Abstract: Systems and methods are described herein for monitoring a gas source for a gas analyte. The gas source can be monitored for release of the gas analyte, for example, during a given gas source state. A sensor signal can be generated characterizing an amount of the gas analyte being released by the gas source. The gas sensor signal can be evaluated relative to a threshold. An alert signal can be generated based on a result of the comparison to provide a warning that unwanted and/or hazardous amounts of gas is being released by the gas source.

Abstract: An affordable family of threaded pipe connections is disclosed, that have desired strengths and service torques, for a wide range of sizes and services.

Abstract: A turbine blade includes a labyrinth of internal channels for the circulation of coolant received through an inlet formed in a terminal portion of the blade root and leading to a duct- defined wall. A first passage intersects the duct and extends through the blade towards a tip. An end of the first passage is arranged to capture incoming coolant flow. A second passage intersects the duct at a position downstream of the first passage intersection. The duct and/or the passage intersections are configured to create a pressure drop in the duct in the direction from the inlet to the second passage intersection. In an axial direction, a duct wall terminates at a position between the inlet and the second passage intersection to balance the pressure of coolant in the duct with the pressure of coolant in a leakage path thereby reducing the mass flow of coolant entering the leakage path.

Abstract: A turbine stage assembly includes a disc carrying a cascade of blades and an annular seal-plate that is secured to the disc by a first connection. One or more of the blades include a root portion configured to be received in a complementarily shaped radially extending slot in the disc such that a face of the root portion faces the plate. A terminal portion of the root portion is cut away adjacent the face to present an open space between a radially inner wall of the slot and a wall of the cutaway root portion. A first part of a second connector extends radially inwardly from the wall of the cutaway root portion. The first part of the second connector is configured to engage with a complementing second part of the second connector provided on the seal-plate.

Abstract: Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2—; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkylyl). and the alkyl or cycloalkylyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description.

Abstract: A turbine blade has a trailing end and a leading end and a tip. A gutter is formed in the tip and extends to an exit defined in a region of the trailing end of the blade. The gutter is defined at least in part by a floor, and the floor defines a decreased depth in a region proximal to the exit than in a region distal to the exit.

Abstract: Devices systems and methods are provided for providing a deterministic remote interface unit (RIU) based on a finite state machine. The RIU emulator uses a sequence controller that is configured to receive a synchronization input and to execute a fixed list of unconditional commands in an invariable order of execution based solely upon the synchronization input. The RIU emulator also uses pre-defined or pre-certified data structures that are specific to one or more interface devices to successfully execute the at least one unconditional command of the plurality when encountered in the invariable order. As such, peripheral devices may be added, removed or updated without recertification by merely inserting pre-certified data structures into memory or deleting them.

Abstract: Described are lantibiotic-based compounds, pharmaceutical compositions comprising the same and use of the compounds and said compositions, for the treatment of microbial infection, for example Clostridium difficile or Micrococcus luteus infection. The lantibiotic-based compounds have antimicrobial activity and in comparison to one or more of actagardine, actagardine B, deoxyactagardine B and deoxyactagardine have retained activity or improved activity.

Abstract: Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2—; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkyl). and the alkyl or cycloalkyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description.

Abstract: Soybean plants comprising event SYHT04R, methods of detecting and using the same, and soybean plants comprising a heterologous insert at the same site as SYHT04R.

Abstract: A method of thermally treating tissue during a surgical procedure where a surgical access device, including a body member having walls with at least one conduit therein, is inserted into the patient. A chilled fluid is circulated through the at least one conduit such that the tissue that is located proximate the body member is cooled. Alternatively, the body member may be constructed from a highly thermally conductive material such that heat energy is transmitted through the body from the tissue located proximate the body member and into a heat sink. The surgical device may include a first or second blade portions constructed from an inner and an outer shell having walls. Ribs located on the inner shell sealingly coupled to the inner wall of the outer shell to create the at least one conduit within the walls of the blade portion.

Abstract: A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.

Abstract: A hinge set (and associated methodology and resultant hung doors or windows) where the leaf of each hinge sleeved component is, or is to be, leafwise received in, and is, or to be, screwed into, a different cavity, yet allowing aligned sleeve meshing for pin insertion. Its use allows the leaf to be largely concealed even when the doors or windows are open.

Abstract: Characterization of the biosynthetic gene cluster for the lantibiotic antibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterized biosynthetic gene clusters, is described.

Abstract: Described are lantibiotic-based compounds, pharmaceutical compositions comprising the same and use of the compounds and said compositions, for the treatment of microbial infection, for example Clostridium difficile or Micrococcus luteus infection. The lantibiotic-based compounds have antimicrobial activity and in comparison to one or more of actagardine, actagardine B, deoxyactagardine B and deoxyactagardine have retained activity or improved activity.

Abstract: Adjustment of stresses within a threaded connection having radial thread interference is taught by forming the box and pin threads on different axial pitches before assembly, so as to result in a preferred stress pattern after assembly. Also taught, is how to shape thread forms so as to avoid galling while connecting or disconnecting the box and pin.

Abstract: A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.

Abstract: A flat-hose assembly has a proximal end and a distal end adapted for use with a negative pressure wound drainage system. The flat-hose assembly comprises a top layer, a bottom layer, and a filter layer. The bottom layer forms an opening at the distal end of the flat-hose assembly to allow exudates of a wound to flow into the flat-hose assembly. The filter layer is disposed between the top layer and the bottom layer. The top and bottom layer form a seal area along a periphery of the top layer and the bottom layer to seal the filter layer therebetween.

Abstract: This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterised biosynthetic gene clusters.

Abstract: Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine are described.