Abstract: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is an AUG. Upstream of the VP1 open reading frame an alternative out of frame start codon is placed such that translation initiation of the VP1 protein is modified, i.e. reduced, to allow production of VP1:VP2:VP3 in a good stoichiometry resulting in AAV with high potency.

Abstract: A method for forming a transistor with an emitter, intrinsic base, and collector. The base includes a semiconductor layer doped with a conductivity dopant to provide for a lower resistivity path to the intrinsic base. After the formation of a layer over a substrate, an emitter window opening is formed in the layer. The semiconductor layer is formed through the opening by a deposition process. A portion of the semiconductor layer is then removed. An emitter electrode is formed that includes at least a portion located in the opening. A remaining portion of the semiconductor layer is in a conductive path to the intrinsic base.

Abstract: A method for providing CAM manufacturing instructions for the powder-bed-based additive manufacturing of a component wherein a geometry of the component, with a solid material region, a transition region, and a porous component region, is defined on the basis of CAD data. Irradiation parameters for the manufacturing of the component, including an irradiation power, a scanning speed, a scanning pitch, and a layer thickness, are varied within the transition region in such a way as to form a porosity gradient of the structure of the component between the solid material region of the component and the porous component region.

Abstract: A method for providing manufacturing instructions for the powder-bed-based additive manufacturing of a component includes providing first irradiation vectors for a layer to be additively manufactured, which first irradiation vectors, upon appropriate irradiation by an energy beam, in particular a laser beam or electron beam, cause a porous structure of the layer, as well as providing the first irradiation vectors for a layer which is to be additively manufactured and which follows the layer, in such a way that paths of a porous structure of the layer and of the following layer at least partially overlap in order to allow for a flow through the manufactured component along a build-up direction.

Abstract: A method for producing a support structure in the additive manufacturing of a component, includes: a) providing a geometry for the component having a region to be supported, b) providing a support structure for the region of the component, c) defining an irradiation pattern for an irradiation of layers of a raw material for the support structure, wherein surface vectors for an irradiation for a structure of the component extend into a region of the support structure, wherein common surface vectors are defined for the component and for the support structure, and d) selective irradiation of layers of the raw material for the component and the provided support structure according to the defined irradiation pattern.

Abstract: A method of additive manufacturing includes a) providing a component geometry with a hole and, b) selectively irradiating a powder bed with an energy beam according to the geometry in a layerwise manner, wherein in layers of the component including the hole, the respective regions which define the hole are irradiated with the energy beam such that a supporting structure is generated in the hole having a lower rigidity than a structure of the component. The supporting structure is used for counteracting stress or distortion during the additive buildup. A computer program product and apparatus correspond to the method.

Abstract: A transducer array for ultrasound applications includes a plurality of transducer elements that are provided with self-aligned connections to a flexible cable. The array is easy to manufacture and suited for wearable, wireless, and other small ultrasound devices. A simple and efficient method of producing a robust transducer array involves at least partially separating the transducer elements after their connection to their respective conductors.

Abstract: A component with a region to be cooled having a cooling channel which is arranged and designed so as to cool the region of the component during operation by a fluid flow, wherein the cooling channel is defined by a first channel side facing the region and by a second channel side facing away from the region. The first channel side forms a larger contact surface for the cooling channel than the second channel side. An additive manufacture process can produce the component.

Abstract: A computer-implemented method of calculating a gap distance between a support structure and a component which is to be build up additively by powder bed fusion, includes: a) providing a component design of the component, b) selecting at least on support surface of the component based on the provided component design and a process analysis, wherein the support surface requires support during the buildup, c) providing a support design of a support structure for supporting the component during the buildup, d) recording CAM-data for the buildup of the component, and, e) calculating an optimal gap distance to be hold during the buildup between the support structure and the support surface, wherein the calculation is based on the selected support surface and the recorded CAM-data, wherein the gap distance is further rated to be large enough to avoid a structural connection between the support surface and the support structure.

Abstract: The present invention relates in a first aspect to an energy efficient simplified analogue phased array transducer for ultrasound beam steering, in a second aspect to a product, such as a small wearable ultrasound device for signalling changes in a human or animal body, such as a liquid volume in a body cavity of a human or an animal, in a third aspect to a use of said device, and in a fourth aspect to a method of operating an ultrasound device.

Abstract: A method for controlling a longitudinal position of a vehicle involves a longitudinal positioning control system generating a longitudinal acceleration control signal from a longitudinal dynamic feedforward set point and from longitudinal dynamic control error quantities for a subordinate acceleration control unit acting on a drive device and braking device of the vehicle.

Abstract: This invention relates to laying nest having a rack drive expulsion system. As disclosed herein, the invention preferably comprises a laying nest for hens comprising a box and a rack drive floor expulsion system. The floor pivotably moves between first and second positions by virtue of a gear rack that is fixedly connected to and disposed within the box, and a gear wheel that is rotatably connected to the floor. Accordingly, the expulsion system provides for the selected removal of hens from the laying nests as desired.

Abstract: A method for controlling a longitudinal position of a vehicle involves a longitudinal positioning control system generating a longitudinal acceleration control signal from a longitudinal dynamic feedforward set point and from longitudinal dynamic control error quantities for a subordinate acceleration control unit acting on a drive device and braking device of the vehicle.

Abstract: A waveguide, such as an optical fiber, having a front face, such as a fiber facet, is provided with a coating. The coating having one or more organic fluorine compounds. The invention also concerns a method for producing this type of waveguide by means of plasma polymerization.

Abstract: This invention relates to laying nest having a rack drive expulsion system. As disclosed herein, the invention preferably comprises a laying nest for hens comprising a box and a rack drive floor expulsion system. The floor pivotably moves between first and second positions by virtue of a gear rack that is fixedly connected to and disposed within the box, and a gear wheel that is rotatably connected to the floor. Accordingly, the expulsion system provides for the selected removal of hens from the laying nests as desired.

Abstract: A waveguide, such as an optical fiber, having a front face, such as a fiber facet, is provided with a coating. The coating having one or more organic fluorine compounds. The invention also concerns a method for producing this type of waveguide by means of plasma polymerization.

Abstract: A device for laterally coupling pump light into a fiber. A fiber runs in a longitudinal direction, having an optically active medium to be pumped and a lateral wall running approximately in the longitudinal direction, and at least one light coupler, at least some part of which runs parallel to the fiber along the lateral wall. The light coupler is an optical waveguide which is optically coupled to the fiber such that pump light propagating in the optical waveguide can be coupled into the fiber via the lateral wall. The efficiency of the pump light coupling is improved by a plurality of windings of the fiber being located alternately with waveguides on a substrate. The pump light can be coupled into all waveguides simultaneously, for example by a prism.

Abstract: A laying nest comprising boxes (12) having at least a bottom (24), sidewalls (18), a back wall (22), and a roof (20). Further, the laying nest comprises an expulsion system which comprises a shaft (26) which is provided with at least one gear wheel which is fixedly connected with the shaft. An expulsion plate of the expulsion system is rotatably connected with the shaft and via a support shaft is pivotably and slidably connected with the box. The expulsion system further comprises a gear rack (34) which is fixedly arranged in the box and which is configured for cooperation with the gear wheel, such that upon rotation of the shaft, this shaft moves along the gear rack, thereby carrying along the expulsion plate.

Abstract: A device for laterally coupling pump light into a fiber. A fiber runs in a longitudinal direction, having an optically active medium to be pumped and a lateral wall running approximately in the longitudinal direction, and at least one light coupler, at least some part of which runs parallel to the fiber along the lateral wall. The light coupler is an optical waveguide which is optically coupled to the fiber such that pump light propagating in the optical waveguide can be coupled into the fiber via the lateral wall. The efficiency of the pump light coupling is improved by a plurality of windings of the fiber being located alternately with waveguides on a substrate. The pump light can be coupled into all waveguides simultaneously, for example by a prism.

Abstract: A laying nest comprising boxes (12) having at least a bottom (24), sidewalls (18), a back wall (22), and a roof (20). Further, the laying nest comprises an expulsion system which comprises a shaft (26) which is provided with at least one gear wheel which is fixedly connected with the shaft. An expulsion plate of the expulsion system is rotatably connected with the shaft and via a support shaft is pivotably and slidably connected with the box. The expulsion system further comprises a gear rack (34) which is fixedly arranged in the box and which is configured for cooperation with the gear wheel, such that upon rotation of the shaft, this shaft moves along the gear rack, thereby carrying along the expulsion plate.