Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Methods, apparatus, and systems for efficient partitioning and construction of graphs for scalable high-performance search applications. A method for partitioning a set of ternary keys having one or more wildcards includes analyzing patterns of the set of ternary keys and storing ternary keys with the same pattern in the same subset. The patterns may include uncompressed patterns and compressed patterns. When there are more patterns than a target number of subgraphs, patterns are repeatedly merged until the number of merged patterns matches the target number of subgraphs. Table entries having ternary keys corresponding to the ternary keys in a final set of merged patterns of ternary keys are generated and partitioned into sub-tables, with each sub-table associated with a respective sub-graph. Tables with hundreds of thousands or millions of entries are supported.

Abstract: A multi-linkage vehicle door hinge and door hinge system for use in passenger vehicle entry/exit doors. The door hinge includes a first four bar linkage connected to a second four bar linkage. The door hinge operates to move a vehicle door panel between a closed position and an open position along a path of travel in a movement envelope that is parallel to the exterior surface of the vehicle. In one aspect, the door hinge provides twice as much lift as is required to package the door hinge in the vehicle. In another aspect, the door panel further rotates toward the vehicle centerline for applications having low vertical clearance. In another aspect, the door hinge includes a six-bar linkage.

Abstract: A variable valve actuation mechanism is provided for an internal combustion engine including at least one valve for control of gas admission to a cylinder of the engine and/or gas exhaust from the cylinder. The mechanism includes two concentrically arranged camshafts, a cam set comprising two cams, each fixed to a respective of the camshafts, whereby the camshafts are arranged to be turned in relation to each other, so as to change the combined profile of the cams, and a cam follower adapted to follow the combined profile of the cams and to actuate at least one of the at least one valve in dependence on the combined profile of the cams, wherein the cam follower includes two rollers, each roller being adapted to follow a respective one of the cams.

Abstract: A multi-linkage vehicle door hinge and door hinge system for use in passenger vehicle entry/exit doors. The door hinge includes a first four bar linkage connected to a second four bar linkage. The door hinge operates to move a vehicle door panel between a closed position and an open position along a path of travel in a movement envelope that is parallel to the exterior surface of the vehicle. In one aspect, the door hinge provides twice as much lift as is required to package the door hinge in the vehicle. In another aspect, the door panel further rotates toward the vehicle centerline for applications having low vertical clearance. In another aspect, the door hinge includes a six-bar linkage.

Abstract: A variable valve actuation mechanism is provided for an internal combustion engine including at least one valve for control of gas admission to a cylinder of the engine and/or gas exhaust from the cylinder. The mechanism includes two concentrically arranged camshafts, a cam set comprising two cams, each fixed to a respective of the camshafts, whereby the camshafts are arranged to be turned in relation to each other, so as to change the combined profile of the cams, and a cam follower adapted to follow the combined profile of the cams and to actuate at least one of the at least one valve in dependence on the combined profile of the cams, wherein the cam follower includes two rollers, each roller being adapted to follow a respective one of the cams.

Abstract: A method and a system for estimation of a soot load in a particle filter in an exhaust cleaning system, which estimation involves using a pressure drop across said particle filter in order to determine the soot load. Measurement of the pressure drop across the particle filter and therefore the estimation have to take place at a time when an exhaust mass flow of the exhaust cleaning system exceeds a flow threshold value, the particle filter is substantially free from water and a temperature of the particle filter exceeds a first threshold value. The result is a robust estimate of the soot load in the particle filter.

Abstract: A method for regeneration of a particle filter (202) pertaining to a combustion process, which filter treats exhaust gases arising from combustion in a combustion engine (101): During regeneration, controlling the engine (101) according to a first mode and a second mode, in the first mode, the engine (101) is controlled such that a high exhaust temperature is generated, determining a temperature of the particle filter (202), and controlling the engine (101) according to the first mode when the temperature determined is below a first value until the temperature reaches a higher second value, and then controlling the engine in the second mode. The invention relates also to a system and a vehicle (100).

Abstract: A method pertaining to regeneration of a particle filter (202) pertaining to a combustion process, which filter is arranged to treat exhaust gases arising from combustion in a combustion engine (101). When at least one measure for raising the temperature of the particle filter (202) is activated, determining a temperature for the particle filter (202), comparing the temperature determined with a first temperature and discontinuing the measure for raising the temperature of the particle filter (202) when the temperature determined is below the first temperature.

Abstract: An exhaust gas after treatment system includes a diesel particulate filter unit arranged downstream of a diesel engine, a NO2 reduction catalyst arranged downstream of said diesel particulate filter, a selective catalytic reduction (SCR) arrangement arranged downstream of said NO2 reduction catalyst, a first injector for feeding reducing agent into the exhaust gas arranged downstream said particulate filter and upstream said NO2 reduction catalyst, a second injector for feeding reducing agent into the exhaust gas arranged downstream said NO2 reduction catalyst and upstream said selective catalytic reduction (SCR) arrangement. An exhaust gas after treatment method is also provided.

Abstract: A system and an on-board-diagnosis method is provided for an exhaust aftertreatment system of an engine including a diesel particulate filter unit which encompasses a particulate filter in which soot can be oxidized by NO2 and constituents of the exhaust gas are deoxidized in a nitrogen-oxides reduction unit arranged downstream of the diesel particulate filter unit, wherein the exhaust gas flows from the diesel particulate filter unit to the nitrogen-oxides reduction unit. The on-board-diagnosis method includes estimating an NO2 content upstream of the nitrogen-oxides reduction unit, measuring at least one of an NOx or NO2 content upstream of the nitrogen-oxides reduction unit, performing a comparison between the estimated and the measured contents, and, based on the result of the comparison deciding on at least one conditioning step of the diesel particulate filter unit.

Abstract: A diesel engine system and a method for operating said system are provided. The diesel engine system includes a diesel engine provided with an exhaust conduit including a controllable supercharger located upstream of a catalytic converter, a fuel injector located between the supercharger and the catalytic converter, a diesel particulate filter located downstream of the catalytic converter, and a control unit for controlling the engine system. The control unit is arranged to determine that a regeneration of the particulate filter is required, which regeneration is initiated when a predetermined condition is fulfilled. The fuel injector is arranged to inject a predetermined amount of fuel during a first stage of the regeneration, and the supercharger is arranged to vary the flow rate of exhaust during the injection of fuel. The catalytic converter is arranged to combust the injected fuel, and the combusted fuel is arranged to burn particulates trapped within the diesel particulate filter.

Abstract: A system and a method are provided for operating an exhaust aftertreatment system of an engine in which one or more constituents of the exhaust gas are oxidized in an oxidation catalyst and one or more constituents of the exhaust gas are deoxidized by means of a group of possible chemical reactions of different type between the one or more constituents of the exhaust gas and catalytic material arranged in a selective-catalytic-reduction catalyst, wherein the exhaust gas flows from the oxidation catalyst to the selective-catalytic-reduction catalyst, wherein the steps are performed: (a) adjusting at least one desired ratio among one or more pairs of the one or more constituents by varying a space velocity of the exhaust gas in at least the oxidation catalyst; (b) varying the space velocity of the exhaust gas by varying one or more operation parameters of the engine; and (c) establishing the ratio to a value at least approaching the desired ratio among the one or more pairs of the one or more constituents at th

Abstract: A method for regeneration of a particle filter (202) pertaining to a combustion process, which filter treats exhaust gases arising from combustion in a combustion engine (101): During regeneration, controlling the engine (101) according to a first mode and a second mode, in the first mode, the engine (101) is controlled such that a high exhaust temperature is generated, determining a temperature of the particle filter (202), and controlling the engine (101) according to the first mode when the temperature determined is below a first value until the temperature reaches a higher second value, and then controlling the engine in the second mode. The invention relates also to a system and a vehicle (100).

Abstract: A method and a system for estimation of a soot load in a particle filter in an exhaust cleaning system, which estimation involves using a pressure drop across said particle filter in order to determine the soot load. Measurement of the pressure drop across the particle filter and therefore the estimation have to take place at a time when an exhaust mass flow of the exhaust cleaning system exceeds a flow threshold value, the particle filter is substantially free from water and a temperature of the particle filter exceeds a first threshold value. The result is a robust estimate of the soot load in the particle filter.

Abstract: A method pertaining to regeneration of a particle filter (202) pertaining to a combustion process, which filter is arranged to treat exhaust gases arising from combustion in a combustion engine (101). When at least one measure for raising the temperature of the particle filter (202) is activated, determining a temperature for the particle filter (202), comparing the temperature determined with a first temperature and discontinuing the measure for raising the temperature of the particle filter (202) when the temperature determined is below the first temperature.

Abstract: A method for purifying a recombinant protein using a multimodal or mixed mode resin containing ligands which comprise a hydrophobic part and a negatively charged part is described. The invention is advantageous in that it is a single step chromatographic process which does not require adjustment of pH or conductivity during loading step and results in high yield and potency. The process is used for the purification of recombinant compositions of coagulation factor, particularly recombinant Factor VIII.

Abstract: A diesel engine system and a method for operating said system are provided. The diesel engine system includes a diesel engine provided with an exhaust conduit including a controllable supercharger located upstream of a catalytic converter, a fuel injector located between the supercharger and the catalytic converter, a diesel particulate filter located downstream of the catalytic converter, and a control unit for controlling the engine system. The control unit is arranged to determine that a regeneration of the particulate filter is required, which regeneration is initiated when a predetermined condition is fulfilled. The fuel injector is arranged to inject a predetermined amount of fuel during a first stage of the regeneration, and the supercharger is arranged to vary the flow rate of exhaust during the injection of fuel. The catalytic converter is arranged to combust the injected fuel, and the combusted fuel is arranged to burn particulates trapped within the diesel particulate filter.

Abstract: A method for purifying a recombinant protein using a multimodal or mixed mode resin containing ligands which comprise a hydrophobic part and a negatively charged part is described. The invention is advantageous in that it is a single step chromatographic process which does not require adjustment of pH or conductivity during loading step and results in high yield and potency. The process is used for the purification of recombinant compositions of coagulation factor, particularly recombinant Factor VIII.