Abstract: Intervertebral devices and systems, and methods of their use, are disclosed having configurations suitable for placement between two adjacent vertebrae, replacing the functionality of the disc therebetween. Intervertebral devices and systems contemplated herein are implantable devices intended for replacement of a vertebral disc, which may have deteriorated due to disease for example. The intervertebral devices and systems are configured to allow for ample placement of therapeutic agents therein, including bone growth enhancement material, which may lead to better fusion between adjacent vertebral bones. The intervertebral devices and systems are configured for use in minimally invasive procedures, if desired.

Abstract: This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders.

Abstract: A submersible well fluid system for operating submerged in a body of water may include an electric machine and a fluid end. The electric machine includes a rotor and a stator residing in a first housing at specified conditions. The fluid end may include an impeller and be coupled to the electric machine. The submersible well fluid system may also include an adjustable speed drive for the electric machine in the housing. The submersible well fluid system may also include a chemical distribution system for supplying treatment chemicals to the submersible well fluid system, a barrier fluid supply system for supplying a barrier fluid to the submersible well fluid system, and a pressure management system.

Abstract: A platform comprises one or more sensors that collect information about an environment as sensor data. A processor is in communication with the one or more sensors, wherein the processor executes enhancement engines that processes the sensor data into enhanced characterization data having a reduced amount of data compared to the sensor data. An output device electronically communicate the enhanced characterization data to a user, wherein the sensor and the output device comprise an assisted perception module worn by the user during an incident. A command interface device remote from the user to enable a person of authority to manage the incident and the user by receiving and displaying the enhanced characterization data, and by transmitting data and commands back to the assisted perception module.

Abstract: Dynamically configuring a storage system to facilitate independent scaling of resources, including: detecting a change to a topology of the storage system consisting of different sets of blades configured within one of a plurality of chassis; and reconfiguring the storage system to change an allocation of resources to one or more authorities responsive to detecting the change to the topology of the storage system.

Abstract: A process is provided for the preparation of lacing resistant, titanium dioxide particles for use in photodurable thin film production. Said process involves dewatering titanium dioxide particles that have been encapsulated with a layer of amorphous alumina in continuous fashion at temperatures in excess of 100° C.

Abstract: Provided herein are antibody construct molecules comprising (i) an Fc receptor binding site, (ii) an antigen-binding site and (iii) a spacer moiety located between (i) and (ii), wherein the spacer moiety serves to increase the distance between (i) and (ii) so as to reduce the agonistic activity of the molecule as compared to the antibody variant that lacks (iii). Disclosed are various antibodies that can be de-agonized by introduction of the spacer moiety. Of specific interest are agonistic check point targeting antibodies that are de-agonized by introduction of the spacer moiety.

Abstract: A pharmaceutical composition and a method for treating knee and/or hip pain in a patient non-responsive or intolerant to standard analgesic therapy are disclosed. A pharmaceutical composition and a method for reducing risk for developing an arthropathy in a subject receiving an anti-NGF antibody for treatment of knee and/or hip pain are disclosed. Also provided herein are methods for monitoring safety of a treatment of knee and/or hip pain involving administration of an anti-NGF antibody. In certain aspects, the subject has osteoarthritis of the knee and/or hip and the anti-NGF antibody is fasinumab.

Abstract: A method for dynamically configuring a storage system to facilitate independent scaling of resources is provided. The method includes detecting a change to a topology of the storage system consisting of different sets of blades configured within one of a plurality of chassis and reconfiguring the storage system to change an allocation of resources to one or more authorities responsive to detecting the change to the topology of the storage system.

Abstract: A method and system for water-priming carbon micropore filter media using negative pressure. The method includes placing dry filter elements in a polymer bag, applying a vacuum of no more than approximately 33 kPa above zero pressure, and heat-sealing the bag using a heat-set bar; submerging, by a consumer, the vacuum-sealed bag with its the filter elements in water; the filters in the vacuum sealed bag are at least partially submerged, puncturing the bag to form one or more small openings in the bag below the water line. Breeching the vacuum causes the water to flow through the openings into the bag and the filter(s) to equalize the pressure between the water and the previously vacuum environment of the plastic bag, causing the surrounding water to quickly flow into the micro-pores of the filter media, thereby priming the carbon filter for use in the gravity-fed water-purification system.

Abstract: Embodiments of the present invention are directed to methods, systems, and circuitry for reduced error in power consumption estimation for distinct circuitries. A non-limiting example includes distinct circuitry having an optimized power consumption definition. The distinct circuitry includes a substrate. The distinct circuitry includes an arrangement of interoperable hardware components disposed on the substrate having input pins defined according to a model described by a hardware description language operable to emulate toggle events of the interoperable hardware components defined by the model having a toggle event count based on combinations of the toggle events that correspond to predetermined power quantities. The toggle events define an aggregate toggle power consumption closer to an actual power consumption than an aggregate pin power consumption based on the input pins.

Abstract: A plurality of storage nodes is provided. Each of the plurality of storage nodes includes nonvolatile solid-state memory for user data storage. The plurality of storage nodes is configured to distribute the user data and metadata associated with the user data throughout the plurality of storage nodes such that the plurality of storage nodes maintain the ability to read the user data, using erasure coding, despite a loss of two of the plurality of storage nodes. The plurality of storage nodes is configured to initiate an action based on the redundant copies of the metadata, responsive to achieving a level of redundancy for the redundant copies of the metadata. A method for accessing user data in a plurality of storage nodes having nonvolatile solid-state memory is also provided.

Abstract: Dynamically forming a failure domain in a storage system that includes a plurality of blades, each blade mounted within one of a plurality of chassis, including: identifying, in dependence upon a failure domain formation policy, an available configuration for a failure domain that includes a first blade mounted within a first chassis and a second blade mounted within a second chassis, wherein each chassis is configured to support multiple types of blades; and creating the failure domain in accordance with the available configuration.

Abstract: This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders.

Abstract: A method and system for water-priming carbon micropore filter media using negative pressure. The method includes placing dry filter elements in a polymer bag, applying a vacuum of no more than approximately 33 kPa above zero pressure, and heat-sealing the bag using a heat-set bar; submerging, by a consumer, the vacuum-sealed bag with its the filter elements in water; the filters in the vacuum sealed bag are at least partially submerged, puncturing the bag to form one or more small openings in the bag below the water line. Breeching the vacuum causes the water to flow through the openings into the bag and the filter(s) to equalize the pressure between the water and the previously vacuum environment of the plastic bag, causing the surrounding water to quickly flow into the micro-pores of the filter media, thereby priming the carbon filter for use in the gravity-fed water-purification system.

Abstract: An online system presenting content items to a user generates a model that predicts a latent metric describing user actions that occur at least a reasonable amount of time after presentation of content items. To determine the latent metric, the online system retrieves one or more models predicting likelihoods of the user performing various interactions when presented with the content items and determines weights associated with different retrieved models. Combining the weighted retrieved models generates a model for determining the latent metric. As the retrieved models are based on data accessible to the online system in less than the reasonable amount of time after presenting content items, weighing the retrieved models allows the online system to predict the latent metric describing user actions occurring after content items are presented. When selecting content items for the user, the online system accounts for the latent metric determined by the generated model.

Abstract: A method of treating a reservoir penetrated by at least one well involves placing a consolidated solids pack into a permeable zone of rock in the reservoir. The consolidated solids pack has a reduced permeability to water and a reduced mobility in the permeable zone. For example, when placed in the permeable zone in connection with a water flooding operation, the consolidated solids pack diverts the injectant from the permeable zone to other less permeable zones of the reservoir that contain oil.

Abstract: A non-volatile solid-state storage is provided. The non-volatile solid state storage includes a non-volatile random access memory (NVRAM) addressable by a processor external to the non-volatile solid state storage. The NVRAM is configured to store user data and metadata relating to the user data. The non-volatile solid state storage includes a flash memory addressable by the processor. The flash memory is configured to store the user data responsive to the processor directing transfer of the user data from the NVRAM to the flash memory.

Abstract: A self-learning translation-engine brokering system characterizes a set of language-translation engines by associating each engine with values of a set of engine parameters. The system receives a request to translate text or speech input, along with a set of weightings that identify the relative importance of each engine parameter to the translation requester. The system formats the input into a quantifiable engine-agnostic form and performs an optimization procedure that finds the best fit between the source's weightings and the sets of engine parameters. The system directs the input to the best-fitting translation engine, receives the translated output from the selected engine, directs the output to the translation requester, and then determines how well the translated output meets user expectations. This feedback used to update the best-fitting engine's parametric values and to train the system to make more accurate selections in the future.

Abstract: A method for testing a circuit includes receiving, by a noise injection circuit, an input signal and generating a noise pulse. Generating the noise pulse includes computing an input resistor pulse, and computing an output resistor pulse. Generating the noise pulse further includes short-circuiting an output resistor substantially simultaneously with opening an input resistor. The method for testing the circuit includes modifying, by the noise injection circuit, the input signal using the noise pulse.