Abstract: The present invention relates to an assembly apparatus for assembling components of spacecraft in space. The assembly apparatus includes: a core platform; and a mobile platform including an end effector configured to perform an assembly or manufacturing task. The mobile platform is connected to the core platform by a tether. The core platform includes a body and a coupling element connected to and extendable from the body such that the coupling element may be spaced from the body of the core platform. The tether connects the mobile platform to the body via the coupling element. The assembly apparatus further includes an actuator configured to vary the length of the tether extending between the coupling element and the mobile platform to control the position of the mobile platform relative to the body of the core platform.

Abstract: A method for harmful algal bloom (HAB) mitigation is provided. The method may include preparing a HAB mitigation substance comprising a curcuminiod substance, and applying the HAB mitigation substance to a HAB to destroy algal cells within the HAB and prevent or inhibit release of toxins from the algal cells.

Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amount of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.

Abstract: In an aspect the current disclosure may describe a electric charging station for an electric vehicle. The electric charging station may include a charging cable, wherein the charging cable is configured to carry electricity and an energy source, wherein the energy source is electrically connected to the charging cable. The charging station may further include a temperature sensor, wherein the temperature sensor is configured to generate temperature datum and a computing device. A computing device may be communicatively connected to the plurality of temperature regulating elements and the temperature sensor. The computing device may further be configured to receive the battery datum and regulate battery temperature and cabin temperature using the plurality of temperature regulating elements as a function of the temperature datum.

Abstract: Several embodiments of the present invention are generally directed to medical visualization systems that comprise combinations of disposable and reusable components, such as catheters, functional handles, hubs, optical devices, etc. Other embodiments of the present invention are generally directed to features and aspects of an in-vivo visualization system that comprises an endoscope having a working channel through which a catheter having viewing capabilities is routed. the catheter may obtain viewing capabilities by being constructed as a vision catheter or by having a fiberscope or other viewing device selectively routed through one of its channels. The catheter is preferably of the steerable type so that the distal end of the catheter may be steered from its proximal end as it is advanced with the body. A suitable use for the in-vivo visualization system includes but is not limited to diagnosis and/or treatment of the duodenum, and particularly the biliary tree.

Abstract: The present disclosure provides anti-bed bug monoclonal antibodies and antigen-binding fragments thereof as well as compositions and kits comprising the same. The present disclosure also provides methods of making monoclonal antibodies and antigen-binding fragments thereof and methods of using the same to detect bed bugs.

Abstract: A dietary supplement and methods for the manufacture and administration of the same are disclosed for the treatment and/or prevention of digestive disorders and immune-related disorders. The dietary supplement of the present invention is orally administrable, and may be compounded either in a solid form (including bars, wafers or pills), a paste form, a granular form, a powder form, or a liquid form. The ingredients of the dietary supplement of the present invention when combined provide a synergistic efficacy which greatly exceeds the sum of the efficacies of the individual ingredients, making the dietary supplement highly effective in the treatment and/or prevention of digestive disorders and immune-related disorders. The dietary supplement of the present invention is compounded so as to increase the impermeability of the gut lining as well as to balance the bacteria components of the microbiota, thereby minimized systemic inflammation, the cause of most chronic diseases.

Abstract: A tyre T for adaptively adjusting to the tyre's rolling conditions, the tyre T comprising first and second side walls (1, 2) with a contact wall (3) extending therebetween and a heater 7 for heating one or more of the first side wall (1), second side wall (2) and contact wall (3), wherein plural chambers (4, 5, 6) are defined within the tyre T, at least one of the plural chambers (4, 6) being selectively inflatable for altering the external shape of the first side wall (1), second side wall (2) and/or contact wall (3).

Abstract: An apparatus for promoting circulation through a subcutaneous lymph vascular network may comprise a first manifold layer, a second manifold layer coupled to the first manifold layer, and a cover layer coupled to the second manifold layer. The first manifold may have a first stiffness, and the second manifold may have a second stiffness greater than the first stiffness. In some embodiments, the apparatus may additionally have a fluid interface configured to fluidly couple at least one of the first manifold layer and the second manifold layer to a fluid conductor through the cover layer. The fluid conductor may be coupled to or configured to be coupled to a source of negative pressure.

Abstract: A reduced-pressure system for treating a tissue site on a patient includes a distribution manifold that adheres to a tissue site to allow retention without external support. The distribution manifold includes a porous member and a tissue-fixation element. The tissue-fixation element maintains the porous member substantially adjacent to the tissue site while a sealing member is applied. In one instance, the tissue-fixation element is a soluble adhesive that partially covers either the tissue-facing side of the porous member or a tissue-facing side of a fluid-permeable substrate layer that is on the tissue-facing side of the porous member. Other systems, distributions manifolds, and methods are presented.

Abstract: Connection pads for coupling fluid-instillation and negative pressure wound therapy (NPWT) apparatuses to wound dressing, and methods and wound dressings for breaching a drape after coupling a wound dressing to a fluid-instillation and/or NPWT apparatus.

Abstract: System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display.

Abstract: A system including an implant and a tool for inserting and expanding the medical implant and locking the implant in place is disclosed. The medical implant may include an expandable body defined by a superior endplate and an inferior endplate that are hingedly coupled and may be expanded and lordosed. The implant may include a wedge disposed between the superior and inferior endplates that is configured to slide across a channel on inferior endplate and along an inclined groove on superior endplate. In at least some embodiments, an expansion screw is operative coupled to the threaded portion of the wedge that when expansion screw is rotated, the wedge is translated thereby expanding the implant.

Abstract: System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display.

Abstract: Composition comprising recombinant Gplb? receptor protein Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ib? that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.

Abstract: Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include an outer sheath, an intermediate sheath, and an inner sheath. One or more of the outer sheath, the intermediate sheath, and the inner sheath may be reinforced with a braided structure to prevent elongation and ovalization of the sheaths. The braided structure may include one or more yarn members imbedded in a material and formed from a plurality of twisted singles. The twisted singles may be formed from an aromatic polyamide material.

Abstract: A composition that binds to an anti-CD38 antibody includes a specific sequence of a recombinant soluble form of an extracellular domain of CD38 and/or a fragment thereof that interferes with binding activity of the anti-CD38 antibody. The composition can be included in a kit for bio-monitoring research and diagnostic assays. The composition can be used to neutralize an anti-CD38 antibody in a sample and/or to select a suitable red blood cell unit for a patient treated with anti-CD38 antibodies.