Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: A LiDAR system includes alight emitter, a light detector, and a controller. The controller is programmed to: activate the light emitter to emit a series of shots into a field of view of the light detector; activate the light detector to detect shots reflected from an object in the field of view; determine the size of a subset of the series of shots to be recorded based on a distance of the object from the light detector; and record the subset of the series of shots.

Abstract: Interfaces for positive pressure therapy having a mask assembly, a headgear assembly and a connection port assembly are disclosed herein. The connection port assembly has a ball joint connection with the mask assembly and includes a quick release button for easily disconnecting the gases source conduit from the mask assembly. The mask assembly may include a bias flow vent that is formed separately and attached to the mask assembly. The headgear assembly encircles the rear region of the user's head and may include at least some portions that are substantially non-stretchable.

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract: Systems and methods to perform remote monitoring on a vehicle are described. One embodiment determines a state of a vehicle, where data associated with the vehicle is collected and logged. The data is transmitted to a data server. The data is processed, and vehicle information is extracted from the data. A state of the vehicle is determined based on the vehicle information.

Abstract: Apparatus comprises a processor to execute program instructions stored at respective memory addresses, processing of the program instructions being constrained by a prevailing capability defining at least access permissions to a set of one or more memory addresses; the processor comprising: control flow change handling circuitry to perform a control flow change operation, the control flow change operation defining a control flow change target address indicating the address of a program instruction for execution after the control flow change operation; and capability generating circuitry to determine, in dependence on the control flow change target address, an address at which capability access permissions data is stored; the capability generating circuitry being configured to retrieve the capability access permissions data and to generate a capability for use as a next prevailing capability in dependence upon at least the capability access permissions data.

Abstract: There is provided a data processing apparatus comprising a plurality of registers, each of the registers having data bits to store data and metadata bits to store metadata. Each of the registers is adapted to operate in a metadata mode in which the metadata bits and the data bits are valid, and a data mode in which the data bits are valid and the metadata bits are invalid. Mode bit storage circuitry indicates whether each of the registers is in the data mode or the metadata mode. Execution circuitry is responsive to a memory operation that is a store operation on one or more given registers.

Abstract: A system and method for determining location information of a portable device relative to an object is provided. In one embodiment, a booking control system is provided for booking a resource or service associated with the object. The system and method may determine location information with respect to the portable device, and identify the user as checked-in or checked-out (e.g., the resource is in-use or out of use) based on the location information.

Abstract: A packaging film is described comprising at least one polymer film layer in which particles of a small-pore or a medium-pore palladium-doped zeolite are dispersed. Such films are of particular utility for the adsorption of volatile organic compounds, such as those originating from organic matter.

Abstract: A focal-plane array includes an array of pixels. Each pixel includes an avalanche-type diode on a first layer, a read-out circuit (ROIC) on a second layer, and a power-supply circuit on a middle layer stacked between the first layer and the second layer. Since each pixel includes the avalanche-type diode, the ROIC, and the power-supply circuit on different layers circuitry for each pixel is in a top-down footprint of the pixel. Thus a consistent bias voltage to each pixel, decouples the avalanche-type diodes of the different pixels to eliminate crosstalk between adjacent pixels, and allows for individual control of each pixel.

Abstract: A customizable mask including a conforming seal is configured to utilize the physical process of granular jamming to enable it to adapt to a wide range of facial geometries. The mask may include a frame having a perimeter and a conduit connection, a conforming seal positioned along the perimeter of the frame. The conforming seal may include a sealing surface and a connecting surface, the connecting surface configured to mate with the perimeter of the frame, and the sealing surface configured to conform to a users' face. The conforming seal may further include an outer casing, granular material contained within the outer casing, and a vacuum connection. The mask may also include a similarly configured conforming frame. Further disclosed are methods of forming such masks.

Abstract: A patient interface, including a mask assembly and a headgear assembly, provides improved facial sealing and improved ease of use. The mask assembly includes an inflating or ballooning seal. The seal can be secured between two portions of a snap-fit exoskeleton. The headgear assembly connects to the mask assembly with flexible straps during course fitting and with more rigid straps following course fitting. The straps include holes that fit over a tapering post on the mask assembly.

Abstract: The use of a palladium-doped zeolite for the adsorption of volatile organic compounds is described wherein the zeolite has a CHA framework type and is polymer-bound. Such zeolites have been found to have particular utility as packaging materials for the adsorption of volatile organic compounds, such as those originating from organic matter.

Abstract: The test lab set-up includes a test flow bench for mounting one or more test devices, an adjustable nozzle for simulating urine flow, and a sensor for collecting data associated with the simulated urine flowing through the test device(s). A computing device for measuring and/or calculating various parameters associated with the simulated urine flow may also be included. The test device may have a shape corresponding to a handheld uroflowmeter subject to testing. The angle of the adjustable nozzle may be adjusted to test for various angles of urine flow. Similarly, the angle, pitch, and roll of the test device may be adjusted to test for various angles at which a uroflowmeter is held. As fluid flows through the test device, the sensor collects information such as, for example, flow rate, duration, volume, and the like. The sensor transmits the data collected to a computing device for additional processing.

Abstract: A method, computer program product, and system to perform a sale transaction are provided. The method includes identifying each item of a plurality of items, based on at least one image of the plurality of items, determining a cost for each item, optionally identifying a person based on an image of the person, adding each of the items and each of the costs to a sale transaction, and charging the person for the sale transaction.

Abstract: Systems and methods for network optimization using end user telemetry are disclosed. In one embodiment, a method for optimizing incoming communication routing may include: (1) establishing, by a data center computer program executed by a data center computer processor, a data connection with an end user electronic device, the data connection using a first data communication route; (2) collecting, by the data center computer program, a metric for the data connection; (3) determining, by the data center computer program, that the metric is outside of an acceptable range; (4) determining, by the data center computer program, that a cause for the metric being outside of the acceptable range is external to the data center; and (5) re-routing, by the data center computer program, the data connection to a second data communication route.

Abstract: A system and method for determining location information of a portable device relative to an object is provided. In one embodiment, a booking control system is provided for booking a resource or service associated with the object. The system and method may determine location information with respect to the portable device, and identify the user as checked-in or checked-out (e.g., the resource is in-use or out of use) based on the location information.

Abstract: A system and a method to wirelessly synchronize, monitor, or communicate, or a combination thereof, amongst sensors (e.g., sensors, hubs, sensor controllers, etc.) in a Bluetooth Low Energy-based microlocation system. The system or method, or both, may use the BLE hardware (e.g., transmitters, receivers, antennas, etc.) to interleave a communications protocol within the connection interval gaps of the BLE protocol used to communicate with devices.