Patents by Inventor Johannes-Peter Stasch

Johannes-Peter Stasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use
    Patent number: 7504421
    Abstract: The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: March 17, 2009
    Inventors: Ulrich Rosentreter, Rolf Henning, Marcus Bauser, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Klaus Dembowsky, Olga Salcher-Schraufstatter, Johannes-Peter Stasch, Thomas Krahn, Elisabeth Perzborn
  • MORPHINE-BRIDGED INDAZOLE DERIVATIVES
    Publication number: 20090023717
    Abstract: The present invention relates to novel morpholine-bridged indazole derivatives which stimulate soluble guanylate cyclase, to process for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of disorders of the central nervous system.
    Type: Application
    Filed: September 18, 2008
    Publication date: January 22, 2009
    Inventors: Achim Feurer, Joachim Luithle, Stephan-Nicholas Wirtz, Gerhard Konig, Johannes-Peter Stasch, Frank Wunder, Dieter Lang, Elke Stahl, Thomas Schenke, Rudy Schreiber
  • Substituted Phenylamino-Pyrimidines
    Publication number: 20080269268
    Abstract: The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
    Type: Application
    Filed: April 14, 2005
    Publication date: October 30, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Hartmut Schirok, Johannes-Peter Stasch, Raimund Kast, Klaus Munter, Mark Jean Gnoth, Santiago Figureoa Perez, Michael Thutewohl, Samir Bennabi, Dieter Lang, Joachim Mittendorf, Martin Radtke, Heimo Ehmke
  • Pyrrolopyridine-Substituted Benzol Derivatives for Treating Cardiovascular Diseases
    Publication number: 20080249105
    Abstract: The invention relates to heteroaryl-substituted benzenes, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
    Type: Application
    Filed: November 26, 2004
    Publication date: October 9, 2008
    Applicant: Bayer Healthcare AG
    Inventors: Samir Bennabi, Heike Heckroth, Hartmut Schirok, Joachim Mittendorf, Raimund Kast, Johannes-Peter Stasch, Mark Jean Gnoth, Klaus Minter, Dieter Lang, Santiago Figueroa Perez, Marcus Bauser, Achim Feurer, Heimo Ehmke
  • Morpoline-bridged indazole derivatives
    Patent number: 7427617
    Abstract: The present invention relates to novel morpholine-bridged indazole derivatives having the formula which stimulate soluble guanylate cyclase, to a process for the preparation thereof, and to pharmaceutical compositions containing them. These compounds are useful for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: September 23, 2008
    Assignee: Bayer Healthcare AG
    Inventors: Achim Feurer, Joachim Luithle, Stephan-Nicholas Wirtz, Gerhard König, Johannes-Peter Stasch, Frank Wunder, Dieter Lang, Elke Stahl, Thomas Schenke, Rudy Schreiber
  • 4-amino-substituted pyrimidine derivatives
    Patent number: 7410973
    Abstract: The present invention relates to novel 4-amino-substituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of central nervous system diseases.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: August 12, 2008
    Assignee: Bayer Healthcare AG
    Inventors: Achim Feurer, Joachim Luithle, Stephan-Nicholas Wirtz, Gerhard König, Johannes-Peter Stasch, Elke Stahl, Rudy Schreiber, Frank Wunder, Dieter Lang
  • Method For Treating Bronchoconstriction and Pulmonary Vaso-Constriction
    Publication number: 20080138444
    Abstract: This invention relates to the treatment and prevention of asthma or other forms of broncho-constriction or reversible pulmonary vasoconstriction in a mammal.
    Type: Application
    Filed: September 23, 2005
    Publication date: June 12, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Stefan Weigand, Reiner Frey, Johannes-Peter Stasch
  • Hetaryloxy-Substituted Phenylamino Pyrimidines as Rho Kinase Inhibitors
    Publication number: 20080139595
    Abstract: The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
    Type: Application
    Filed: March 30, 2005
    Publication date: June 12, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Hartmut Schirok, Martin Radtke, Joachim Mittendorf, Raimund Kast, Johannes-Peter Stasch, Mark Jean Gnoth, Klaus Munter, Dieter Lang, Santiago Figueroa Perez, Michael Thutewohl, Samir Bennabi, Heimo Ehmke
  • Novel dicarboxylic acid derivatives with pharmaceutical properties
    Publication number: 20080058314
    Abstract: The present invention relates to the use of compounds of the formula (I) and to their salts and stereoisomers, for the preparation of medicaments for the treatment of cardiovascular disorders.
    Type: Application
    Filed: June 27, 2007
    Publication date: March 6, 2008
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl
  • Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis
    Patent number: 7329777
    Abstract: This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several variables are as defined in the specification and claims.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: February 12, 2008
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Harter, Michael Hahn, Claudia Hirth-Dietrich, Andreas Knorr, Elke Stahl, Johannes-Peter Stasch, Frank Wunder
  • Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives
    Patent number: 7317016
    Abstract: This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein R1 is a radical of the formula —O—SO2—R3 in which R3 is optionally substituted C1-6-alkyl, optionally substituted C3-8-cycloalkyl, or optionally substituted phenyl; R2 is H, optionally substituted C1-6-alkyl-CO— or optionally substituted C1-6-alkyl-SO2—; as well as salts, stereoisomers, tautomers, and hydrates thereof.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: January 8, 2008
    Assignee: Bayer Aktiengesellschaft
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elisabeth Perzborn
  • Medical uses of carbamate-substituted pyrazolo-pyridine derivatives
    Patent number: 7291622
    Abstract: This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula wherein R1 is H or a di-C1-6-alkylaminocarbonyl radical, and R2 is a radical of the formula —O—C(X)—NR3R4 wherein X is O or S. The compound may also be administered in combination with at least one organic nitrate or NO donor, or in combination with at least one compound which inhibits the breakdown of cyclic guanosine monophosphate (cGMP).
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: November 6, 2007
    Assignee: Bayer Aktiengesellschaft
    Inventors: Johannes-Peter Stasch, Achim Feurer, Stefan Weigand, Elke Stahl, Dietmar Flubacher, Cristina Alonso-Alija, Frank Wunder, Dieter Lang, Klaus Dembowsky, Alexander Straub, Elizabeth Perzborn
  • Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance
    Publication number: 20070225299
    Abstract: A combination product which comprises as pharmaceutically active ingredients at least one active ingredient component A and at least one active ingredient component B, where active ingredient component A is a direct soluble guanylate cyclase stimulator of the formula (I) and active ingredient component B is a lipid-lowering agent, is described and claimed. Methods for treating various conditions using combination therapy are also claimed.
    Type: Application
    Filed: October 26, 2004
    Publication date: September 27, 2007
    Applicant: Bayer Healthcare AG
    Inventors: Hilmar Bischoff, Johannes-Peter Stasch, Stefan Weigand
  • Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands
    Publication number: 20070213372
    Abstract: The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
    Type: Application
    Filed: December 1, 2006
    Publication date: September 13, 2007
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch
  • Substituted aminodicarboxylic acid derivatives having pharmaceutical properties
    Publication number: 20070179139
    Abstract: The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.
    Type: Application
    Filed: October 10, 2006
    Publication date: August 2, 2007
    Applicant: Bayer Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Michael Harter, Michael Hahn, Josef Pernerstorfer, Stefan Weigand, Johannes-Peter Stasch, Frank Wunder
  • Relaxin as an independent risk factor predicting mortality
    Publication number: 20070166757
    Abstract: Disclosed are methods of characterising life expectancy of human individuals on the basis of measured relaxin levels. In one aspect of the invention the human individuals are end-stage-kidney-disease patients.
    Type: Application
    Filed: May 25, 2004
    Publication date: July 19, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Johannes-Peter Stasch, Mathias Gehrmann, Berthold Hocher
  • Carbamate-substituted pyrazolopyridines
    Patent number: 7173037
    Abstract: The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: February 6, 2007
    Assignee: Bayer HealthCare AG
    Inventors: Cristina Alonso-Alija, Erwin Bischoff, Klaus Münter, Johannes-Peter Stasch, Elke Stahl, Stefan Weigand, Achim Feurer
  • Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use
    Publication number: 20060264432
    Abstract: The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
    Type: Application
    Filed: February 21, 2006
    Publication date: November 23, 2006
    Inventors: Ulrich Rosentreter, Rolf Henning, Marcus Bauser, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Klaus Dembowsky, Olga Salcher-Schraufstatter, Johannes-Peter Stasch, Thomas Krahn, Elisabeth Perzborn
  • Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof
    Patent number: 7135486
    Abstract: This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, pharmaceutical compositions containing them, and methods of treating a cardiovascular disorder by administering them to a patient are also disclosed and claimed.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: November 14, 2006
    Assignee: Bayer Aktiengeselischaft
    Inventors: Ulrich Rosentreter, Rolf Henning, Marcus Bauser, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Klaus Dembowsky, Olga Salcher-Schraufstätter, Johannes-Peter Stasch, Thomas Krahn, Elisabeth Perzborn
  • Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators
    Patent number: 7135474
    Abstract: This application relates to compounds of the formula (I) in which R1 is chlorine, cyano, trifluoromethyl or methoxy and R2 is hydrogen or flurorine; or R1 and R2 are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: November 14, 2006
    Assignee: Bayer Healthcare AG
    Inventors: Stefan Weigand, Erwin Bischoff, Klaus Münter, Johannes-Peter Stasch, Elke Stahl