Patents by Inventor Johannes Bartholomäus

Johannes Bartholomäus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
    Publication number: 20160184297
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: March 4, 2016
    Publication date: June 30, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes Bartholomäus, Heinrich Kugelmann
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20160175256
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20160166517
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 16, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS, HEINRICH KUGELMANN
  • PROLONGED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)PHENOL
    Publication number: 20160151309
    Abstract: A pharmaceutical formulation for prolonged release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Inventors: Johannes BARTHOLOMAEUS, Iris Ziegler
  • CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
    Publication number: 20160120810
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 5, 2016
    Applicant: Grünenthal GmbH
    Inventors: Judy Ashworth, Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20160101022
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: November 25, 2015
    Publication date: April 14, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20160074388
    Abstract: The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 17, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU MARIC
  • Hormonal contraceptive containing a combination of ethinyloestradiol and chlormadinone acetate
    Patent number: 9278072
    Abstract: The present invention relates to a hormonal contraceptive including 21 to 25 hormone-containing daily units, which contain a combination of ethinyloestradiol in an amount of ?25 ?g and chlormadinone acetate in an amount of ?5 mg, and optionally 7 to 3 hormone-free daily units for oral administration to women.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: March 8, 2016
    Assignee: Richter Gedeon Nyrt.
    Inventors: Janine Klose, Johannes Bartholomäus, Klaus-Michael Wilsmann, Georg Schramm
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20160058710
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: November 9, 2015
    Publication date: March 3, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20160022588
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: October 5, 2015
    Publication date: January 28, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20160022587
    Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: October 5, 2015
    Publication date: January 28, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMAEUS, Heinrich KUGELMANN
  • Crush resistant delayed-release dosage forms
    Publication number: 20150374630
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: September 9, 2015
    Publication date: December 31, 2015
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Judy ASHWORTH
  • OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM
    Publication number: 20150366809
    Abstract: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
    Type: Application
    Filed: September 1, 2015
    Publication date: December 24, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Lutz BARNSCHEID, Eric GALIA, Sebastian SCHWIER, Ulrike BERTRAM, Anja GEISSLER, Kornelia GRIESSMANN, Johannes BARTHOLOMÄUS
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150359747
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: August 25, 2015
    Publication date: December 17, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS, HEINRICH KUGELMANN
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20150313845
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: July 10, 2015
    Publication date: November 5, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • Crush resistant delayed-release dosage forms
    Publication number: 20150290138
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150283086
    Abstract: The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
    Type: Application
    Filed: June 22, 2015
    Publication date: October 8, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20150216821
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: April 14, 2015
    Publication date: August 6, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20150182465
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: March 13, 2015
    Publication date: July 2, 2015
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth Arkenau Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20150182464
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: March 13, 2015
    Publication date: July 2, 2015
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN