Abstract: Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample. A method for processing biomolecules may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (RNA) molecule) and barcoding the probe-nucleic acid molecule complex or derivatives thereof. Such a method can comprise performing a nucleic acid reaction, e.g., extension, denaturation, and amplification. A method for processing a sample may comprise hybridizing probes to (i) target regions of a nucleic acid molecule (e.g., RNA molecule) and (ii) a reporter oligonucleotide of a feature binding group, and barcoding the probe-associated molecules. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well.

Abstract: A method of automatically detecting adhesive wash-off includes: capturing, by a vision system, before-images of adhesive-covered areas on an assembly bonded by an adhesive before a process; capturing, by the vision system, after-images of the adhesive-covered areas on the assembly after the process; and determining, by a data processing module, an occurrence of the adhesive wash-off based on a comparison between the before-images and the after-images. The method further includes automatically determining a root cause of the adhesive wash-off when a number of occurrences of the adhesive wash-off exceeds a threshold.

Abstract: Systems and methods for projecting one or more trends in electronic data and generating enhanced data. A system includes a data forecasting system is in electronic communication with one or more electronic data sources via an electronic network. The data forecasting system is configured to: monitor the electronic data source(s) for data that meet one or more predetermined criteria; obtain at least a portion of the monitored data from electronic data source(s) based on the predetermined criteria; create a data set from the obtained data; derive one or more data values associated with the data set over a predetermined period according to a forward-looking term methodology; and utilize the data set and the derived value(s) over the predetermined period to derive at least one data forecast metric associated with the data set.

Abstract: A system for applying material to a part includes an application nozzle attached to a distal end of a robotic arm, a sensor coupled to the distal end of the robotic arm, an actuator mechanically coupled to the application nozzle, and a controller in communication with the actuator and configured to receive data from the sensor and detect a feature of the substrate. The robotic arm is configured to hold the application nozzle in a fixed position and/or traverse a predefined path such that the application nozzle traverses a predefined global bead path across and spaced apart from a substrate. The controller is configured to direct the actuator to move the application nozzle independent of the distal end of the robotic arm such that a bead of material flowing out of the application nozzle is applied to the substrate along a feature-relative bead path.

Abstract: A configuration helper system (CHS) is described that simplifies the task of generating configuration information for a customer premises equipment (CPE) in a customer's on-premise network to enable the CPE to communicate with the customer's cloud network over a particular communication channel. The CHS is configured to generate configuration information that is customized for the particular CPE and communication channel. Given information about the CPE and the communication channel, the CHS automatically identifies a particular set of configuration parameters to be included in the customized configuration information and determines values for the set of parameters, where some of the values may be provided by the customer. A particular CPE-specific format is determined for the configuration information.

Abstract: A system and method for isolating electronic data and generating enhanced data. A data subscription unit receives data having plural data formats from data source devices. The data may be received pre-filtered or filtered by the data subscription unit. A modeling unit may receive the filtered data from the storage databases, may determine eligibility of the stored data based on eligibility criteria, sort the eligible data based on at least one sorting parameter, adjust and/or normalize the eligible data based on at least one adjustment parameter and/or an aggregate value for a data attribute, generate data metrics over a defined set of time periods based on the eligible data, generate further data metrics based on the data metrics, and derive specified values from these metrics. A data distribution device may transmit or make available the data metrics, further data metrics and values to remote devices.

Abstract: Systems and methods for projecting one or more trends in electronic data and generating enhanced data. A system includes a data forecasting system is in electronic communication with one or more electronic data sources via an electronic network. The data forecasting system is configured to: monitor the electronic data source(s) for data that meet one or more predetermined criteria; obtain at least a portion of the monitored data from electronic data source(s) based on the predetermined criteria; create a data set from the obtained data; derive one or more data values associated with the data set over a predetermined period according to a forward-looking term methodology; and utilize the data set and the derived value(s) over the predetermined period to derive at least one data forecast metric associated with the data set.

Abstract: A method of manufacturing a metal component includes performing a test stamping process on a test sheet metal blank, generating a strain map of the test sheet metal blank for the test stamping process, generating a lubrication program based on the strain map, applying lubrication to the sheet metal according to the lubrication program, and stamping the sheet metal to form the metal component. The lubrication program is configured to control a lubrication system to apply lubrication to sheet metal in a non-uniform distribution across the sheet metal. The non-uniform distribution correlates to the strain map.

Abstract: A welded structural assembly and method, in one form, includes an upper substrate, a lower substrate adjacent the upper substrate, a fastener, and a sealing member. The fastener includes a shank portion, a first head portion, and a second head portion. The shank portion extends through the upper substrate and into the lower substrate. The shank is welded to the lower substrate. The first head portion has an outer periphery and an underside. The second head portion is frangibly coupled to the first head portion. The sealing member is disposed under the first head portion between the upper substrate and the first head portion. The sealing member contacts the underside and extends beyond the outer periphery such that the sealing member extends radially outward beyond all points of the first head portion.

Abstract: A system and method for isolating electronic data and generating enhanced data. A data subscription unit receives data having plural data formats from data source devices. The data may be received pre-filtered or filtered by the data subscription unit. A modeling unit may receive the filtered data from the storage databases, may determine eligibility of the stored data based on eligibility criteria, sort the eligible data based on at least one sorting parameter, adjust and/or normalize the eligible data based on at least one adjustment parameter and/or an aggregate value for a data attribute, generate data metrics over a defined set of time periods based on the eligible data, generate further data metrics based on the data metrics, and derive specified values from these metrics. A data distribution device may transmit or make available the data metrics, further data metrics and values to remote devices.

Abstract: This relates to hierarchical pseudo-random number generation for use in computer simulations that operate across more than one computing machine.

Abstract: A vehicle coordination system is provided for coordinating the trajectories of vehicles on a road network. The vehicle coordination system comprises a plurality of vehicles each having respective vehicle position tracking assemblies that are in communication with respective vehicle communication systems for transmitting vehicle state messages including positions of the vehicles. A task assignment allocator is provided that is arranged to generate task assignments for each of the plurality of vehicles, including destinations in the road network for the vehicles. A vehicle coordination assembly is in communication with the vehicle communication systems via a data network for receiving the vehicle state messages.

Abstract: A welded structural assembly and method, in one form, includes an upper substrate, a lower substrate adjacent the upper substrate, a fastener, and a sealing member. The fastener includes a shank portion, a first head portion, and a second head portion. The shank portion extends through the upper substrate and into the lower substrate. The shank is welded to the lower substrate. The first head portion has an outer periphery and an underside. The second head portion is frangibly coupled to the first head portion. The sealing member is disposed under the first head portion between the upper substrate and the first head portion. The sealing member contacts the underside and extends beyond the outer periphery such that the sealing member extends radially outward beyond all points of the first head portion.

Abstract: A lift device includes a chassis, a platform configured to support a user, a lift assembly coupling the platform to the chassis, an actuator configured to at least one of (a) move the platform relative to the chassis or (b) propel the chassis, a sensor assembly, and a controller. The sensor assembly includes a rod including a first end portion coupled to the platform and a second end portion opposite the first end portion, a housing defining an aperture sized to receive the second end portion of the rod, and a sensor coupled to the housing and configured to provide a signal in response to the second end portion of the rod exiting the aperture. The controller is operatively coupled to the sensor and the actuator and configured to control the actuator in response to receiving the signal from the sensor.

Abstract: A lift device includes a chassis, a platform configured to support a user, a lift assembly coupling the platform to the chassis, an actuator configured to at least one of (a) move the platform relative to the chassis or (b) propel the chassis, a sensor assembly, and a controller. The sensor assembly includes a bar including a first end portion coupled to the platform and a second end portion opposite the first end portion and a housing defining an aperture sized to receive the second end portion of the bar. The sensor provides a signal in response to at least one of (a) the second end portion of the bar contacting the sensor or (b) the second end portion of the bar exiting the aperture. The controller is operatively coupled to the sensor and the actuator and configured to control the actuator based on the signal from the sensor.

Abstract: A medical apparatus and method of operating a medical apparatus are disclosed. The apparatus includes a radiation source for emitting electromagnetic radiation towards one or both eyes of a patient; wherein the apparatus is configured to emit electromagnetic radiation having a ratio of scotopic luminous intensity to photopic luminous intensity of at least 1.85:1.

Abstract: An aircraft includes an airframe with first and second wings having a fuselage extending therebetween. A propulsion assembly is coupled to the fuselage and includes a counter-rotating coaxial rotor system that is tiltable relative to the fuselage to generate a thrust vector. First and second yaw vanes extend aftwardly from the fuselage. A flight control system is configured to direct the thrust vector of the coaxial rotor system and control movements of the yaw vanes. In a VTOL orientation of the aircraft, differential operation of the yaw vanes and/or differential operations of first and second rotor assemblies of the coaxial rotor system provide yaw authority for the aircraft. In a biplane orientation of the aircraft, collective operation of the yaw vanes provides yaw authority for the aircraft.

Abstract: This invention relates to using topological analysis of a graph representing a multi agent computer simulation in order to allocate agents to a multiprocessing computer system so as to optimize the calculation of the simulation.

Abstract: Method for identifying a subset of cells from a dataset for targeted gene expression analysis, comprising: defining an expected total recovered cell count for a barcode dataset; determining a region of interest for the total recovered cell count by calculating a lower bound for the region; and (b) calculating an upper bound for the region of interest by including an additional subset of barcodes having molecule counts below the lower bound; fitting the barcode dataset to a model; wherein the model groups barcodes as a function of molecule count; identifying a cut-off value on the model, wherein all barcodes having a molecule count above the cut-off value are called as cells; and identifying a targeted subset of cells from the called cells for conducting targeted gene expression, wherein a cell qualifies as part of the targeted subset if the cell has a molecule count above a target threshold.

Abstract: In one aspect, a method for filtering out erroneous sequence reads from a genomic sequence dataset, is disclosed. The genomic sequence dataset is received by one or more processors. The dataset is comprised of a plurality of fragment sequence reads, each with an associated barcode sequence and a unique identifier sequence. A threshold value for filtering out select fragment sequence reads from the genomic sequence dataset is determined by the one or more processors. The threshold value is a number of fragment sequence reads in the genomic sequence dataset with the same unique identifier sequence. Fragment sequence reads with the same unique identifier sequence occurring at less than the threshold value in the genomic sequence dataset is filtered out by the one or more processors. A filtered genomic sequence dataset is generated by the one or more processors.