Abstract: The present disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air (way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ.

Abstract: A cocrystal having the formula LiX·aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.

Abstract: Interfaces for positive pressure therapy having a mask assembly, a headgear assembly and a connection port assembly are disclosed herein. The connection port assembly has a ball joint connection with the mask assembly and includes a quick release button for easily disconnecting the gases source conduit from the mask assembly. The mask assembly may include a bias flow vent that is formed separately and attached to the mask assembly. The headgear assembly encircles the rear region of the user's head and may include at least some portions that are substantially non-stretchable.

Abstract: Disclosed is a method and apparatus for digital control of a milling machine drum to minimize road material milled using complex geometry. A digital representation of a surface and/or subsurface of a road is loaded into a controller. Road defects are identified based on the digital surface, by comparing defect digital characteristics with the digital surface. A minimum removal map can be generated using the defect digital characteristics. A milling tool path can then be generated to minimize material removal, based on the minimum removal map. The mill depth and movement of a mill drum can then be controlled based on the milling tool path.

Abstract: A conduit for a breathing circuit includes a heater associated, at least in part, with a hydrophilic layer. The purpose of the heater is to evaporate any condensed liquid collecting in the conduit, which is first sucked up by the hydrophilic layer. The heated wick reduces the risk of collected water being passed to the patient and causing choking fits or discomfit. It is preferred that the heated wick lies freely in the conduit to settle at low points in the conduit where condensation may collect.

Abstract: An adjustable part-manufacturing tool and associated systems and methods are disclosed. The adjustable part-manufacturing tool includes a part-receiving receptacle defined by at least a first side and a second side. A first locating detail, including a first locating surface, is movably coupled to the tool body along the first side so that the first locating surface is selectively movable within the part-receiving receptacle in first opposing directions. A second locating detail, including a second locating surface, is movably coupled to the tool body along the second side so that the second locating surface is selectively movable within the part-receiving receptacle in second opposing directions. The second opposing directions are angled relative to the first opposing directions. Selective movement of the first locating surface and the second locating surface accommodates locating parts of different sizes on the first locating surface and the second locating surface within a specified tolerance.

Abstract: The present disclosure generally relates to methods and systems for generating a void profile for user void events. The method includes receiving by a processing element a plurality of outputs from a fluid level sensor corresponding to a plurality of levels of fluid flowing through a voiding device during a flow event; determining by the processing element a beginning and an end time of the fluid flow into the voiding device during the flow event; analyzing the plurality of outputs of the fluid level sensor over a time interval defined by the beginning and end time of the fluid flow to determine at least one of a fluid flow rate data and an accumulated volume data for the fluid flowing through the voiding device; and storing the fluid flow rate data and the accumulated flow volume data in a memory.

Abstract: The present invention relates to stable and low viscosity liquid pharmaceutical compositions comprising antibodies binding to human alpha synuclein and to methods for use of antibodies binding to human alpha synuclein for treating synucleinopathies or prodromal synucleinopathy, incl. suitable doses and/or dosing regimens. These antibodies for use in treatment of synucleinopathies or prodromal synucleinopathy may be formulated in the stable and low viscosity liquid pharmaceutical compositions of the invention.

Abstract: A controller for LiDAR sensor is programmed to activate a plurality of light emitter pairs each including a first light emitter and a second light emitter by alternating between a first powering sequence and a second powering sequence. The first powering sequence includes sequentially activating the first light emitters. The second powering sequence includes sequentially activating the second light emitters. The controller is programmed to, during one of the first powering sequences, detect damage to the first light emitter of a damaged one of the light emitter pairs. The controller is programmed to, during subsequent first powering sequences, activating the second light emitter of the damaged one of the light emitter pairs in response to detected damage to the first light emitter of the damaged one of the light emitter pairs.

Abstract: A formulation of a single phase solution, including aminopenicillin, a stabilizing agent, and water. The aminopenicillin in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including amoxicillin, ampicillin, and/or a combination thereof, a stabilizing agent, and water. The amoxicillin, ampicillin, and/or a combination thereof in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including amoxicillin, a stabilizing agent, and water. The amoxicillin in the solution has a potency of 87% or higher at 24 hours of storage at room temperature. A formulation of a single phase solution, including ampicillin, a stabilizing agent, and water.

Abstract: A respiratory mask can include one or a plurality of force sensors configured to detect a force imparted to a user's skin. Output from the one or more sensors can be represented in a way useful to the patient or healthcare provider for adjusting the mask to achieve a desired fitment. A representation of the detected forces can be displayed on a separate display device or on the mask.

Abstract: A dynamic asphalt paver comprising a plurality of gates for distributing the asphalt on the surface of the sub-base, at least one memory, and at least one processor communicatively coupled to the memory(s) and the gates. Each gate is configured to independently change the position relative to the surface and distribute asphalt on the surface based on the position. The processor(s) is configured to: receive a digital model of a portion of the sub-base that is to be paved that includes a plurality of cells that correspond to the portion of the sub-base; compare each cell of the digital model to a corresponding desired cell of a plurality of desired cells of a desired digital model of the portion of the sub-base; and adjust a position of each gate in response to comparing each cell of the digital model to a corresponding desired cell of the desired digital model.

Abstract: Various control methods can indirectly determine incorrect connections between components in a respiratory therapy system. For example, errors in the connections can occur between a patient interface, a humidifier and/or a gases source. The methods can indirectly detect if a reverse flow condition exists or other error conditions. A reverse flow condition can occur when gases flows in a direction different from an intended direction of flow. The detection of the reverse flow condition can be indicative of likely errors in connections between the humidifier, patient interface and/or gases source.

Abstract: An apparatus or kit for a respiratory support system for delivering humidified gas to a user or patient. The apparatus comprising a humidifier chamber in pneumatic communication with a gases source, an inspiratory conduit in pneumatic communication with the humidifier chamber downstream of the humidifier chamber, a filter that is in pneumatic communication with the inspiratory conduit downstream of the inspiratory conduit, and a patient interface for delivering humidified gas to a user or patient, wherein the patient interface is in pneumatic communication with the filter downstream of the filter, or is configured to be placed in pneumatic communication with the filter downstream of the filter.

Abstract: A patient interface, including a mask assembly and a headgear assembly, provides improved facial sealing and improved ease of use. The mask assembly includes an inflating or ballooning seal. The seal can be secured between two portions of a snap-fit exoskeleton. The headgear assembly connects to the mask assembly with flexible straps during course fitting and with more rigid straps following course fitting. The straps include holes that fit over a tapering post on the mask assembly.

Abstract: Patient interface components and/or associated head gear and adjustment systems improve sealing and/or patient comfort and/or ease of use. The interface includes an inflating or ballooning seal. The headgear assembly can be connected to the interface with an elastic component and an inelastic component. The elastic component enabling a course fitting of the interface to the patient and the inelastic component enabling a final fitting of the interface to the patient.

Abstract: A respiratory assistance system including a humidification apparatus used for delivery of heated and humidified gases to a patient includes a humidification chamber with an associated heater and sensor, an inspiratory conduit with an associated heater and sensor, and an unheated patient interface, such as a face mask. A controller of the humidification apparatus is configured to determine a gas source and change the set point accordingly to maintain patient comfort regardless of the humidity level of the gas source.

Abstract: A method of hand sanitation and a hand sanitation device for applying sanitation fluid to a user's hand. The method has the steps of: providing an apparatus having a volume with a cavity for placement of at least one hand, and at least one nozzle configured for spraying inside the volume; providing sanitation fluid in fluid communication with the at least one nozzle; and spraying an amount of the sanitation fluid on at least two areas on the dorsal side of a hand positioned in the volume, the at least two areas being the outside of the hand and the fingertips.

Abstract: An apparatus and method for constraining access to memory using capabilities. Processing circuitry performs operations during which access requests to memory are generated, with memory addresses for the access requests being generated using capabilities that identify constraining information. Capability checking circuitry performs a capability check operation to determine whether a given access request whose memory address is generated using a given capability is permitted based on the constraining information. Memory access checking circuitry then further constrains access to the memory by the given access request in dependence on a level of trust. The given capability has a capability level of trust associated therewith, and the level of trust associated with the given access request is dependent on both the current mode level of trust associated with the current mode of operation of the processing circuitry, and the capability level of trust of the given capability.

Abstract: A LiDAR system includes a light detector having a field of view, a beam-steering device, and a light emitter aimed at the beam-steering device. The beam-steering device is aimed to emit light from the light emitter into a field of illumination overlapping the field of view. The beam-steering device includes two beam-steering stages each having a polarization grating. The polarization gratings are designed to diffract light from the light emitter based on the polarization state of the light received by the polarization grating. The beam-steering device includes a switchable polarization selector designed to change the polarization state of the light to move the field of illumination relative to the field of view.