Abstract: Disposable wipes packages containing improved opening and closing arrangements are disclosed. The packages are targeted for usage by adult caregivers and can provide reduced waste in comparison to some currently marketed wipe packages. Different forms of the packages disclosed herein include ratios of characteristics of the package closure fitments and those of the package body of wipes contained therein.

Abstract: An excentric pin for an electronic throttle control assembly, which is used to adjust the default position of at least one spring used to control the position of a valve plate, where the valve plate is located in an opening of a housing in the electronic control assembly. The excentric pin is used to adjust the default angle of the valve plate to have an angular tolerance of +/?0.10°. The excentric pin is slideably pressed into an aperture of the housing of the electronic throttle control assembly, and turned using some type of driver. The electronic throttle control assembly may be a one-spring design, or a two-spring design, where the two-spring design requires only one spring pin and the excentric pin. Also, the excenter pin may be used to adjust the position of the sector gear, e.g., function as the lower mechanical stop to provide a minimum opening angle for low leakage, and a minimum opening angle to avoid throttle plate corking into opening of the housing.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: A network system, switch controller for multicast packet distribution by controlling a network switch having at least one ingress interface and at least one egress interface.

Abstract: A series of substituted 3,4-di-hydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A network system, switch controller for multicast packet distribution by controlling a network switch having at least one ingress interface and at least one egress interface.

Abstract: Disclosed are systems and methods of adjusting the playing orientation of the head of a golf club. An adjustment to the axis of the shaft in reference to the vertical plane is constrained within minimum and maximum limits, so as to conform to current and proposed changes to the United States Golf Association (USGA) rules of play. The fine adjustment within these constraints cannot be readily made, and all adjustable parts are firmly fixed, so there is no reasonable likelihood of them working loose during a round. The adjustments to the club are designed such that during a stipulated round, the playing characteristics of a club cannot be purposely changed by adjustment or by other means.

Abstract: The present invention is a throttle body assembly which is adaptable for both gasoline and diesel applications, and may also be used for applications to meter fluid, such as for a water cooling valve. The throttle body assembly includes at least one bearing assembly and at least one seal which is used to configure the bearing assembly to withstand a high-pressure environment.

Abstract: An excentric pin for an electronic throttle control assembly, which is used to adjust the default position of at least one spring used to control the position of a valve plate, where the valve plate is located in an opening of a housing in the electronic control assembly. The excentric pin is used to adjust the default angle of the valve plate to have an angular tolerance of +/?0.10°. The excentric pin is slideably pressed into an aperture of the housing of the electronic throttle control assembly, and turned using some type of driver. The electronic throttle control assembly may be a one-spring design, or a two-spring design, where the two-spring design requires only one spring pin and the excentric pin. Also, the excenter pin may be used to adjust the position of the sector gear, e.g., function as the lower mechanical stop to provide a minimum opening angle for low leakage, and a minimum opening angle to avoid throttle plate corking into opening of the housing.

Abstract: A throttle body assembly includes a housing defining a throttle bore with a throttle plate in the bore and mounted on a shaft. An electric motor has a pinion gear. A gear assembly includes an intermediate gear and a sector gear and transfers rotational drive from the electric motor to the throttle plate. Biasing structure biases the sector gear and thus the shaft to cause the throttle plate to close the throttle bore defining a closed position thereof. When the motor is energized, rotation of the pinion gear causes rotation of the gear assembly, against the bias on the sector gear, thereby causing rotation of the shaft to move the throttle plate from the closed position to an open position. A position sensor assembly determines a position of the plate.

Abstract: A throttle body assembly includes a housing defining a throttle bore with a throttle plate in the bore and mounted on a shaft. An electric motor has a pinion gear. A gear assembly transfers rotational drive from the electric motor to the throttle plate. Biasing structure biases the gear assembly and thus the shaft to cause the throttle plate to close the throttle bore defining a closed position thereof. When the motor is energized, rotation of the gear assembly, against the bias biasing structure, thereby causing rotation of the shaft to move the throttle plate from the closed position to an open position. A position sensor assembly determines a position of the plate.

Abstract: A series of benzimidazole derivatives, being potent modulators of human TNF? activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Abstract: A throttle body assembly includes a housing defining a throttle bore with a throttle plate in the bore and mounted on a shaft. An electric motor has a pinion gear. A gear assembly includes an intermediate gear and a sector gear and transfers rotational drive from the electric motor to the throttle plate. Biasing structure biases the sector gear and thus the shaft to cause the throttle plate to close the throttle bore defining a closed position thereof. When the motor is energized, rotation of the pinion gear causes rotation of the gear assembly, against the bias on the sector gear, thereby causing rotation of the shaft to move the throttle plate from the closed position to an open position. A position sensor assembly determines a position of the plate.

Abstract: An adapter assembly connected to a throttle body housing of an electronic throttle control assembly with a connecting feature. The adapter assembly of the present invention provides significantly lower cost assembly, and permits single side molding of the adapter assembly. The adapter assembly also includes alternative features for a captured seal or a void to contain excess thread sealer, and also permits a an anti-rotation feature, or locking tab, that is indexed to the receiving element, where the screw stop angle of the adapter assembly does not have to be controlled to provide a desired tab orientation.

Abstract: Disclosed are systems and methods of adjusting the playing orientation of the head of a golf club. An adjustment to the axis of the shaft in reference to the vertical plane is constrained within minimum and maximum limits, so as to conform to current and proposed changes to the United States Golf Association (USGA) rules of play. The fine adjustment within these constraints cannot be readily made, and all adjustable parts are firmly fixed, so there is no reasonable likelihood of them working loose during a round. The adjustments to the club are designed such that during a stipulated round, the playing characteristics of a club cannot be purposely changed by adjustment or by other means.

Abstract: A glove can be used for preventing contamination when removed. The glove is configured to accommodate a user's hand and includes a tab extending from an edge of the glove proximate to an opening in the glove. The tab includes an outer border smoothly joined to an inner tab; wherein the outer border is thicker than the inner tab.

Abstract: A method of creating a CPAP mask assembly, that makes use of a CPAP mask, including a rigid portion adapted to connect to an air-delivery hose and to provide structure and a pliable, soft, face-contacting portion, supported by the rigid portion. Also utilized is a mask cover, having an annular piece of bio-compatible, absorbent material, having an outer edge and an inner edge that defines a plain opening and an elastic loop attached about the outer edge, thereby causing the outer edge to retract inwardly. The elastic loop is then placed over the mask so that the material covers the face-contacting portion and the opening is positioned centrally. Then the elastic loop is released, permitting it to retract inwardly so that part of the rigid portion is interposed between the elastic loop and the inner edge, thereby retaining the mask cover about the rigid portion of the mask, without deforming the face-contacting portion.

Abstract: Disclosed are systems and methods of adjusting the playing orientation of the head of a golf club. An adjustment to the axis of the shaft in reference to the vertical plane is constrained within minimum and maximum limits, so as to conform to current and proposed changes to the United States Golf Association (USGA) rules of play. The fine adjustment within these constraints cannot be readily made, and all adjustable parts are firmly fixed, so there is no reasonable likelihood of them working loose during a round. The adjustments to the club are designed such that during a stipulated round, the playing characteristics of a club cannot be purposely changed by adjustment or by other means.