Patents by Inventor Johannes Bartholomäus

Johannes Bartholomäus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Plaster causing reduced skin irritation
    Patent number: 9066888
    Abstract: A plaster containing an active ingredient for the transdermal administration of a pharmaceutical active ingredient, having a removable protective film and an adhesive layer. The plaster includes at least one compound that is contained in the adhesive layer or lies adjacent the adhesive layer between the adhesive layer and the removable protective film and that can be applied to the skin to at least reduce skin irritation.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: June 30, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Heinrich Kugelmann, Johannes Bartholomäus, Rasoul Sedaghat Kerdar
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150164811
    Abstract: The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.
    Type: Application
    Filed: December 23, 2014
    Publication date: June 18, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS
  • DOSAGE THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20150150978
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: February 10, 2015
    Publication date: June 4, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150091201
    Abstract: The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150056147
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMAEUS, HEINRICH KUGELMANN
  • Method for the production of a form of administration of a medicament
    Patent number: 8939748
    Abstract: The present invention relates to a device for cutting a strand to a length with regard to a weight and to the use of such device in a method for producing a medicament dosage form of at least one piece composed of at least one medicament and at least one additive, the medicament and the additive being mixed and extruded from a die as a strand and the strand being cut into pieces of precise weight using the device.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: January 27, 2015
    Assignee: Grünenthal GmbH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Dieter Schateikis, Kai-Uwe Ustorf
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20150024046
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 22, 2015
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • DOSAGE THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20140356294
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: August 13, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • Star distributor
    Patent number: 8894904
    Abstract: The present invention relates to a device for distributing tablet blanks to the dies of a tablet press. The present invention moreover relates to a system consisting of the device according to the invention and a tablet press and to a method for forming tablets from tablet blanks.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: November 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Dieter Schateikis, Elisabeth Arkenau-Maric, Johannes Bartholomäus
  • CRUSH RESISTAN DELAYED-RELEASE DOSAGE FORM
    Publication number: 20140322311
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Applicant: Grünenthal GmbH
    Inventors: Judy Ashworth, Elisabeth Arkenau Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • PHARMACEUTICAL DOSAGE FORM
    Publication number: 20140322323
    Abstract: The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
    Type: Application
    Filed: April 25, 2014
    Publication date: October 30, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: EUGEEN MARIE JOZEF JANS, FILIP RENÉ IRENA KIEKENS, JODY FIRMIN MARCELINE VOORSPOELS, ANNE FAURE, IRIS ZIEGLER, ELISABETH ARKENAU-MARIC, LUTZ BARNSCHEID, JOHANNES BARTHOLOMÄUS, MARC FREVEL, ERIC GALIA, ANDREA SCHÜESSELE
  • OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM
    Publication number: 20140194455
    Abstract: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
    Type: Application
    Filed: February 28, 2014
    Publication date: July 10, 2014
    Applicant: GRUNENTHAL GMBH
    Inventors: Lutz BARNSCHEID, Eric GALIA, Sebastian SCHWIER, Ulrike BERTRAM, Anja GEISSLER, Kornelia GRIESSMANN, Johannes BARTHOLOMÄUS
  • METHOD FOR THE PRODUCTION OF A FORM OF ADMINISTRATION OF A MEDICAMENT
    Publication number: 20140191432
    Abstract: The present invention relates to a method for producing a medicament dosage form which consists of at least one piece which in each case comprises at least one medicament and at least one additive, the medicament and the additive being mixed and extruded from a die as a strand and the strand being cut into pieces of precise weight. The invention additionally relates to a device.
    Type: Application
    Filed: March 11, 2014
    Publication date: July 10, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Dieter SCHATEIKIS
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20140170079
    Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: December 23, 2013
    Publication date: June 19, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMAEUS, Heinrich KUGELMANN
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20140155489
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: February 7, 2014
    Publication date: June 5, 2014
    Applicant: GRUNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20140147499
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: January 30, 2014
    Publication date: May 29, 2014
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • Dosage form with impeded abuse
    Patent number: 8722086
    Abstract: A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: May 13, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Elisabeth Arkenau-Marić, Johannes Bartholomaeus, Iris Ziegler, Marcel Haupts
  • Crush resistant delayed-release dosage forms
    Publication number: 20140112984
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: December 27, 2013
    Publication date: April 24, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20140112989
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: December 30, 2013
    Publication date: April 24, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes Bartholomäus, Heinrich Kugelmann, Elisabeth Arkenau Maric
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
    Publication number: 20140113926
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking strength of ?500 N, by exposing a mixture comprising the active ingredient and the binder to ultrasound and force.
    Type: Application
    Filed: December 30, 2013
    Publication date: April 24, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth Arkenau Maric, Johannes Bartholomäus