Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.

Abstract: A vacuum cleaner handle mount assembly securable to a vacuum cleaner having a handle that can be pivoted from a storage position to an in-use position is disclosed. The vacuum cleaner handle mount assembly has a housing with a first and second channel, a handle with a first and second leg for respectively connecting to the first and second channel of the housing, a first and second locking mechanism for preventing the handle from pivoting during use, and a first and second nest respectively disposed in a side of the first and second channel for holding the first and second locking mechanisms respectively. The first and second locking mechanisms are rotatable from an in-use position extending across the respective first and second channels above the respective first and second legs and a storage position wherein the first and second locking mechanisms are located within the first and second nest respectively.

Abstract: A hand tool may include a head section defining a first grip portion, a handle section and a second grip portion. The head section includes a top jaw and a bottom jaw defining the first grip portion. The handle section includes a top handle and a bottom handle. The top jaw and the bottom handle forming a first unitary piece, and the bottom jaw and the top handle forming a second unitary piece. The first and second unitary pieces are joined at a pivot point. The second grip portion includes a top grip portion provided at the top handle and a bottom grip portion provided at the bottom handle. The top and bottom grip portions substantially face each other. The first grip portion is made of a metallic material and the second grip portion is made of a non-metallic material.

Abstract: A working machine comprising a ground engaging structure and an undercarriage connected to the ground engaging structure. A superstructure is rotatably mounted to the undercarriage so as to be rotatable relative to the undercarriage about a first generally upright axis, an operator's cab is rotatably mounted on the superstructure so as to be rotatable relative to the superstructure about a second generally upright axis, and a working arm is rotatably mounted to the superstructure so as to be moveable up and down about a generally horizontal axis. A drive arrangement is provided for driving the ground engaging structure to propel the working machine. The drive arrangement includes an engine and transmission that are housed within the undercarriage, and a majority of the engine is positioned below a level coincident with a lower extent of the superstructure.

Abstract: A base assembly for a working machine. The base assembly comprising a ground engaging structure, an undercarriage connected to the ground engaging structure, and a connector for connecting the undercarriage to a superstructure that mounts a working arm. A drive arrangement is provided for moving the ground engaging structure to propel, in use, the base assembly and a connected superstructure. The drive arrangement includes a prime mover and a transmission and the drive arrangement is housed within the undercarriage. An electronic control unit (ECU) is provided for controlling the drive arrangement and/or the ground engaging structure.

Abstract: A working machine comprising: a ground engaging structure with a first and second axle, each mounting two wheels; a body supported on the ground engaging structure, a working arm mounted to the body; and a drive arrangement for moving the ground engaging structure to propel the working machine, the drive arrangement including a prime mover and transmission. The transmission comprises a hydraulic pump driven by the prime mover, a first high speed hydraulic motor to drive the first axle to permit the working machine to be driven at relatively high speeds in a first two-wheel drive operating mode, and a second low speed motor to be supplied with hydraulic fluid from the hydraulic pump to drive the second axle at relatively low speeds and configured to be driven in conjunction with the first motor in a second four-wheel drive operating mode.

Abstract: An insert for a water sports board, wherein the insert includes a pre-preg flange extending outwardly from an injection molded central housing to provide enhance structural properties of the insert, as well as enhanced intermediate bonding between the injection molded central housing and a surface polymer. The pre-preg flange further improves the strength to weight ratio when compared to conventional inserts.

Abstract: A structure, such as a fin or water sports board, including a core having opposed first and second core outer surfaces. The structure further includes first and second fiber sheets, wherein the first fiber sheet extends along the first core outer surface and the second fiber sheet extends along the second core outer surface. A thermoplastic material impregnates the first fiber sheet and the second fiber sheet and bonds the first fiber sheet and the second fiber sheet to the core. The thermoplastic material defines an outer surface of the structure.

Abstract: A method of forming a fin configured for use with a water sports board. The method includes providing a mold having a mold cavity and first and second insert pre-preg sheets each including structural strands respectively bonded by first and second resin materials. The method further includes placing the insert pre-preg sheets within the mold cavity. The method further includes injecting a third resin material under pressure into the mold cavity between the first insert pre-preg sheet and the second insert pre-preg sheet to urge the first insert pre-preg sheet and the second insert pre-preg sheet away from each other and towards respective ones of the pair of mold cavity faces, and dispose the third resin material between the first insert pre-preg sheet and the second insert pre-preg sheet to space at least a portion of the first insert pre-preg sheet from the second insert pre-preg sheet.

Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.

Abstract: Architecture that provides enhanced tag telemetry in a microblogging communications infrastructure. The architecture provides efficient discovery and tracking of topics that are of interest to a specific user by enabling users to follow (track) hash tags (#tag) and to receive and view all messages tagged with the hash tag appear in the user's personal feed. Each hash tag has a persisted tag page that aggregates all the associated activity, and includes a list that includes, but is not limited to, the tag followers, the most frequent user (uses the tag the most often in a specific time frame), a description, related tags, for example. The user can receive all the updates in the user's personal feed, and see an aggregation of all the messages and conversations associated with the tag in single place. The user can also mute the tag to prevent the receiving of tag information.

Abstract: A fin for a water sports board including leading and trailing edges, and a base extending therebetween along a longitudinal base axis. A fin axis extends generally perpendicular to the longitudinal base axis, both axes residing within a longitudinal plane. First and second opposed side faces are formed on generally opposed sides of the longitudinal plane. First and second insert pre-preg sheets formed of structural strands bonded by a resin material are disposed adjacent respective ones of the first and second side faces on generally opposed sides of the longitudinal plane. An injection molded resin material is disposed between the first and second insert pre-preg sheets. A core is positioned between the first and second insert pre-preg sheets and is of a density less than the injection molded resin material.

Abstract: An expandable trial can include an inferior portion, a superior portion, and a middle expanding portion as well as load cells for monitoring the load on the trial. The trial may also include recesses on its lateral sides to provide spacing to accommodate a disc removal tool so tissue can be cleared monitoring load. In addition, neural foramen spacing can be monitoring to provide information about how much neural release has been achieved as the disc is cleaned and the spine is positioned and repositioned.

Abstract: Architecture that provides enhanced tag telemetry in a microblogging communications infrastructure. The architecture provides efficient discovery and tracking of topics that are of interest to a specific user by enabling users to follow (track) hash tags (#tag) and to receive and view all messages tagged with the hash tag appear in the user's personal feed. Each hash tag has a persisted tag page that aggregates all the associated activity, and includes a list that includes, but is not limited to, the tag followers, the most frequent user (uses the tag the most often in a specific time frame), a description, related tags, for example. The user can receive all the updates in the user's personal feed, and see an aggregation of all the messages and conversations associated with the tag in single place. The user can also mute the tag to prevent the receiving of tag information.

Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.