Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: An automotive air control valve comprises a housing, the housing defining an air flow path, a blade pivotally mounted within the housing, the blade pivotable between a closed position, wherein the blade substantially blocks air flow through the housing, and an open position, wherein air can flow through the housing, an actuator adapted to selectively pivot the blade between the open and closed positions, a first stop that provides a positive stop for the blade when rotated to the open position, a second stop that provides a positive stop for the blade when rotated to the closed position; and an over-center cam mechanism, wherein the over-center cam mechanism is adapted to bias the blade in the open position when the blade has been pivoted to the open position, and to bias the blade in the closed position when the blade has been pivoted to the closed position.

Abstract: The present invention is a throttle body assembly which is adaptable for both gasoline and diesel applications, and may also be used for applications to meter fluid, such as for a water cooling valve. The throttle body assembly includes at least one bearing assembly and at least one seal which is used to configure the bearing assembly to withstand a high-pressure environment.

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —NR9—, —O— or —S— linkages, R2 is —YC(R4)(R5)CO2R6; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.

Abstract: A disposable wipes package and a package for disposable wipes comprising improved fitments to aid removal of wipes from within a package is disclosed herein. The dispensing fitment is formed of a single material and comprises a frame for securing to a package of disposable wipes. The frame has an oval, rectangular, diamond or ring shaped rim with an internal wall defining an opening through which wipes may be dispensed. A first petal is provided having a free end extending into an opening from a first side of the frame. A second petal has a free end extending into an opening from a second side of the frame towards the first petal to define a gap between the free ends of the first and second petals. The opening includes the gap and one or more orifices and occupies between 40% and 90% of the area within the rim.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: Disposable wipes packages containing improved opening and closing arrangements are disclosed. The packages are targeted for usage by adult caregivers and can provide reduced waste in comparison to some currently marketed wipe packages. Different forms of the packages disclosed herein include ratios of characteristics of the package closure fitments and those of the package body of wipes contained therein.

Abstract: A composite stiffener for a stiffener reinforced panel is disclosed. The stiffener has a longitudinal direction and a run-out region which terminates at an end of the stiffener. The stiffener also has a constant section region inboard of the run-out region in the longitudinal direction and having a constant cross section transverse to the longitudinal direction with a crown between adjacent foot portions. The run-out region has a changing cross section transverse to the longitudinal direction with a crown between adjacent foot portions and the crown reduces in height towards the end of the stiffener forming a ramp. The composite stiffener includes a number of blankets of non-crimp fabric layers.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: A traction kite anchor device has a base provided at an end of at least one kite line and a release member able to move relative the base by a hand of a user of the kite. A trip arm is pivotally connected to the base to move between a first rotational position relative the base and a second rotational position relative to the base. The trip arm carries a latch that can lock and release a catch of a chicken loop upon moving the release member relative the base.

Abstract: A traction kite anchoring device for attachment to a harness worn by a user to transfer force from a traction kite to the user. The traction kite anchoring device comprising a first member at an end of at least one line connected to a said kite and a chicken loop for attachment to a said harness and releasably connected to said first member, wherein the chicken loop has a first end comprising an anchor able to be received and secured at an anchor receiver of the first member in a releasable and tool-less manner.

Abstract: A medical fluid treatment system includes a source of purified water; at least one concentrate for mixing with the water from the source to form a treatment fluid; a disposable set including a pumping portion, a concentrate line in fluid communication with the concentrate source and the pumping portion, and a patient line in fluid communication with the pumping portion, the patient line including a filter having a membrane configured to filter the treatment fluid, the filter configured such that (i) fresh treatment fluid flowing from the pumping portion towards a patient flows through the membrane and (ii) used treatment fluid flowing through the filter from the patient to the pumping portion bypasses the membrane; and a medical fluid delivery machine including a pump actuator operable with the pumping portion of the disposable set.

Abstract: A disposable wipes package and a package for disposable wipes comprising improved fitments to aid removal of wipes from within a package is disclosed herein. The dispensing fitment is formed of a single material and comprises a frame for securing to a package of disposable wipes. The frame has an oval, rectangular, diamond or ring shaped rim with an internal wall defining an opening through which wipes may be dispensed. A first petal is provided having a free end extending into an opening from a first side of the frame. A second petal has a free end extending into an opening from a second side of the frame towards the first petal to define a gap between the free ends of the first and second petals. The opening includes the gap and one or more orifices and occupies between 40% and 90% of the area within the rim.

Abstract: There is provided a network device comprising at least one processor, and a memory storing instructions which when executed by the at least one processor configure the processor to perform a method. The method comprises segmenting packets of an original data stream into at least two partial data streams, and transmitting the at least two partial data streams to a downstream receiver configured to consolidate the at least two partial data streams based on the sequence numbers of the original data stream to reconstruct the original data stream. Each of the at least two partial data streams has an identifier in a header. The at least two partial data streams maintain sequence numbers of the original data stream.

Abstract: Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —NR9—, —O— or —S— linkages, R2 is —YC(R4)(R5)CO2R6; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.

Abstract: A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: An adapter assembly connected to a throttle body housing of an electronic throttle control assembly with a connecting feature. The adapter assembly of the present invention provides significantly lower cost assembly, and permits single side molding of the adapter assembly. The adapter assembly also includes alternative features for a captured seal or a void to contain excess thread sealer, and also permits a an anti-rotation feature, or locking tab, that is indexed to the receiving element, where the screw stop angle of the adapter assembly does not have to be controlled to provide a desired tab orientation.