Abstract: A damping arrangement comprises a drive member arranged to be driven for angular movement relative to a housing by a motor, and a damping device independent of the motor and operable to damp oscillating motion of the drive member relative to the housing.

Abstract: Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such viral inhibitor agents of Formula (I) in inhibiting and treating viral infections including orthopox and retroviral infections. Methods of synthesizing such agents are also provided herein.

Abstract: A laminate interconnect structure includes a core material and at least one additional layer adjacent the core material, a first electrically conductive via formed in the core material, and a second electrically conductive via formed in the core material, coaxial with the first electrically conductive via and separated from the first electrically conductive via by a non-conductive material.

Abstract: An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.

Abstract: The invention provides methods of treatment that prevent the onset of Mesial temporal lobe epilepsy (TLE) in a subject, or which reduce the severity of TLE in a subject, by administering a NKCC1 inhibitor to the subject after the subject has suffered from an insult known to precipitate TLE.

Abstract: A damping arrangement comprises a drive member arranged to be driven for angular movement relative to a housing by a motor, and a damping device independent of the motor and operable to damp oscillating motion of the drive member relative to the housing.

Abstract: The present invention provides for x-ray imaging and ultrasound imaging of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinatively employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis/biopsy of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head, as well as targeted ultrasound imaging of a selected portion of the region from which x-ray images are obtained. A user interface system facilitates various procedures including ultrasound guided needle biopsy procedures.

Abstract: Disclosed is a fuser member comprising a substrate, a layer thereover comprising a polymer or an elastomer, and, on the layer, a coating including mercapto- and amino-functionalities comprising from about 0.05 mole percent to about 1.00 mole percent mercapto groups and from about 0.0001 mole percent to about 0.06 mole percent amino groups, wherein the ratio of mercapto to amino mole percent values is at least 2. The layer preferably is a fluoropolymer or fluoroelastomer filled with a metal oxide (CuO, Al2O3, etc.).

Abstract: A filtration device having at least one filter packet and a retainer is described. The filter packet includes a membrane having at least a first opening therethrough. The filter packet further includes a retentate screen in fluid communication with the first side of the membrane and a filtrate screen in fluid communication with the second side. The retentate screen includes a permeable material and a seal around an outer perimeter of the permeable material. The permeable material has at least a feed port-defining zone in fluid communication with the first opening. The filtrate screen includes a permeable material and at least a feed port-defining zone in fluid communication with the first opening. The feed port-defining zone of the filtrate screen includes a seal around a perimeter thereof. The filtrate screen has a perimeter open to a filtrate collection area.

Abstract: A filtration cassette is described. The filtration cassette can include one or more filtrate channel spacers and one or more feed channel spacers. Each of the feed channel spacers and each of the filtrate channel spacers define an open interior volume bounded by an inner perimeter and include at least one feed port and at least one filtrate port. The filtrate channel spacers and the feed channel spacers are arranged such that the feed ports and the filtrate ports are positioned in respective alignment. The filtration cassette further includes one or more membranes disposed between the filtrate channel spacers and the feed channel spacers, and one or more retaining members at either end of the filtration cassette. A thin film of adhesive binds together the filtrate channel spacers, the feed channel spacers, and the membranes.

Abstract: An ESD protection circuit including the following: one or more inverters (I1, I2, I3), each of the one or more inverters having an input and an output; an RC network (11) having an output node (RCT), output node (RCT) connected with the input of at least one of said one or more inverters; a clamping device (N3) joined with the output of at least one of one or more inverters (I1, I2, I3); and a feedback device (NKP) in communication with clamping device (N3) and output node (RCT) of RC network (11). An RC network may include one or more resistors, and one or more decoupling capacitors. In one embodiment, feedback device (NKP) is an NFET and each of one or more inverters (I1, I2, I3) includes a PFET and NFET pair (P0/N0, P1/N1, P2/N2).

Abstract: The present invention provides a method and device for preventing cerebral embolization during endovascular procedures in the carotid arteries. The invention comprises a guide catheter and balloon, which may selectively occlude the common carotid artery, and further comprises a wire and balloon, which may selectively occlude the internal carotid artery. Occlusion of the common carotid artery will induce retrograde flow at the site, redirecting emboli to the external carotid artery. Occlusion of the internal carotid artery reduces the risk of emboli migrating to the brain, and allows clearance of the site by antegrade blood flow from the common carotid artery. Occlusion of both the common and internal carotid arteries induces a quiescent state at the site during the procedure. Control of blood flow by selective inflation and deflation of either or both balloons, in concert with the procedures, will reduce the risk of emboli migrating to the brain.

Abstract: Filtration devices that include filtration cassettes that feature a plurality of stacked subassemblies, wherein at least one of the subassemblies includes a porous membrane having a front side and a back side and a perimeter; and an overmolded frame that encapsulates the membrane around the perimeter of the front side and the back side of the membrane; wherein the overmolded frame forms at least one retentate port, at least one feed port, at least one filtrate port, and a flow channel proximate a perimeter of the frame; and an overmolded plastic jacket that penetrates the flow channels of the subassemblies to seal the stacked subassemblies; and methods for making the filtration device and cassettes.

Abstract: A flexible kink-resistant introducer sheath (10). The introducer sheath includes an inner liner (31), a coil (33) and an outer tube (33). The inner liner includes a passageway (30) extending longitudinally therethrough, where a catheter (50) can be advanced through the passageway. The coil (33) has a plurality of turns positioned longitudinally and compression fitted around the inner liner (31), where the turns have a predetermined spacing therebetween. The outer tube (20) is positioned longitudinally around the coil (33) and the inner liner (31), and is connected to the inner liner through the spaces between the turns. A diameter difference between the inner liner and the catheter is in a range of about 0.0005 to about 0.004 inch (0.013 to about 0.10 mm).

Abstract: An ESD protection circuit including the following: one or more inverters (I1, I2, I3), each of the one or more inverters having an input and an output; an RC network (11) having an output node (RCT), output node (RCT) connected with the input of at least one of said one or more inverters; a clamping device (N3) joined with the output of at least one of one or more inverters (I1, I2, I3); and a feedback device (NKP) in communication with clamping device (N3) and output node (RCT) of RC network (11). An ESD protection circuit according to claim 7, wherein said RC network includes one or more resistors, and one or more decoupling capacitors. In one embodiment, feedback device (NKP) is an NFET and each of one or more inverters (I1, I2, I3) includes a PFET and NFET pair (P0/N0, P1/N1, P2/N2).

Abstract: Disclosed is a fuser member comprising a substrate, a layer thereover comprising a polymer or an elastomer, and, on the layer, a coating including mercapto- and amino-functionalities comprising from about 0.05 mole percent to about 1.00 mole percent mercapto groups and from about 0.0001 mole percent to about 0.06 mole percent amino groups, wherein the ratio of mercapto to amino mole percent values is at least 2. The layer preferably is a fluoropolymer or fluoroelastomer filled with a metal oxide (CuO, Al2O3, etc.).

Abstract: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample.

Abstract: A Sequential Gray Code to Thermometer Code decoder circuit adapted for area efficient use at each pad of an integrated circuit chip for incrementally adjusting a digitally adjustable resistance for continuous or periodic adjustment of on-chip terminations. The sequential decoder for decoding a Gray code count to a T-bit Thermometer code count is constructed of a plurality (T) of cascaded decoder cells, each cell sensing the state of only one bit of the Gray code count. The decoder cells are cascaded to from decoding-latching stages each stage responsive to an individual one of single-bit changes between consecutive counts in the Gray code. Each stage contains a decoding-latching circuit adapted to detecting and latching the occurrence of one single-bit change in the Gray code.

Abstract: A Sequential Gray Code to Thermometer Code decoder circuit adapted for area efficient use at each pad of an integrated circuit chip for incrementally adjusting a digitally adjustable resistance for continuous or periodic adjustment of on-chip terminations. The sequential decoder for decoding a Gray code count to a T-bit Thermometer code count is constructed of a plurality (T) of cascaded decoder cells, each cell sensing the state of only one bit of the Gray code count. The decoder cells are cascaded to from decoding-latching stages each stage responsive to an individual one of single-bit changes between consecutive counts in the Gray code. Each stage contains a decoding-latching circuit adapted to detecting and latching the occurrence of one single-bit change in the Gray code.

Abstract: The present invention provides for x-ray imaging and ultrasound imaging of a body region of interest in a spatially correlatable manner. The resultant x-ray and ultrasound images may be combinatively employed to provide three-dimensional information regarding a location of interest within the body, and is particularly apt for use in the analysis/biopsy of potential lesions and suspicious masses in a female breast. The invention provides for direct body contact by an ultrasound imaging head, as well as targeted ultrasound imaging of a selected portion of the region from which xray images are obtained. A user interface system facilitates various procedures including ultrasound guided needle biopsy procedures.