Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.

Abstract: Provided herein are compositions that include a single nucleic acid vector or two different nucleic acid vectors, and the use of these compositions to treat hearing loss and/or vision loss in a subject.

Abstract: Identification of augmented features based on a Bayesian analysis of a text document is disclosed. One example is a system including a document processing module, a feature processing module, and a feature generation module. The document processing module receives a text document via a processor. The feature processing module automatically identifies, based on a Bayesian analysis of the text document, a plurality of augmented features in the text document, the plurality of augmented features including at least one of local, sectional, and document-level features of the text document, and extracts, via the processor, the identified plurality of augmented features from the text document. The feature generation module generates, via the processor, a feature representation of the text document based on the extracted plurality of augmented features.

Abstract: Aspects of the invention include a continuous availability for workload and site switches with no data loss at unlimited distances in an active-active sites configuration. A non-limiting example computer-implemented method includes synchronously replicating commit records of changed workload data, by a processor, from an active site to a bunker site upon a workload data commit. The method asynchronously replicates committed transactions on changed workload data, by the processor, from the bunker site to a recovery site.

Abstract: Systems and methods for relaying in broadcast single-frequency networks are disclosed herein. A single-frequency network can be formed in part using transmitters that receive data via a cooperative relay channel instead of a station-to-transmitter link. In some embodiments, a second channel may use a portion of its transmission time to relay the information to the single-frequency network transmitter using time-division multiplexing. In other embodiments, a second channel may encode the relayed information on a second layer using layer-division multiplexing.

Abstract: Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.

Abstract: Systems and apparatuses include an alternator and a gearbox. The alternator includes an alternator housing defining an alternator flange, a rotor and stator positioned within the alternator housing, an alternator shaft coupled to the rotor for rotation about a central axis, and a first alternator bearing positioned distal from the alternator flange and supporting the alternator shaft. The gearbox includes a gearbox housing including a first flange structured to rigidly couple to an engine, and a second flange structured to rigidly couple to the alternator flange, an input shaft rotatable about the central axis, a gearbox bearing coupled to the gearbox housing and supporting the input shaft, an epicyclic gear train, and an output plate coupled to the epicyclic gear train and the alternator shaft.

Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.

Abstract: Various example embodiments described herein relates, to an item manipulation system that can include a control system and an end effector. The end effector can include a tube defining a channel between a first end and a second end. The tube can include, a flexible suction cup that can be disposed within the channel of the tube. In some examples, the flexible suction cup can engage a surface of the item based on suction force generated through the flexible suction cup. The end effector also includes a linear actuator that can be mechanically coupled to the flexible suction cup. The end effector can be configured to: extend, the flexible suction cup towards the second end of the channel to position at least a portion of the flexible suction cup outside the tube and retract, the flexible suction cup within the channel to position the flexible suction cup within the tube.

Abstract: Disclosed herein are methods, an apparatus, and a computer-readable medium product for sharing broadcast resources and validating usage of the broadcast resources according to an agreement between a plurality of broadcast virtual network operators (BVNOs). A method includes determining the plurality of spectrum resources corresponding to a length of a broadcast frame, and creating a plurality of physical layer pipes (PLPs) based on a plurality of internet protocol (IP) flows from the plurality of BVNOs. The method includes constructing the broadcast frame including the plurality of PLPs and generating a broadcast frame record based on transmission of the broadcast frame. The broadcast frame record can identify the plurality of spectrum resources shared between the plurality of BVNOs. The method includes updating the broadcast frame record with identification information of the plurality of BVNOs and the plurality of IP flows corresponding to the plurality of PLPs of the broadcast frame.

Abstract: The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

Abstract: According to one aspect of the disclosure, a power filter is provided including a first input configured to receive measurements of electrical characteristics of source power lines from a power source, a second input configured to receive measurements of electrical characteristics of load power lines to a load, an output configured to couple to output power lines to provide output current compensation signals, a power converter coupled to the power output and configured to receive input power, receive input control signals and provide the output current compensation signals based on the input control signals, and a controller configured to provide the control signals to the power converter, wherein the controller receives an indication of a neutral current limit, and the controller is configured to adjust the control signals based on the indication of the neutral current limit to limit current on a neutral of the output power line.

Abstract: The present invention is directed to Compounds of Formula (I) and salts thereof, wherein R1, R2, R3 and R4 are defined above herein. The present invention is also directed to uses of the compounds of Formula (I) to add phosphoramidate groups onto organic alcohols.

Abstract: Aspects of the present disclosure are directed to a power filter comprising a first input configured to receive measurements of electrical characteristics of source power lines from a power source, a second input configured to receive measurements of electrical characteristics of load power lines to a load, an output configured to couple to output power lines to provide output current compensation signals, a power converter coupled to the power output and configured to receive input power, receive input control signals and provide the output current compensation signals based on the input control signals, and control circuitry coupled to the first input, the second input and the power converter and configured to provide the control signals to the power converter, wherein the control circuitry is configured to detect a connection status of a neutral connection to the load, wherein the connection status includes one of connected and disconnected.

Abstract: According to one aspect of the disclosure, a power filter is provided including a first input configured to receive measurements of electrical characteristics of source power lines from a power source, a second input configured to receive measurements of electrical characteristics of load power lines to a load, an output configured to couple to output power lines to provide output current compensation signals, a power converter coupled to the power output and configured to receive input power, receive input control signals and provide the output current compensation signals based on the input control signals, and a controller configured to provide the control signals to the power converter, wherein the controller receives an indication of a neutral current limit, and the controller is configured to adjust the control signals based on the indication of the neutral current limit to limit current on a neutral of the output power line.

Abstract: A material handling system comprising one or more sub-systems and one or more sensing panels is provided. Each sensing panel may determine whether a mode control token is within a vicinity of the respective sensing panel. When the mode control token is within the vicinity of the respective sensing panel, the sensing panel may generate a signal, and when the mode is outside of the vicinity of the respective sensing panel, the generation of the signal is halted. The material handling system may further include a processor that enables at least one of the one or more sub-systems of the material handling system in response to the generated signal and disables each of the one or more sub-systems of the material handling system in response to a halting of the generation of the signal.

Abstract: Systems and apparatuses include an alternator and a gearbox. The alternator includes an alternator housing defining an alternator flange, a rotor and stator positioned within the alternator housing, an alternator shaft coupled to the rotor for rotation about a central axis, and a first alternator bearing positioned distal from the alternator flange and supporting the alternator shaft. The gearbox includes a gearbox housing including a first flange structured to rigidly couple to an engine, and a second flange structured to rigidly couple to the alternator flange, an input shaft rotatable about the central axis, a gearbox bearing coupled to the gearbox housing and supporting the input shaft, an epicyclic gear train, and an output plate coupled to the epicyclic gear train and the alternator shaft.