Abstract: The present disclosure relates to a razor cartridge which comprises a frame and one or more cutting members. The frame has a leading longitudinal member and a trailing longitudinal member. The one or more cutting members are arranged between the leading longitudinal member and the trailing longitudinal member. At least one magnetic element is configured and arranged to apply a magnetic field in a magnetic shaving aid comprising a magnetic surfactant and being applied to a skin surface so as to elicit an induced change in the magnetic shaving aid between a pre-shave state and a during-shave state.

Abstract: Technologies disclosed herein are directed to enforcing blocking functionality on a mobile device (e.g., a mobile device within a vehicle). The mobile device receives a request to disable a blocking of a user interaction with one or more functions of the mobile device. The mobile device prompts a capture of an image by a camera of the mobile device. The mobile device determines whether the image is captured from a passenger space in the vehicle. Once so determined, the mobile device disables the blocking of the user interaction with the one or more functions of the mobile device.

Abstract: Technologies disclosed herein are directed to context-based mobile device management. According to one embodiment, an application executing in a mobile device detects an event to trigger context-based management of the mobile device. A usage context associated with the mobile device is determined. One or more policies to enforce on the mobile device are identified as a function of the usage context. The application enforces the one or more policies on the mobile device.

Abstract: The invention relates to a process for making sodium-ion cells, particularly sodium-ion cells which are capable of safe storage and/or transportation, comprising the steps: a) constructing a sodium-ion cell comprising a positive electrode, a negative electrode and an electrolyte, optionally performing one more charge/discharge operations on the sodium-ion cell; and b) treating the sodium-ion cell to ensure that it is in a state of charge of from 0% to 20%.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A method is disclosed for controlling one or more appliances in a user environment, the one or more appliances in operation capable of causing environmental stimuli disruptive to a user's sleep. The method comprises receiving from one or more sensors data indicative of a sleep state of the user; analysing the received data to determine one or more control actions for controlling the one or more appliances to reduce sleep disruption due to the environmental stimuli caused by the appliances; and controlling the one or more appliances in dependence on the determined control actions. The method may involve determining, based on sleep state data for a first sleep period, an appliance control schedule for a second, later, time period.

Abstract: The invention is in the field of protein:protein interactions, in particular the stabilisation of protein:protein interactions. Binding proteins are provided for stabilising the interactions, together with compositions comprising the binding proteins. Methods using the binding proteins are also provided, including targeting of cells and also medical uses.

Abstract: Systems, methods, and devices for managing predetermined functions on a mobile device, the operating system (OS) installed on the device including an event application programming interface (API) configured to enable voice over internet protocol (VoIP) applications to assume priority over other applications and functions of the mobile device when VoIP calls are detected. A mobile device management software application installed and running on the mobile device emulates a VoIP software application and uses event API calls to trick the OS into believing that a VoIP call has been detected and, in response, causes the OS to block or interfere with one or more predetermined functions on the mobile device based on the status and location of the mobile device.

Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.

Abstract: The present disclosure relates to a duplex probe molecule comprising: i) a double-stranded-core (the core) comprising a first polynucleotide strand (first-strand) and a second polynucleotide strand (second-strand), wherein the first and second strands are complementary to each other, ii) a single stranded first polynucleotide probe (first probe) sequence extending in the 5? to 3? direction from the first-strand of the core; and iii) single stranded second polynucleotide probe (second probe) sequence extending in the 5? to 3? direction from the second strand of the core; wherein the first and second probes extend outwards from the double stranded core in opposing directions on different polynucleotide strands and each terminate in a 3? end. The disclosure also extends to methods of making the molecule and use of the molecule, for example to capture variable domains sequence information from antibodies.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A system and method are provided for warning of an exposure of a second individual to an allergen by transfer from a first individual. Movements of the individuals are tracked so that allergen types and levels to which the individuals have been exposed can be obtained. Using knowledge of user sensitivity information to different allergens, it is determined if the first individual has been exposed to allergen types and levels which pose a risk to the second individual by GPS transfer from the first individual to the second individual. Thus, action can be taken when there is a determined risk of allergen transfer between individuals.

Abstract: An air quality control system and method is provided, in which a humidity level is controlled in such a way as to reduce an amount of dust resuspension caused by occupant or device activities in an indoor space, and taking into account type of floor surface in that space.

Abstract: Systems, methods, and devices for managing predetermined functions on a mobile device, the operating system (OS) installed on the device including an event application programming interface (API) configured to enable voice over internet protocol (VoIP) applications to assume priority over other applications and functions of the mobile device when VoIP calls are detected. A mobile device management software application installed and running on the mobile device emulates a VoIP software application and uses event API calls to trick the OS into believing that a VoIP call has been detected and, in response, causes the OS to block or interfere with one or more predetermined functions on the mobile device based on the status and location of the mobile device.

Abstract: A method and system for determining a recommended level of exertion of an individual. A pollution level is identified and used to recommend a level of exertion that takes into account an amount of pollution inhaled by the individual.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: A safety assembly provided with an automatic fire extinguisher system includes an engagement member, a blocking member, and an extension member. The engagement member is slidably received within an outlet port of a valve housing. A blocking member having a first blocking member portion and a second blocking member portion is at least partially received within a cavity defined by the valve housing. The extension member extends between the engagement member and the blocking member.

Abstract: Systems and methods for adjusting bone cut positioning are disclosed that can aid in optimizing implant size selection and positioning relative to bone during, e.g., orthopedic surgical procedures such as knee arthroplasty, hip arthroplasty, etc. In one embodiment, such a surgical method can include performing a first bone cut of a first bone using an at least partially robot-assisted surgical instrument, detecting one or more parameters related to bone hardness, selecting a bone hardness index based on the one or more detected parameters, and adjusting a position of a second bone cut of the first bone based on the selected bone hardness index to optimize implant fit relative to bone. Detecting the one or more parameters related to bone hardness can be performed in a number of manners, including by monitoring energy required to perform the first bone cut.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: A computer-implemented method includes registering, by a mobile wallet computing system, a plurality of items to a master wallet held by a user, wherein the master wallet is associated with a mobile wallet on a user mobile device; registering one or more sub-wallets for the user, wherein each sub-wallet includes one or more of the items registered to the master wallet; and configuring one or more rules for each sub-wallet, wherein the one or more rules for a given sub-wallet define when the mobile wallet computing system provisions the given sub-wallet to the mobile wallet. The method also includes monitoring a context of the user; determining whether the one or more rules for each sub-wallet are fulfilled, based on the monitored context of the user; and in response to at least one rule associated with a predefined sub-wallet being fulfilled, provisioning the predefined sub-wallet to the mobile wallet.