Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: Systems and methods for a mass spectrometer include an atmospheric-pressure chemical ionization (APCI) source, one or more low-pressure chemical ionization (LPCI) sources, a mass analyzer configured to separate ions of a sample flow from the APCI source and the one or more LPCI sources, a detector configured to identify and quantify the received separated ions, and a plurality of valves configured to open and close associated input lines to the APCI source and the one or more LPCI sources, via a computer-implemented controller, and configured to maintain a vacuum environment of the mass spectrometer during the opening and closing.

Abstract: The invention discloses methods, devices, systems and kits for repairing, replacing and/or augmenting natural facet joint surfaces and/or facet capsules. An implantable facet joint device of one embodiment comprises a cephalad facet joint element and a caudal facet joint element. The cephalad facet joint element includes a member adapted to engage a first vertebra, and an artificial cephalad bearing member. The caudal facet joint element includes a connector adapted for fixation to a second vertebra at a fixation point and an artificial caudal bearing member adapted to engage the cephalad bearing member. The artificial caudal bearing member is adapted for a location lateral to the fixation point.

Abstract: A system for tracking a moving target having up to six degrees of freedom and rapidly determining positions of the target, said system includes an easy to locate precision optical target fixed to the target. This system includes at least two cameras positioned so as to view the optical camera from different directions with each of the at least two cameras being adapted to record two dimensional images of the precision optical target defining precise target point. A computer processor is programmed to determine the target position of x, y and z and pitch, roll and yaw. In an embodiment, the system can be configured to utilize an iteration procedure whereby an approximate first-order solution is proposed and tested against the identified precise target points to determine residual errors which can be divided by the local derivatives with respect to each component of rotation and translation, to determine an iterative correction.

Abstract: An axle seal used to prevent lubricant from leaking between a rotating shaft and a shaft bore, for example, sealed fittings between the rotating shaft and shaft bore where static misalignment and/or dynamic misalignment exceeds conventional extent. The seal includes: a peripheral connection section reliably connected to an inner edge of the shaft bore; an extensible and retractable adjustment section connected to the peripheral connection section, allowing the seal to make extension and retraction adjustment in a radial direction; and a sealed contact section connected to the inner edge of the extensible and retractable adjustment section and potentially in sealed contact with the surface of the rotating shaft. The seal contains an alignment follower that can synchronously transfer a radial movement of the rotating shaft to the inner edge of the extensible and retractable adjustment section. One application would be an oil seal between a front cover and crankshaft.

Abstract: The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding a protein comprising the sequence of a first chaperone protein, a second recombinant gene encoding a protein comprising the sequence of a second chaperone protein and a third gene, such as a third recombinant gene, encoding a desired protein (such as a desired heterologous protein), wherein the first and second chaperones are different; and (b) culturing the host cell in a culture medium to obtain expression of the first, second and third genes.

Abstract: Provided herein is technology relating to genetically modified organisms and particularly, but not exclusively, to compositions comprising one or more genetically modified microorganisms, and related methods and systems, for producing liquid fuels from alkanes such as methane.

Abstract: An exercise device providing a fore and aft horizontal component of striding motion that is dynamically user-defined, while providing a vertical component of the motion that is maintained on a predetermined vertically reciprocating path in some embodiments. The exercise device guides the user's foot in a pseudo-elliptical stride path, while providing a dynamically variable stride length that allows the user to move with a natural stride length. The exercise device allows tall and short users to extend or curtail the stride length to match their natural stride lengths. The length of the reciprocating path is dynamically adjusted during the exercise operation without equipment adjustments by changes in the length of the stride input by the user at a pair of foot engagement pads disposed on laterally spaced apart foot support members.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: A method of making a core metal element for a medical guidewire comprising providing a wire of nickel titanium alloy having a length that includes a proximal portion having a first diameter and a distal portion having a second diameter. Applying cold work to the distal portion and not applying cold work to the proximal portion, thereby imparting to the distal portion a third diameter that is smaller than the second diameter; and then applying a reducing process to the wire whereby the proximal portion is reduced to have a fourth diameter that is less than the first diameter.

Abstract: Catheters and methods for removing material from (or “debulking”) a body lumen while imaging the region comprised of the material are provided. The catheters can be used in body lumens, including but not limited to intravascular lumens such as coronary or peripheral arteries. The catheters include housings or other structures to mount or protect an imaging transducer. Generally, debulking catheters include a proximal portion, a distal portion having an opening, a cutting element which may be exposed through the opening to contact material in a body lumen and an imaging transducer with associated circuitry and display. The catheter debulks a body lumen when it is moved while the cutting element is in contact with the material in the lumen and the region comprised of the material is imaged before, after, or during catheter movement.

Abstract: A thin-film coating applicator assembly is disclosed for coating substrates in outdoor applications.

Abstract: A system for tracking a moving target having up to six degrees of freedom and rapidly determining positions of the target, said system includes an easy to locate precision optical target fixed to the target. This system includes at least two cameras positioned so as to view the optical camera from different directions with each of the at least two cameras being adapted to record two dimensional images of the precision optical target defining precise target point. A computer processor is programmed to determine the target position of x, y and z and pitch, roll and yaw. In an embodiment, the system can be configured to utilize an iteration procedure whereby an approximate first-order solution is proposed and tested against the identified precise target points to determine residual errors which can be divided by the local derivatives with respect to each component of rotation and translation, to determine an iterative correction.

Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.

Abstract: A motion compensation system for tracking and compensating for patient motion during a medical imaging scan comprises an optical marker comprising an optically visible pattern and a mounting portion; a first optical detector positioned to digitally image the optically visible pattern along a first line of sight; a second optical detector positioned to digitally image the optically visible pattern along a second line of sight; a tracking engine configured to determine a pose of the object in six degrees of freedom by analyzing images from the first and second optical detectors; and a controller interface configured to generate tracking information based on the pose and to electronically transmit the tracking information to a scanner controller to enable compensation within a medical imaging scanner for object motion.

Abstract: An apparatus to enhance oil extraction from pores of a bowling ball includes a housing unit with an opening, a tank disposed within the opening and able to store a fluid, a rack disposed within the tank to secure the bowling ball in a stationary position and orient the ball such that at least one finger hole of the ball is positioned above an upper level of the stored fluid, a heating unit coupled to the tank to heat the stored fluid, and at least one ultrasonic transducer coupled to the tank. The at least one transducer directs sound waves through the heated fluid toward the secured bowling ball, thereby extracting oil from the bowling ball.

Abstract: A handle (16) is disclosed having an elongate portion (21) and a outrigger portion (26). The elongate portion has a longitudinal axis (24) which extends between two ends (22, 23) and is shaped to be grasped by an operator in use. The outrigger portion extends away from one end of the elongate portion and has a free end (27). The three ends (22, 23, 27) are each connected to the blower or other appliance by a corresponding anti-vibration coil spring (32, 33, 37) through which a corresponding bolt (42, 43, 47) passes. The outrigger portion prevents the elongate portion rotating about its longitudinal axis. In addition, the elongate portion can be grasped by a hand of an operator in either one of two positions. A first position substantially above the blower's centre of gravity provides a balanced grip whilst the blower is not operating. When the blower is operating, air is expelled from a tube having an exit generally coplanar with, or aligned with, the handle.

Abstract: An exercise device providing a fore and aft horizontal component of striding motion that is dynamically user-defined, while providing a vertical component of the motion that is maintained on a predetermined vertically reciprocating path in some embodiments. The exercise device guides the user's foot in a pseudo-elliptical stride path, while providing a dynamically variable stride length that allows the user to move with a natural stride length. The exercise device allows tall and short users to extend or curtail the stride length to match their natural stride lengths. The length of the reciprocating path is dynamically adjusted during the exercise operation without equipment adjustments by changes in the length of the stride input by the user at a pair of foot engagement pads disposed on laterally spaced apart foot support members.

Abstract: A duct can be configured to receive a denuding gas flow. A solid denuding surface that is connected to a drive system can be configured to move the solid denuding surface within the duct while the solid denuding surface is continuously concentrating one or more gas-phase species from the denuding gas flow on the denuding surface. Also, a denuding gas flow can be passed along a denuding surface to concentrate one or more gas phase species from the denuding gas flow onto the denuding surface with a diffusion denuding action. The denuding surface can be moved while continuing to concentrate the one or more gas phase species from the denuding gas flow onto the denuding surface.