Patents by Inventor Joerg Rosenberg

Joerg Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5641516
    Abstract: Compositions which contain active substances and are in the form of solid particles can be obtained by intimately mixing the active substance with a water-soluble melt composed ofa) 10-90% by weight of a water-soluble polymer A with a viscosity V.sub.a of 1,000-120,000 cps andb) 10-90% by weight of a water-soluble polymer B with a viscosity V.sub.b of 1-500 cpsas carrier substance, where the viscosities V.sub.a and V.sub.b are those of a 2% by weight aqueous solution at 20.degree. C., measured by the ASTM D 2363-72 capillary method (European Pharmacopoeia, Vol. III, p. 37), and processing the melt with shaping to give the particles.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: June 24, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Sven Grabowski, Axel Sanner, Joerg Rosenberg
  • Patent number: 5626864
    Abstract: A process with whose aid active substances of low solubility can be processed together with phospholipids to give a homogeneous solution, which comprisesa) mixing the active substance with a phospholipid,b) adding an acidic aqueous solution of a carbohydrate to the residue at elevated temperature, and stirring this mixture at elevated temperature until a homogeneous colloidal solution is produced, andc) cooling the solution, and adjusting to a pH of 4-5 and sterilizing is described.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: May 6, 1997
    Assignee: Knoll Aktiengesellscahft
    Inventors: Joerg Rosenberg, Cynthia Romerdahl, Juergen Heberger
  • Patent number: 5432196
    Abstract: A process for preparing an aqueous active substance solution which can be sterilized by filtration entails mixing anipamil hydrochloride with a phospholipid in the ratio of from 1:2 to 2:1 by weight, converting the resulting mixture into a gel by adding water at elevated temperature, and subsequently adding water to the gel at elevated temperature until the active substance is present in the required concentration.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: July 11, 1995
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Rolf Neidhardt, Guenter Blaich
  • Patent number: 5370877
    Abstract: .alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: December 6, 1994
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Hans-Heinrich Gruenhagen, Dieter Lenke
  • Patent number: 5354561
    Abstract: A process is described for the production of solid forms of active substances, which forms have good redispersibility in aqueous systems, which comprises mixing PEG and dextran with water and--if phase separation occurs--removing the upper phase, dissolving an active substance in the mixture, where appropriate adding a physiologically tolerated amphiphile, and subsequently removing the water.
    Type: Grant
    Filed: August 19, 1992
    Date of Patent: October 11, 1994
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Juergen Heberger
  • Patent number: 4958046
    Abstract: Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,x is 2 or 3,y is 12, 14, 16, 18 or 20, anda and b differ from one another and are 0 or 1,as well as the stereoisomers thereof and the preparation thereof are described. The compounds are suitable as active substances for antiarrhythmics.
    Type: Grant
    Filed: September 19, 1989
    Date of Patent: September 18, 1990
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Juergen Heberger, Hans-Heinrich Gruenhagen, Egon Brode, Gerda von Philipsborn