Abstract: In some examples, a dressing filler for treating a tissue site may include a plurality of filler elements and a tissue interface layer. Each of the filler elements may include a first surface and a second surface opposite the first surface and separated from the first surface by a thickness. The tissue interface layer may include a first side configured to be positioned facing the tissue site and a second side positioned opposite the first side. The first surface of each of the filler elements may be coupled to the second side of the tissue interface layer. Also provided are other apparatuses, dressings, systems, and methods suitable for treating a tissue site.

Abstract: Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Abstract: Implantable devices—such as stents and rings—that comprise markers for tracking their deployment in a body lumen are disclosed. The markers may be used to monitor progress of expansion of the implantable device, potential migration of the implantable device, and diameters of the body lumen. Markers may be deployed in the body lumen separately from another implantable device to assist tracking of migration of the implantable device. Markers may be placed circumferentially around a wall of a body lumen to track growth of an aneurysm or a stricture.

Abstract: A vascular stent deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include a self-expanding stent constrained by a rupturable sleeve. The self-expanding stent is disposed around an expandable member configured to partially expand to rupture the sleeve allowing the self-expanding stent to deploy. The expandable member may also be configured to aid in proximal displacement of the self-expanding stent as the delivery catheter assembly is manipulated to deploy the self-expanding stent.

Abstract: A reduced-pressure system for treating a tissue site on a patient includes a distribution manifold that adheres to a tissue site to allow retention without external support. The distribution manifold includes a porous member and a tissue-fixation element. The tissue-fixation element maintains the porous member substantially adjacent to the tissue site while a sealing member is applied. In one instance, the tissue-fixation element is a soluble adhesive that partially covers either the tissue-facing side of the porous member or a tissue-facing side of a fluid-permeable substrate layer that is on the tissue-facing side of the porous member. Other systems, distributions manifolds, and methods are presented.

Abstract: Provided herein is a system and method for monitoring, troubleshooting, and providing predictive maintenance to pumps systems. The methods provided herein can utilize and/or interpret physical phenomena of pump systems and components thereof. The physical phenomena may include, but is not limited to, vibration, temperature, sound, or similar characteristics. Further, a cloud-based system can collect data from autonomously operated systems, to provide visualizations of collected data via a user interface, and analyze the collected data with various models to predict maintenance, determine optimizations, and facilitate troubleshooting of the systems.

Abstract: A negative pressure wound treatment (NPWT) system including a NWPT therapy unit and a wound dressing configured to overlay a wound bed. The NPWT system includes a first length of tubing comprising a first end and a second end, the first end of the first length of tubing coupled to the NWPT therapy unit and the second end of the first length of tubing having a first coupling half, as well as a second length of tubing having a first end and second end, the first end of the second length of tubing coupled to the wound dressing and the second end of the second length of tubing having a second coupling half. The NPWT system includes an inline filter comprising a sintered polymer and a superabsorbent material, and an inline coupling, wherein the inline coupling is configured to operably couple and de-couple the NPWT therapy unit and wound dressing.

Abstract: Disclosed embodiments relate to devices and systems for providing negative-pressure therapy, instillation, and/or pressure-sensing at a tissue site, and to methods of manufacturing such devices and systems. In some embodiments, a fluid bridge may comprise a first layer of foam with a plurality of supports extending from at least an inner surface, and a second layer. The first and second layers may be coupled together around the perimeter to form one or more enclosed fluid pathways, for example extending from a port to an aperture. In some embodiments, at least the first layer may be formed of closed-cell foam.

Abstract: A treatment system for applying negative pressure therapy and fluid instillation treatment to a tissue site, particularly an abdominal tissue site, is disclosed. In some embodiments, the treatment system may include a dressing member, a plurality of fluid removal pathways, a fluid instillation matrix, a drape, a negative-pressure source, and a fluid instillation source. Instillation fluid may be delivered from the fluid instillation source to the tissue site through the fluid instillation matrix, and negative pressure may be communicated and fluid withdrawn from the tissue site through the plurality of fluid removal pathways.

Abstract: Medical appliances, such as stent grafts, may be formed of a cover and a scaffolding. The cover is composed of multiple layers of polymeric materials. A luminal layer is formed of rotational spun fibers of polytetrafluoroethylene. An abluminal layer is formed of expanded polytetrafluoroethylene. The scaffolding is disposed between the luminal layer and the abluminal layer. A cell impermeable layer is also disposed between the luminal layer and the abluminal layer. The cell impermeable layer is formed of an elastomeric material. The cell impermeable layer is impervious to cell migration across the layer when the stent graft is in a nominal state and in an expanded state. The stent graft is free of pleats or wrinkles when the stent graft is in the nominal state and in the expanded state.

Abstract: An interbody system including an implant and a tool for inserting and expanding the medical implant and locking the implant in place is disclosed. The medical implant may include an expandable body defined by a superior endplate and an inferior endplate that are hingedly coupled and may be expanded and lordosed. The superior and inferior endplate may include gripping protrusions that mate and/or directly engage with recessed jaws of disclosed surgical tool. The surgical tool may include a vertically movable jaw to expand and contract the implant when engaged with the gripping protrusions of the implant. The surgical tool may also include a drive portion that engages the drive feature of the lock screw with the drive end of the surgical tool lock the implant while in an expanded position.

Abstract: Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ib? that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.

Abstract: A unibody implant movable between an expanded position and a contracted position is disclosed. The unibody implant may include a unitary expandable body defined by an inferior portion and a superior portion that are connected together. In various embodiments, a set screw may be rotatably supported by the body and configured to move a plug having a first inclined surface facing the distal side. In various embodiments, the set screw may be movable in the longitudinal direction towards the distal side upon rotation of the set screw along the rotation axis, for example. In various embodiments, movement of the set screw urges the plug against the superior portion thereby expanding a vertical distance between the superior and inferior sides of the body. In some embodiments, the plug may include a stabilizing element configured to transfer compressive forces between the superior portion and inferior portion.

Abstract: A mobile treatment system is provided for treating contaminates in water, particularly during emergency situations such as natural disasters and planned attacks. The mobile treatment system includes a mobile framework; one or more treatment modules mounted on the mobile framework; a piping system in fluid communication with the one or more treatment modules, said piping system comprising one or more pumps configured to convey water to and from the one or more treatment modules; and at least one power source to provide power to the one or more pumps and one or more treatment modules. The treatment modules may include pre-filtration, chlorination treatment that generates chlorine by electrolysis, activated carbon treatment, and treatment using a disinfecting, silver coated composite material.

Abstract: A composition that binds to an anti-CD38 antibody includes a specific sequence of a recombinant soluble form of an extracellular domain of CD38 and/or a fragment thereof that interferes with binding activity of the anti-CD38 antibody. The composition can be included in a kit for bio-monitoring research and diagnostic assays. The composition can be used to neutralize an anti-CD38 antibody in a sample and/or to select a suitable red blood cell unit for a patient treated with anti-CD38 antibodies.

Abstract: Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Abstract: One or more techniques and/or systems are disclosed for mitigating fluid loss or leakage from a fluid pump with a rotating shaft driving a pumping mechanism. A packing gland component can have an internal seal formed by two dynamic O-rings that allows for use of lubricants at high pressures, as well as an outer seal for greater prevention of fluid loss. Further, the packing gland component can be a retrofit for existing packing gland components to provide for greater life and efficiency as compared to the existing packing gland components. Additionally, in some implementations, a sleeve may be fixedly attached to the rotating shaft between the packing gland and the shaft to provide a wear point for the packing gland.

Abstract: Bifurcated endovascular prostheses used to treat diseased blood vessels, such as arteries, are disclosed. In some embodiments, the bifurcated endovascular prosthesis is configured to be implanted within the diseased blood vessels adjacent a diseased section. The bifurcated endovascular prosthesis includes a primary stent graft and a secondary stent graft. The primary stent graft includes a pocket or sleeve disposed within a bore. A proximal portion of the secondary stent graft is disposed within the pocket or sleeve. Blood flow through the bifurcated endovascular prosthesis is divided into two flows, a first flow through the primary stent graft and a second flow through the secondary stent graft.

Abstract: Bifurcated endovascular prostheses used to treat diseased blood vessels, such as arteries, are disclosed. In some embodiments, the bifurcated endovascular prosthesis is configured to be implanted within the diseased blood vessels adjacent a diseased section. The bifurcated endovascular prosthesis includes a primary stent graft and a secondary stent graft. The primary stent graft includes a pocket or sleeve disposed within a bore. A proximal portion of the secondary stent graft is disposed within the pocket or sleeve. Blood flow through the bifurcated endovascular prosthesis is divided into two flows, a first flow through the primary stent graft and a second flow through the secondary stent graft.

Abstract: Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.