Abstract: The present invention provides devices suitable for filtration including diafiltration of a suspension containing a species such as particles, cells or macromolecules, apparatus comprising such devices and methods of using the devices and apparatus. The devices of the invention comprise a vessel having a filter that divides the vessel into a first chamber and a second chamber provided with various outlet ports. Gas is used to finally concentrate the suspension (118) in the filtration chamber by displacing the liquid up to 95% through the filter (14).

Abstract: The present invention provides devices, apparatus and systems suitable for achieving volume reduction in a liquid containing a species in suspension and methods of use thereof. The apparatus of the invention comprises (i) a filter device comprising: a tubular first chamber having a filter provided in a surface thereof, a second chamber in fluid communication with the first chamber through the filter, the device being provided with an inlet port opening to the first end of the first chamber, an outlet port opening to the second end of the first chamber, and a filtrate port opening to the second chamber, and (ii) a fluidic pathway from the outlet port, wherein the apparatus is configured to introduce the first liquid and a second fluid immiscible with the first to the first chamber and the apparatus comprises a flow cut-off means in the fluidic pathway from the outlet port.

Abstract: An interactive device that is an accessory to a flush toilet and is positioned at the rear of the flush toilet and may be attached to the rear of the toilet such that the user would use the flush toilet in the reverse position. The interactive device may include a toy, game, or computer. The interactive device may be secured to the toilet by straps or to the toilet lid hinges and may be detachable from the flush toilet. The interactive device may have hinges that allow the interactive device to be folded to a compact configuration. The interactive device makes “going to the bathroom” enjoyable for both the child and parent, while educating the child to appreciate and to become more accustomed to using a flush toilet.

Abstract: The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of such solid forms for the therapeutic treatment of warm-blooded animals.

Abstract: A system that allows a user to create a lineup of alternatives as controls for a part of a 3D scene by selecting scene contents and designating a lineup alternative control to contain or receive the contents. Once the alternatives are created, the lineups are provided in a graphical user interface (GUI) that displays each alternative as a compressed image of the scene containing the corresponding alternative. The user can click between the alternatives by selecting a desired button so that only the alternative selected in that lineup is shown in the scene. The user can create multiple lineups, each for a different part or overlapping parts of the scene, for changing the materials in a scene, and/or for positioning objects in a scene.

Abstract: Plural modes of operation may be established on a mobile device. Specific modes of operation of the mobile device may be associated with specific spaces in memory. By associating the existing certificate store structure and key store structure with a mode of operation, certificates and keys can be assigned to one space among plural spaces. Furthermore, management (viewing/importation/deletion) of certificates associated with specific modes of operation may be controlled based on the presence or absence of a mobile device administration server and the status (enabled/disabled) of an IT policy.

Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

Abstract: An electromagnet comprising a ferromagnetic yoke which comprises a yoke. Mutually opposing first and second pole pieces are provided. The first pole piece is provided with a planar coil having a first side facing the yoke and a second side facing the yoke. A balancing member is arranged on the second side of the planar coil to counterbalance the attractive force between the planar coil and the yoke. The other pole piece may also be provided with a corresponding balancing member.

Abstract: This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salt(s) thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same.

Abstract: Four and a Half LIM domains protein 1 (FHL-1) mutations at positions 128 or 224 that are associated with X-linked muscular myopathy, methods of screening subjects to identify those susceptible to muscular myopathy including muscular dystrophy and cardiomyopathy and kits.

Abstract: This invention relates to safety anchors for roof workers and in particular to a gutter ladder anchor, a ridge anchor, a rafter anchor, and a truss anchor. In a one aspect the invention is a gutter ladder anchor formed from a metal plate, and comprising a flat base, having left, right, rear, and front ends; a fold at the front end of the base; one or more legs extending from the fold; a flange at the end of each leg, folded upwards; one or more holes located in each leg for mounting a vertical eye or a ladder location attachment; a first pattern of spaced apart holes through the base for fixing the anchor to a batten or purlin, said first pattern extending from the left end to the right end; and one or more holes through the flange of each leg for fixing the anchor to a gutter.

Abstract: This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salts thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same.

Abstract: Techniques for ver ring identity and/or location of a customer. One embodiment involves receiving a customer-provided address from a customer in a communication via a computer network or telephone network. The customer is a person or entity paying to receive calls from a resident of a controlled access residential institution. The embodiment further involves accessing a computer system to identify location information associated with the customer, the location information derived from additional information within or about the communication and determining a reliability estimate of the customer-provided address by comparing the customer-provided address with the location information associated with the customer that was identified based on the additional information. The embodiment may involve notifying a telecommunications provider, the controlled access residential institution, or law enforcement based on the reliability estimate of the customer-provided address.

Abstract: The present invention is an accessory to a flush toilet in which an interactive device is positioned at the rear of the flush toilet and may be attached to the rear of the toilet such that the user would use the flush toilet in the reverse position. The present invention may be an interactive device such as a toy/game or computer. The interactive device may be detachable from the flush toilet. The present invention may include a support arm connected to the interactive device and an insert configured to fit in a toilet bowl and connected to the other end of the support arm. The present invention may be folded for a compact configuration. The present invention makes “going to the bathroom” enjoyable for both the child and parent, while educating the child to appreciate and to become more accustomed to using a flush toilet.

Abstract: Four and a Half LIM domains protein 1 (FHL-1) mutations at positions 128 or 224 that are associated with X-linked muscular myopathy, methods of screening subjects to identify those susceptible to muscular myopathy including muscular dystrophy and cardiomyopathy and kits.

Abstract: The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of such solid forms for the therapeutic treatment of warm-blooded animals.

Abstract: A human machine interface enables human users to interact with a machine by inputting auditory and/or textual data. The interface and corresponding method perform efficient look up of words, corresponding to inputted human data, which are stored in a domain database. The robustness of a speech synthesis engine is enhanced by updating the deployed pronunciation vocabulary dynamically. The architecture of the preferred embodiment of the former method includes a combination of ensemble matching, clustering, and rearrangement methods. The latter method involves retrieving suggested phonetic pronunciations for words unknown to the speech synthesis engine and verifying those through a manual or autonomous process.

Abstract: A fluid composition comprises a base stock and a polymer. The base stock comprises a glycol, such as ethylene glycol. The polymer comprises the reaction product of a hydroxyl functional initiator, such as a diol, and alkylene oxides. The alkylene oxides are selected from the group of ethylene oxide (EO), propylene oxide (PO), and butylene oxide (BO). In certain embodiments, the alkylene oxides comprise EO and PO. The fluid composition provides a four-ball wear test scar of less than about 1 millimeter, generally under the following test conditions: 60 minutes run, 55° C., 1800 rpm, and 40 kg load. In other embodiments, the fluid composition comprises the polymer and is substantially free of the base stock. The fluid composition is useful for vibration dampening and can be used in vibration dampeners. The vibration dampener is useful for dampening vibrations between the two rigid components of the vehicle.

Abstract: A catcher bracket disposed between a powertrain and a sub-frame of a vehicle. The catcher bracket defines a load path in a collision that is sufficient to displace the powertrain that directs the force of the impact through the catcher bracket to a sub-frame of the vehicle. The sub-frame is connected to the body structure of the vehicle by fasteners that fracture to decouple the powertrain and sub-frame from the body structure of the vehicle to reduce the collision pulse.

Abstract: This invention relates to (1) process of making 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and salts thereof; (2) novel salt(s) of 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide; (3) pharmaceutical compositions comprising the same; and (4) methods of treatment using the same.