Abstract: Provided herein are compositions and methods to treat lysosomal storage disorders. In particular, provided herein are compositions, methods, kits and uses for inhibition or modification of soluble CD22 (sCD22) and its ligand interactions as therapeutic targets in lysosomal storage disorders including Niemann-Pick Disease Type C.

Abstract: Implementations disclosed herein provide a charging station configured to attach to or be positioned adjacent to a wall in a confinement institution and to simultaneously charge multiple tablets, mobile phones, laptops, or other portable electronic devices. In some implementations, the charging station is configured with protective sides that may help protect inserted electronic devices from damage. The charging and use of the electronic devices within the confinement institution may be automatically managed based connections at the charging stations, communications with the electronic devices, audio, images, or video of the electronic devices or users captured cameras on the charging station or the electronic devices, and/or information provided by the users.

Abstract: Implementations disclosed herein provide a charging station configured to attach to or be positioned adjacent to a wall in a confinement institution and to simultaneously charge multiple tablets, mobile phones, laptops, or other portable electronic devices. In some implementations, the charging station is configured with protective sides that may help protect inserted electronic devices from damage. The charging and use of the electronic devices within the confinement institution may be automatically managed based connections at the charging stations, communications with the electronic devices, audio, images, or video of the electronic devices or users captured cameras on the charging station or the electronic devices, and/or information provided by the users.

Abstract: A process for making a sintered article including the steps of: (a) preparing a particulate mixture; (b) contacting the particulate mixture to water to form a humidified mixture; (c) pressing the humidified mixture to form a green article; (d) optionally, subjecting the green article to an initial drying step; (e) subjecting the green article to a firing step in a kiln to form a hot fused article; and (f) cooling the hot fused article to form a sintered article. The particulate mixture includes: (i) at least 20 wt % coarse coal combustion fly ash; and (ii) at least 30 wt % clay, wherein the coarse coal combustion fly ash has a particle size in the range of from greater than 150 ?m to less than 250 ?m.

Abstract: A porous refractory article including greater than 90 wt % coal combustion fly ash. The coal combustion fly ash is in the form of an interconnected particulate lattice structure, and wherein greater than 50% by volume of the coal combustion fly ash particles within the particulate lattice structure have a particle size of greater than 150 ?m. The article has: (a) an apparent porosity of from 30% to 50%, (b) a porosity such that the maximum pore size is less than 500 ?m; (c) a cold crushing strength of at least 4.0 MPa; and (d) a thermal conductivity of less than 1.5 W/(m·K).

Abstract: A refrigeration assembly includes a receiver tank, a heat exchanger, a first piping assembly, and a second piping assembly. The receiver tank has a fluid outlet and a fluid inlet that receives a working fluid. The heat exchanger is disposed within the receiver tank. The heat exchanger has coiled tubing that is fluidly coupled to the fluid inlet and to the fluid outlet. The first piping assembly is disposed between and is fluidly coupled to the fluid inlet and the coiled tubing. The first piping assembly has a first double riser and a first P-trap. The second piping assembly is disposed between and is fluidly coupled to the fluid outlet and the coiled tubing. The second piping assembly includes a second double riser and a second P-trap.

Abstract: Systems and methods interacting with tabletop models are provided herein. A display system includes a tabletop model, including a horizontal display that is configured to display a two-dimensional digital map and a three-dimensional physical model that is configured to overlay the two-dimensional digital map. The display system includes a mobile device including a camera configured to generate a camera image. The mobile renders a model image of the three-dimensional digital and overlays a camera image of the tabletop model with the model image. The mobile device determines a selection of an object based on a touch position on the model image.

Abstract: The oscillating fishing lure is a fishing lure comprising: a body with a longitudinal axis, an uppermost surface, at least one hook, said first hook including a shank and a hook end, said shank being coupled to said body; a blade having an edge proximal to said body, wherein, during retrieval, a majority of said blade is oriented below said uppermost surface of said body; a joining mechanism whereby said blade is moveably coupled to said body, wherein said blade has freedom to move with respect to the roll, pitch and yaw axis only within strict mathematical limits; a line attachment mechanism, through which a fishing line is attached to the lure; and whereby retrieval of the lure causes the blade to oscillate in at least one dimension, and thereby causing the lure to erratically hunt. The oscillating-blade action imparts a natural swimming motion to the lure, emulating prey-species movements.

Abstract: Systems and methods interacting with tabletop models using a handheld device are provided herein. A display system includes a tabletop model, including a horizontal display that is configured to display a two-dimensional digital map and a three-dimensional physical model that is configured to overlay the two-dimensional digital map. The display system includes a mobile device including a touchscreen display. The display system transforms a movement on the touchscreen display to a movement of a cursor on the two-dimensional digital map.

Abstract: An example method for visual testing and issue communication of programmed display of content includes obtaining a workflow of test scenarios for visual testing a display. The content displayed on the display is controlled by a set-top box (STB) device executing target instructions. The example method further includes identifying a visual testing issue associated with executing the test scenarios, and communicating the workflow and issue to a remote device for reproduction of the issue.

Abstract: The invention relates to an MRI apparatus and a method of MRI involving the acquisition of a first and a second MRI image with mutually different orientations between the BO magnetic field and the object to be investigated. For instance, when imaging structures such as a tendon, due to the magic angle effect, this results in a change in image contrast. According to the invention, a coregistration can be performed between the first and the second MRI image. Moreover, the orientation of a structure within the object can be determined on the basis of the different orientations and the image intensity in the first and the second MRI image. The invention further discloses an apparatus for carrying out the method and a method of shimming the BO magnetic field of the apparatus.

Abstract: A method for controlling a package delivery sorting system onboard a vehicle includes loading, onboard a package sorting platform, a first package comprising a first fiducial marker, the package sorting platform disposed in a cargo hold of the package delivery vehicle, determining, via a processor, a package identity based on the first fiducial marker, determining, via the processor and based on the fiducial marker, a first package pose comprising a first package position and a first package orientation with respect to the package sorting platform, defining, via the processor, a first package geometry associated with the first package, and causing the sorting platform to position the first package, via the processor, to a second first package pose.

Abstract: A method for controlling a package delivery sorting system onboard a vehicle includes loading, onboard a package sorting platform, a first package comprising a first fiducial marker, the package sorting platform disposed in a cargo hold of the package delivery vehicle, determining, via a processor, a package identity based on the first, fiducial marker, determining, via the processor and based on the fiducial marker, a first package pose comprising a first package position and a first package orientation with respect to the package sorting platform, defining, via the processor, a first package geometry associated with the first package, and causing the sorting platform to position the first package, via the processor, to a second first package pose.

Abstract: The disclosure describes systems and methods including for monitoring and remotely controlling a fleet of autonomous vehicles. The remote vehicle control system determines a control input to control a vehicle based on an action performed on or with a controller bot. The controller bot is configured for use on a horizontal display that displays a map and a vehicle graphic at a location on the map.

Abstract: The fishing lure includes a jig body, a blade, and a pin structure. The jig body includes a longitudinal axis, a connector, and at least one hook including a shank and a hook end, the shank being surrounded by and protruding rearwardly from the jig body. The blade has an edge proximal to the jig body, wherein the blade includes first and second members on the edge proximal to the jig body, each member defining a chamber. The pin structure is coupled to the blade via the first and second members, the pin structure including a midsection between opposing first and second pin ends, wherein the midsection of the pin structure engages the connector of the jig body while the pin structure passes through the first and second members of the blade. Retrieval of the fishing lure causes the blade to oscillate.

Abstract: A process for preparing a granular ceramic mixture includes the steps of: (a) contacting fluid bed combustion fly ash with an acidic aqueous solution to obtain acidic fluid bed combustion fly ash slurry; (b) removing excess acid from the slurry obtained in step (a) to obtain solid acid treated fluid bed combustion fly ash; and (c) contacting together: (i) the solid acid treated fluid bed combustion fly ash obtained in step (b); (ii) clay; (iii) optionally, feldspar; and (iv) optionally, other ingredients.

Abstract: Systems and methods navigating a digital map are provided herein. A method includes displaying a plurality of clusters. Each cluster includes a plurality of page icons and each page icon linking to a page. The method includes receiving a control input to move a page icon from a first one of the clusters to a second one of the clusters.

Abstract: Implementations disclosed herein provide user interfaces that are configured to selectively use and present device and system resources in ways that motivate inmate engagement with self-administered courses. One example of this is a user interface that is provided with music enabling capabilities as a reward to motivate course engagement. The user interface presents a segment of course material of one or more self-administered courses and the app determines an engagement score indicating a level of engagement by the inmate with the segment of the course material. The app determines that the inmate qualifies for a music reward based on the engagement score satisfying reward criteria, and accordingly displays, on the user interface, a notification of the music reward and/or enables music on the inmate device, for example, during display of a second segment of the course material.

Abstract: Systems and methods interacting with tabletop models using a handheld device are provided herein. A display system includes a tabletop model, including a horizontal display that is configured to display a two-dimensional digital map and a three-dimensional physical model that is configured to overlay the two-dimensional digital map. The display system includes a mobile device including a touchscreen display. The display system transforms a movement on the touchscreen display to a movement of a cursor on the two-dimensional digital map.

Abstract: Systems and methods of transcutaneously stimulating one or more peripheral nerves of a patient with a wearable neurostimulation device regulated by a measured rhythmic biological signal to treat a patient are disclosed, and can include measuring a rhythmic biological signal of the patient and determining one or more features of the measured rhythmic biological signal of the patient in real-time; delivering a first electrical nerve stimulation signal transcutaneously to the first peripheral nerve effector to stimulate the first peripheral nerve sufficient to modify a first neural circuit to modulate nervous system activity of the patient at least in part based on the measured rhythmic biological signal; and delivering a second electrical nerve stimulation signal transcutaneously to the second peripheral nerve effector to stimulate the second peripheral nerve sufficient to modify the first or a second neural feedback loop to modulate nervous system activity of the patient at least in part based on the measured