Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: A system for tracking a moving target having up to six degrees of freedom and rapidly determining positions of the target, said system includes an easy to locate precision optical target fixed to the target. This system includes at least two cameras positioned so as to view the optical camera from different directions with each of the at least two cameras being adapted to record two dimensional images of the precision optical target defining precise target point. A computer processor is programmed to determine the target position of x, y and z and pitch, roll and yaw. In an embodiment, the system can be configured to utilize an iteration procedure whereby an approximate first-order solution is proposed and tested against the identified precise target points to determine residual errors which can be divided by the local derivatives with respect to each component of rotation and translation, to determine an iterative correction.

Abstract: Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.

Abstract: An improved supercapacitor includes a first and second electrode with each electrode made at least in part from a highly-porous electrically conductive material, a insulative separator separating the electrodes; a first electrically conductive current collector in physical and electrical contact with the first electrode; and a second electrically conductive current collector in physical and electrical contact with the second electrode, wherein at least one current collector is configured to have multiple separate portions with each portion having a current capacity that varies as a function of current passing through during capacitive operation.

Abstract: Disclosed herein is a process for carrying out an ion exchange process which involves providing two interacting sets of banks of continuously stirred tank reactors (CSTR's) each containing a bed of ion exchange resin and causing the resin to move in one direction through each bank of reactors and the feed solution and/or or eluant in the opposite direction. In carrying out the process, a feed solution is introduced in a first reactor causing dissolved ions to be captured on the resin, eluant is introduced into a reactor upstream of the first reactor in the direction of resin movement causing ions captured on the resin to be removed into the eluant and eluant rich in ions removed from the resin will be taken from a reactor upstream of the reactor in which the eluant was introduced, for further processing.

Abstract: A sample fluid stream can be received from a main fluid stream through a nozzle of a probe located at least partially in the main fluid stream. The sample fluid stream can travel into the nozzle and a portion of the main fluid stream adjacent to the sample fluid stream can flow past the probe without entering the probe. The sample fluid stream can flow downstream within the probe, and a portion of the main fluid stream can flow downstream outside the probe. While receiving the sample fluid stream, a gas sheet can be directed from the probe, with the gas sheet flowing upstream against the main fluid stream.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The disclosure discloses methods, devices, systems and kits for repairing, replacing and/or augmenting natural facet joint surfaces and/or facet capsules. An implantable facet joint device of one embodiment comprises a cephalad facet joint element and a caudal facet joint element. The cephalad facet joint element includes a member adapted to engage a first vertebra, and an artificial cephalad bearing member. The caudal facet joint element includes a connector adapted for fixation to a second vertebra at a fixation point and an artificial caudal bearing member adapted to engage the cephalad bearing member. The artificial caudal bearing member is adapted for a location lateral to the fixation point.

Abstract: A thin-film coating applicator assembly is disclosed for coating substrates in outdoor applications. The innovative thin-film coating applicator assembly is adapted to apply performance enhancement coatings on installed photovoltaic panels and glass windows in outdoor environments. The coating applicator is adapted to move along a solar panel or glass pane while applicator mechanisms deposit a uniform layer of liquid coating solution to the substrate's surface. The applicator assembly comprises a conveyance means disposed on a frame. Further disclosed are innovative applicator heads that comprise a deformable sponge-like core surrounded by a microporous layer. The structure, when in contact with a substrate surface, deposits a uniform layer of coating solution over a large surface.

Abstract: The invention describes a method of ozone titration sensing which utilizes an ozone addition to a target solution, detection of ozone using an Oxidation-Reduction Potential (ORP) electrode or an Ultraviolet (UV) absorption photodiode or other means to detect ozone and the determination of the relative concentration of organics or pathogens subject to ozone oxidation which are present in the target solution. The inventive sensing method can be usefully employed to determine the relative concentration of pathogens such as viruses, bacteria and/or parasites that are readily oxidizable by ozone in aqueous solutions. The inventive sensing method may be used to control an ozone (or other oxidizing or disinfecting) compound dispensing system to optimize the dosage of ozone (or other disinfecting compound) necessary to produce a desired kill ratio or to generate a desired residual of ozone concentration in an aqueous solution after pathogen disinfection.

Abstract: A novel durable composite diamond electrode comprising at least a relatively thicker conductive layer of UNCD (Ultrananocrystalline Diamond) layer with a Young's modulus of less than 900 GPa on a niobium substrate underlying a relatively thinner conductive MCD (Microcrystalline Diamond) layer with a Young's modulus of greater than 900 GPa, has been shown to exhibit superior delamination resistance under extreme shear stress during electrochemical oxidation reliability testing. Highly accelerated lifetime testing of these durable composite diamond electrodes at a constant current density of 2.5 amps/cm2 (25000 amps/m2) in a 1 M NaCl (58 g/L) solution, have demonstrated lifetimes before delamination failure of greater than 2000 hours (i.e. >5000 Ahr/cm2). Using a conservative estimate of lifetime to failure with a cubed dependence on current density, the lifetime at a more typical operating current density of 0.25 amps/cm2 (2500 amps/m2) would be at least 2,000,000 hours (228 years) and >3.5 years at 1.

Abstract: The present invention relates to new extended release pharmaceutical compositions and methods of use thereof for the treatment of disorders. In certain embodiments, disclosed herein is an extended-release pharmaceutical formulation comprising, in a solid dosage form for oral delivery of between about 100 mg and about 1 g total weight: between about 2 and about 18% of an active ingredient; between about 70% and about 96% of one or more diluents; between about 1% and about 10% of a water-soluble binder and between about 0.5 and about 2% of a surfactant.

Abstract: The present invention relates to an apparatus for the production of ozone from water comprising at least one cell, consisting of an anode, a cathode and an interposed cation-conducting membrane, wherein the membrane conductively connects the anode and the cathode while forming flow channels for water that are separated from one another as anode and cathode chambers and wherein the flow channels are configured to allow for the recirculation of the water flow within the chambers. The present invention further relates to an electrochemical method and apparatus for producing ozone or dissolved ozone in water in high concentrations by mean of recirculation of water between at least one chamber and at least one water tank.

Abstract: A novel composite diamond film comprising of a relatively thick layer of UNCD (Ultrananocrystalline Diamond) with a Young's modulus of less than 900 GPa and an underlying relatively thin MCD (microcrystalline diamond) layer with a Young's modulus of greater than 900 GPa, has been shown to exhibit superior delamination resistance under extreme shear stress. It is hypothesized that this improvement is due to a combination of stress relief by the composite film with a slightly “softer” UNCD layer, a disruption of the fracture mechanism through the composite layer(s), and the near ideal chemical and thermal expansion coefficient match between the two diamond layers. The combination of a thick but “softer” underlying UNCD layer with a thin but harder overlying MCD layer provides an excellent compromise between the low deposition cost and smoothness of UNCD with the extreme hardness and unparalleled chemical, electrochemical and immunological inertness of even a thin layer of MCD.

Abstract: The present invention relates to a sports device, such as a surf board, water board, and the like for use by persons in moving over a water surface. The device generally has: a) a central foam core; b) a cover fabric laminated around the central foam core; c) a laminating adhesive securing the cover fabric to the central foam core; and d) a water resistant polymeric coating covering the laminated cover fabric and laminating adhesive. The laminating adhesive generally has a specific gravity of less than 2.0 g/m3. The laminating adhesive may have a Shore A hardness of at least 70 and may be a water-based polyurethane emulsion, a methacrylate-acrylate copolymer emulsion, an epoxy or epoxy-acrylate hybrid emulsion adhesive or a mixture of at least any two of these adhesives.

Abstract: The present invention relates to a sports device, such as a surf board, water board, and the like for use by persons in moving over a water surface. The device generally has: a) a central foam core; b) a cover fabric laminated around the central foam core; c) a laminating adhesive securing the cover fabric to the central foam core; and d) a water resistant polymeric coating covering the laminated cover fabric and laminating adhesive. The laminating adhesive generally has a specific gravity of less than 2.0 g/m3. The laminating adhesive may have a Shore A hardness of at least 70 and may be a water-based polyurethane emulsion, a methacrylate-acrylate copolymer emulsion, an epoxy or epoxy-acrylate hybrid emulsion adhesive or a mixture of at least any two of these adhesives.

Abstract: Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound.

Abstract: Methods of increasing the biological activity of toxins. Methods of increasing the biological activity of pesticide toxins through the incorporation of pro-regions into nucleic acid constructs for the production of said toxins.

Abstract: The technology disclosed relates to manipulating and visualizing database objects that represent layers and parts of layers in an insurance or other risk transfer program. In particular, a special purpose database system replaces manual use of spreadsheets and supports data visualization. The technology disclosed provides systems and methods for processing and displaying database objects that build a composite coverage structure capable of representing a complex program of multiple insurance policies or other risk transfer instruments during planning and placement. Reporting from the database of progress against the composite coverage structure and updating objects using a visual interface are described.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.