Abstract: Provided herein are compositions that include at least two different nucleic acid vectors that, when introduced into a primate cell, the at least two different vectors undergo con catamerization or homologous recombination with each other, thereby forming a recombined nucleic acid that encodes a full-length target protein (e.g., a supporting cell target protein or a hair cell target protein). Also provided are compositions that include a single AAV vector that, when introduced into a primate cell, a nucleic acid encoding a full-length target protein (e.g., a supporting cell target protein or a hair cell target protein) is generated at the locus of the supporting cell target gene, and the primate expresses the target protein (e.g., a supporting cell target protein or a hair cell target protein).

Abstract: The present disclosure provides thirteen synthetic peptides which have been shown to be FGF18 agonists. These synthetic peptides and topical compositions for decreasing, eliminating, or suppressing hair growth are disclosed herein. Methods for reducing hair growth, improving the appearance of skin, kits, and related cosmetic formulations are also provided herein.

Abstract: Compositions and topical formulations comprising a PPAR agonist complex comprising glyceryl linoleate, glyceryl linolenate, xymenynic acid, and Pterocarpus marsupium bark extract are described herein. Methods of inducing skin barrier repair, increasing the biosynthesis of barrier lipids and proteins in the skin, stimulating hair growth, treating acne and combinations thereof utilizing the composition and topical formulations are also provided herein.

Abstract: Provided herein are compositions that include one or more adeno-associated virus (AAVs) vectors and methods of inducing differentiation of a hair cell using these vector(s).

Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

Abstract: Aspects of the disclosure include a power system comprising at least one three-wire active harmonic filter (AHF) configured to be coupled to, and provide compensation current to, a three-phase load, at least one four-wire AHF configured to be coupled to, and provide compensation current to, the three-phase load, and a controller configured to determine a total compensation current to provide to the three-phase load, the total compensation current including a zero component and a non-zero component, determine an output capacity of the at least one three-wire AHF and the at least one four-wire AHF, calculate a current-compensation ratio based on the output capacity of the at least one three-wire AHF and the at least one four-wire AHF, and control the at least one four-wire AHF to provide at least a portion of the non-zero component of the total compensation current to the three-phase load based on the current-compensation ratio.

Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

Abstract: The compositions of various embodiments include a tocopherol phosphate mixture (TPM) comprising a liposome having a lipid bilayer and an internal aqueous compartment, a lipophilic ingredient, a polar solvent system, an alcohol, a base, and a water soluble phase, wherein the liposome is made of a tocopherol phosphate derivative, wherein the lipophilic ingredients are entrapped in the lipophilic bilayer of the liposome, and wherein a water soluble ingredient is dissolved in the water soluble phase and is in the internal compartment of the liposome. The methods include improving the look of skin particularly of the neck and décolletage, increasing expression of an extracellular matrix proteins in skin, improving a keloid scar in a subject, and improving aging skin. Additionally, methods for preparing said compositions are described herein.

Abstract: Disclosed herein are methods, an apparatus, and a computer-readable medium product for sharing broadcast resources and validating usage of the broadcast resources according to an agreement between a plurality of broadcast virtual network operators (BVNOs). A method includes determining the plurality of spectrum resources corresponding to a length of a broadcast frame, and creating a plurality of physical layer pipes (PLPs) based on a plurality of internet protocol (IP) flows from the plurality of BVNOs. The method includes constructing the broadcast frame including the plurality of PLPs and generating a broadcast frame record based on transmission of the broadcast frame. The broadcast frame record can identify the plurality of spectrum resources shared between the plurality of BVNOs. The method includes updating the broadcast frame record with identification information of the plurality of BVNOs and the plurality of IP flows corresponding to the plurality of PLPs of the broadcast frame.

Abstract: The present disclosure relates to a material handling system for manipulating items. The material handling system includes a repositioning system comprising a robotic tool which includes a robotic arm portion and an end effector. The robotic tool is configured to manipulate an item in a first orientation and reorient the item to a second orientation. The material handling system further includes a vision system having one or more sensors positioned within the material handling system. The vision system is configured to generate inputs corresponding to the characteristics of the items. The material handling system may further include a controller executing instructions to cause the material handling system to identify the item in the first orientation, based on the one or more characteristics of the item, initiate, by the repositioning system, picking of the item in the first orientation, and re-orient the item in the second orientation.

Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.