projection angles, the distribution of the bioluminescent and/or fluorescent markers being determined by separate detection of photons having a first average energy, which are emitted by the bioluminescent and/or fluorescent markers, by means of at least one first detector and the distribution of the radioactive markers being determined by simultaneous separate detection of photons having a second average energy, which are emitted by the radioactive markers, by means of at least one second detector. Furthermore, it also relates to an apparatus for carrying out the imaging method, containing at least one micro lens array optical tomographic imaging system as first detector, at least one single photon emission computer tomography (SPECT) detector as second detector.

Abstract: The invention relates to a dual-modality imaging system and a method for dual-modality imaging of an imaged object, wherein a magnetic resonance imaging (MRI) apparatus for acquiring MRI data and at least one optical imaging detector for acquiring optical imaging data are arranged to acquire the MRI data and the optical imaging data of the imaged object (10) simultaneously, the at least one optical imaging detector being a non-contact optical imaging detector.

Abstract: In a U-cup based seal of a rod, the basic body of the U-cup 3 is recessed relative to a square cross-sectional shape in the region of a radially inner outer edge 18 on the low pressure side in order to obtain a space 17 between the U-cup 3 and the opening, i.e. the passage opening 16 of a sealing gap 15, leading into a rectangular groove 4 guiding the U-cup 3. This space 17 remains at least partially also upon pressurization such that the U-cup 3 complete remains in the groove 4 upon pressurization and is not extruded into the sealing gap 15. This considerably reduces wear of the U-cup 3. An inner surface 24 of the U-cup shows liquid dragging bore reliefs formed as recesses 25 in the inner surface 24 of the U-cup 3 for transferring hydraulic liquid, disposed on a surface of the translatory movable machine part 1, from a low-pressure side N of the U-cup to a high-pressure side H of the U-cup 3 upon translatory movement of the movable machine part 1.

Abstract: The invention relates to an imaging method for simultaneously determining in vivo distributions of bioluminescent and/or fluorescent markers and radioactive markers at identical projection angles, the distribution of the bioluminescent and/or fluorescent markers being determined by separate detection of photons having a first average energy, which are emitted by the bioluminescent and/or fluorescent markers, by means of at least one first detector and the distribution of the radioactive markers being determined by simultaneous separate detection of photons having a second average energy, which are emitted by the radioactive markers, by means of at least one second detector. Furthermore, it also relates to an apparatus for carrying out the imaging method, containing at least one micro lens array optical tomographic imaging system as first detector, at least one single photon emission computer tomography (SPECT) detector as second detector.

Abstract: The invention relates to a dual-modality imaging system and a method for dual-modality imaging of an imaged object, wherein a magnetic resonance imaging (MRI) apparatus for acquiring MRI data and at least one optical imaging detector for acquiring optical imaging data are arranged to acquire the MRI data and the optical imaging data of the imaged object (10) simultaneously, the at least one optical imaging detector being a non-contact optical imaging detector.

Abstract: A compact and mobile gantry for 3-dimensional Application Specific Emission and/or Transmission Tomography (ASETT) imaging of the breast in single photon or coincidence emission modes, and single photon, or coincidence, or x-ray transmission modes. While the ASETT gantry was designed, built and evaluated for imaging metabolically active lesions in the pendant breast, it can also be used to image other organs and objects. This system overcomes physical constraints associated with imaging a pendulous breast in prone patients, while simultaneously satisfying sampling criteria for sufficient data collection in the pendulous breast reference frame. When combined with an offset cone-beam tomographic x-ray transmission imaging system, this dual modality ASETT system could provide simultaneous and coregistered structural and functional information about large or dense breasts, breasts with indeterminate x-ray mammography, and could also be used to accurately 3-dimensionally guide biopsy or surgical resection.

Abstract: The invention includes a method and array for replicating and analyzing one or a plurality of different target sequences in nucleic acid samples. The different reactions for replicating the target sequences occur simultaneously on an array with selectively heatable array elements with their reaction surfaces, some of which have been modified differently, and in the sample solution disposed thereabove. The target sequences are analyzed using molecular detection on reaction surfaces of said array that have been modified with probe strands. The target strands are replicated and analyzed simultaneously, successively, or alternately.

Abstract: A compact and mobile gantry for 3-dimensional Application Specific Emission and/or Transmission Tomography (ASETT) imaging of the breast in single photon or coincidence emission modes, and single photon, or coincidence, or x-ray transmission modes. While the ASETT gantry was designed, built and evaluated for imaging metabolically active lesions in the pendant breast, it can also be used to image other organs and objects. This system overcomes physical constraints associated with imaging a pendulous breast in prone patients, while simultaneously satisfying sampling criteria for sufficient data collection in the pendulous breast reference frame. When combined with an offset cone-beam tomographic x-ray transmission imaging system, this dual modality ASETT system could provide simultaneous and coregistered structural and functional information about large or dense breasts, breasts with indeterminate x-ray mammography, and could also be used to accurately 3-dimensionally guide biopsy or surgical resection.