Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

Abstract: In some embodiments, an apparatus includes a catheter having a catheter body, a light emitter disposed at a distal end of the catheter body, and a fluid conduit coupleable to a source of fluid. The fluid conduit configured to discharge fluid from the source via the conduit and out a distal end of the catheter body. A spacing member is disposed at the distal end of the catheter body and can be moved between a collapsed configuration and an expanded configuration. In the expanded configuration, the spacing member is disposed about the light emitter. The spacing member is at least partially transmissive and/or transflective of light emitted from the light emitter. The apparatus configured to be inserted at least partially into a body lumen, to discharge fluid into the body lumen, and to emit light from the light emitter to illuminate an interior wall of the body lumen.

Abstract: A computer-based method for determining a value of an index-offset deposit product, having a principal amount, a term, a specified guaranteed amount, and an index credit comprising the step of setting trial values for fixed-income-linked crediting parameters for the product implying an expected fixed-income-linked credit component at the end of the term. The method further comprises the steps of determining a cost for an option paying an index-linked credit component such that a composite index credit together with the principal is at least equal to a specified guaranteed amount.

Abstract: A computer-based method for determining a value of an index-offset deposit product, having a principal amount, a term, a specified guaranteed amount, and an index credit comprising the step of setting trial values for fixed-income-linked crediting parameters for the product implying an expected fixed-income-linked credit component at the end of the term. The method further comprises the steps of determining a cost for an option paying an index-linked credit component such that a composite index credit together with the principal is at least equal to a specified guaranteed amount.

Abstract: A computer-based method for determining a value of an index-offset deposit product, having a principal amount, a term, a specified guaranteed amount, and an index credit comprising the step of setting trial values for fixed-income-linked crediting parameters for the product implying an expected fixed-income-linked credit component at the end of the term. The method further comprises the steps of determining a cost for an option paying an index-linked credit component such that a composite index credit together with the principal is at least equal to a specified guaranteed amount.

Abstract: A computer-based method for determining a value of an index-offset deposit product, having a principal amount P, a term T, a specified guaranteed amount G, and an index credit C, comprising: d) setting trial values for fixed-income-linked crediting parameters for said product implying an expected fixed-income-linked credit component F at the end of the term T; e) determining a cost for an equity option paying equity-linked credit component E such that the index credit C=E+F, to be paid at T, together with the principal P, is at least equal to G; and f) summing said equity option cost, present value of principal, and present value of fixed-income-linked credit component to determine said value of said index-offset deposit product.

Abstract: A positive stop clamp for clamping a cross tube of a tie rod to a tie rod end includes a one-pieced clamp body having a U-shape cross section and a locking fastener. The clamp body includes two flat ends, each end having a pair of inwardly bent ears whereby a substantially circular interior is defined. The body further includes a cantilevered locator tab having a flange at its end. The flange abuts the end of the cross tube to locate the clamp at the desired point on the tube.

Abstract: A method of lining an existing pipe by pulling through it a collapsible, flexible, lay-flat liner having an innermost layer of impervious, elastomeric material which is compatible with the fluid to be carried by the pipe, a textile reinforcing intermediate layer, and an external protective layer of elastomeric material. The liner has an external circumference slightly less than the internal circumference of the pipe and is such that flow of fluid through the liner after the installation thereof expands the liner into non-binding contact with the internal surface of the pipe. The peripheral extension (diametral swell) of the liner at the intended working pressure of the relined pipe should be less than 10% and preferably less than 5%.

Abstract: In a ball and socket joint comprising a ball and a socket in mutual swivelling sliding engagement with each other, the ball having a stud integrally formed at one end thereof and projecting outwardly through one end of the socket, the improvement consisting in forming the socket with an annular groove circularly disposed at the edge of the open end of the socket for fitting and retaining therein the beaded end of a flexible oil-resistant seal having a bellows type body provided at one end with an annular band stretched over the periphery of the stud.

Abstract: In the formation of the components of a jig for profile stitching of garment parts, a profile formed in one component is used to create associated profiles in a second component and subsequently one of the associated profiles of the second component is used to create a related profile in the first component.

Abstract: In a ball and socket joint comprising a ball and a socket in mutual swivelling sliding engagement with each other, the ball having a stud integrally formed at one end thereof and projecting outwardly through one end of the socket, the improvement consisting in forming the socket with an annular groove circularly disposed at the edge of the open end of the socket for fitting and retaining therein the beaded end of a flexible oil-resistant seal having a bellows type body provided at one end with an annular band stretched over the periphery of the stud.

Abstract: In a method of and apparatus for top stitching parallel to the edge of a garment panel in which edge is a corner, there are provided means for detecting the approach of the corner and thereupon reducing the speed of movement of the panel through the machine and means acting on the underside of the panel to impart a turning motion thereto.