Abstract: The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.

Abstract: The present invention relates to biomarkers that are useful in the prognosis of triple negative breast cancer patients. The biomarkers may be used to select treatment and to determine whether a treatment is effective or not. The biomarkers may also be used to select novel treatments and to screen for new potential compounds that may treat the triple negative breast cancer.

Abstract: A method and an apparatus for correlating two image sequences of a periodically moving object with respect to the periodicity is described. A first frame sequence of the object moving with the first periodicity is acquired. Therein the first frame sequence comprises at least one cycle of motion. A second frame sequence of the object moving with the second periodicity is acquired. Therein the second frame sequence comprises at least one cycle of motion. The first and the second frame sequences are synchronized with respect to the respective periodicity such that same phases of motion of the periodically moving object are correlated to be presented simultaneously. The present invention allows to compare sequences representing a periodical motion with a different number of frames in each of the sequences for the same cycle of motion. Thereby, e.g. image sequences of a beating heart acquired before and after a therapy may be presented in a synchronized way and therefore may be easily compared.

Abstract: A compact gas discharge lamp (301) comprising four (or more) interconnected tube segments (11, 12, 13, 14) is provided with an external electrode (310) that extends at least throughout the length of the tube segments and that is in contact with all tube segments. Several embodiments of the external electrode are disclosed. The external electrode is preferably connected to a node (C) midway between the lamp electrodes, to which end a capacitive divider (441, 442) is arranged in parallel with the lamp.

Abstract: The present invention relates to a method for diagnosing cancer in a subject said method comprising the steps of providing a biological sample from a subject, and determining the expression of the MCAM gene in a circulating tumor cell (CTC) in said biological sample.

Abstract: The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with breast cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles in samples obtained from patients diagnosed with breast cancer.

Abstract: A method and an apparatus for correlating two image sequences of a periodically moving object with respect to the periodicity is described. A first frame sequence of the object moving with the first periodicity is acquired. Therein the first frame sequence comprises at least one cycle of motion. A second frame sequence of the object moving with the second periodicity is acquired. Therein the second frame sequence comprises at least one cycle of motion. The first and the second frame sequences are synchronized with respect to the respective periodicity such that same phases of motion of the periodically moving object are correlated to be presented simultaneously. The present invention allows to compare sequences representing a periodical motion with a different number of frames in each of the sequences for the same cycle of motion. Thereby, e.g. image sequences of a beating heart acquired before and after a therapy may be presented in a synchronised way and therefore may be easily compared.

Abstract: A lithographic apparatus arranged to transfer a pattern onto a substrate is disclosed. The lithographic apparatus comprises a power supply and an electrical connector. The electrical connector electrically connects the power supply to another component of the lithographic apparatus. The electrical connector comprises a laminate that comprises, in order, a first conducting layer, a first flexible insulating layer, a conductor configured to carry an electrical current, a second flexible insulating layer and a second conducting layer.

Abstract: A compact gas discharge lamp (301) comprising four (or more) interconnected tube segments (11, 12, 13, 14) is provided with an external electrode (310) that extends at least throughout the length of the tube segments and that is in contact with all tube segments. Several embodiments of the external electrode are disclosed. The external electrode is preferably connected to a node (C) midway between the lamp electrodes, to which end a capacitive divider (441, 442) is arranged in parallel with the lamp.

Abstract: A system and method of generating a template of at least one artifact for use in image correction is disclosed. An image containing the artifact is generated using at least two homogeneous exposures, each generated at a different detector operating temperature. The local variance of grey values at each pixel position in the image is calculated. Each pixel in the image is then classified. A binary image is generated based on the classification. The template is then formed based on both the binary image and the image data containing the artifact.

Abstract: The invention provides a semiconductor device (11) for radiation detection in a semiconductor substrate (1) comprising a detection region (3), which detects charge carriers that are generated upon incidence of radiation (X, L) on the semiconductor device (11). The semiconductor device further (11) comprises a further detection region (13), which detects charge carriers that are generated upon incidence of radiation (X) on the semiconductor device (11). A shield (8, 18) extends over the further detection region (13), which prevents electromagnetic radiation (L) from entering the detection region (13). This way the invention provides a semiconductor device (11) for radiation detection in which the separation between the detection of electromagnetic radiation (L) and the detection of other radiation is improved.

Abstract: A lithographic apparatus comprises a patterning device, a projection system, and a controller. The patterning device is configured to pattern a beam of radiation. The radiation beam comprises a plurality of pulses of radiation. The projection system is configured to project the patterned beam of radiation onto a substrate coated with a layer of radiation sensitive material. The controller is arranged to control a total energy of a respective pulse of the plurality of pulses of the radiation beam. The controller is configured to take into account information indicative of properties of the layer of radiation sensitive material on a part of the substrate onto which the radiation beam is to be projected.

Abstract: The invention relates to a method of and a device for forming an image which is composed of a plurality of sub-areas, a read-out unit being associated with each sub-area and image data of adjoining image areas of neighboring sub-areas being evaluated in order to mitigate differences in amplification, which device includes a detector with a plurality of sensor elements for forming image data, read-out units which are associated with the sub-areas of the image, an analysis unit which is arranged to evaluate image data from adjoining image areas of neighboring sub-areas and to generate correction data, a correction unit which is arranged to correct incorrect image data by means of correction data, thus enabling a regular and accurate recalibration or correction of non-linear amplifier behavior to be performed without necessitating an additional X-ray dose or interventions by the user.

Abstract: The invention relates to a method of and a device for forming an image which is composed of a plurality of sub-areas, a read-out unit being associated with each sub-area and image data of adjoining image areas of neighboring sub-areas being evaluated in order to mitigate differences in amplification, which device includes a detector with a plurality of sensor elements for forming image data, read-out units which are associated with the sub-areas of the image, an analysis unit which is arranged to evaluate image data from adjoining image areas of neighboring sub-areas and to generate correction data, a correction unit which is arranged to correct incorrect image data by means of correction data, thus enabling a regular and accurate recalibration or correction of non-linear amplifier behavior to be performed without necessitating an additional X-ray dose or interventions by the user.

Abstract: The invention relates to an oven for sealing a panel to a funnel, thus forming an envelope suitable for use in a display tube, comprising a tunnel structure 9 and at least one mount for conveying an assembly of a panel and a funnel through the tunnel structure 9. The tunnel structure 9 is provided with a longitudinal slot 16A and the components of the mount for guiding the mount along and through the tunnel structure 9 are placed outside the tunnel structure. It is preferred that the components comprise a means, such as a pump or compressor 24, for flushing the interior of the assembly 22 with a fluid obtained from a source which is substantially separated from the gas(es) circulating in the oven 1, e.g. from the surroundings of the oven 1.

Abstract: The invention relates to a sampling container for taking samples from a tank containing a flammable liquefied gas. The container comprises an inlet opening and an outlet opening, at least two valves for operating the openings, and a connector at the inlet opening for establishing fluid communication with the tank. A nozzle which communicates with the inlet opening and which suppresses the splashing of liquefied gas flowing into the sampling container and hence the build-up of static electricity. The invention further pertains to an apparatus for taking samples from a tank containing a flammable liquefied gas, comprising a first connector-counterpart for receiving the connector of the sampling container.

Abstract: The invention relates to an oven for sealing a panel to a funnel, thus forming an envelope suitable for use in a display tube, comprising a tunnel structure 9 and at least one mount for conveying an assembly of a panel and a funnel through the tunnel structure 9. The tunnel structure 9 is provided with a longitudinal slot 16A and the components of the mount for guiding the mount along and through the tunnel structure 9 are placed outside the tunnel structure. It is preferred that the components comprise a means, such as a pump or compressor 24, for flushing the interior of the assembly 22 with a fluid obtained from a source which is substantially separated from the gas(es) circulating in the oven 1, e.g. from the surroundings of the oven 1.

Abstract: The invention relates to a method of and a device for forming an image which is composed of a plurality of sub-areas, a read-out unit being associated with each sub-area and image data of adjoining image areas of neighboring sub-areas being evaluated in order to mitigate differences in amplification, which device includes a detector with a plurality of sensor elements for forming image data, read-out units which are associated with the sub-areas of the image, an analysis unit which is arranged to evaluate image data from adjoining image areas of neighboring sub-areas and to generate correction data, a correction unit which is arranged to correct incorrect image data by means of correction data, thus enabling a regular and accurate recalibration or correction of non-linear amplifier behavior to be performed without necessitating an additional X-ray dose or interventions by the user.