Abstract: Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Abstract: A device for injecting fluid from a pre-filled cartridge is provided. The device includes a needle for piercing a patient. After an injection, the needle can be retracted to prevent inadvertent contact with the contaminated needle. A needle retainer releasably retains the needle in the retracted position. The needle can subsequently be re-extended to administer a subsequent injection. After the cartridge is emptied, the cartridge can be removed, if desired, and replaced with another cartridge for additional injections. Alternatively, the needle can be substantially permanently retracted into the device and safely disposed of in a sharps container.

Abstract: The present invention relates to a syringe (10) for administering injections of medicinal fluids to a patient or withdrawal of fluid, such as blood from a patient. More specifically the present invention is a syringe device (10) for injecting medication or withdrawing fluid, wherein after use the needle (60) is shielded (15) against inadvertent contact to prevent needle sticks.

Abstract: This invention relates to a novel safety shield for rotary drilling rigs. More particularly, the invention pertains to a portable, clam-shell style extendible leg safety shield which can be readily installed on the ground around the drill stem of an operational drilling rig, such as an oil well drilling rig. A safety shield for use in association with rotary drilling rigs comprising (a) a first protective shield; (b) a second protective shield hinged to the first shield; (c) a first leg assembly connected to the exterior of the first shield; (d) a second leg assembly secured to the exterior of the second shield; and (e) a securing mechanism for securing the first shield to the second shield.

Abstract: An apparatus and method for the magnetic-based, releasable and position adjustable attachment of an article to a support. The device is well suited for use with cameras, spotting scopes, navigational devices, distance finders, sensors, lights and other devices, but is not limited to use with these articles. Various embodiments are disclosed including several magnetic-based releasable attachment configurations, various positioning and position locking mechanisms, multiple ways to attach to an ancillary article, and anti-rotation mechanisms, among other aspects of the present invention.

Abstract: A walking staff apparatus having a tripod assembly that is releasably fastened to a main shaft. The tripod assembly may be released from the shaft to achieve a compact arrangement for transport or storage. The shaft may also be telescoping to achieve a compact size. The release joint may include a mechanism for centering the shaft and tripod assembly. A magnetic-based mechanism for releasable attachment of an article may be coupled to the shaft. The magnetic-based attachment mechanism may include an anti-rotation device to achieve secure positioning of an article releasable attached to the shaft.

Abstract: An alignment apparatus for use with the assembly of tubular segments with a tubular string in a well bore is disclosed. The alignment apparatus includes an actuator assembly functionally associated with an engagement assembly. Upon actuation of the actuator assembly, the engagement assembly engages the segment. The alignment apparatus is then lowered such that the segment contacts the string, and a connection may be made. A method of improving the alignment of the segment with the tubular string in the well bore is also is also disclosed.

Abstract: This invention concerns a juicer, that is a machine for extracting the juice from fruit and vegetables. Such machines are used domestically, and also commercially in restaurants, cafes and juice bars. The invention comprises an electric motor, a shredder mounted for rotation by the motor, a feed tube to deliver pieces to be juiced to the shredder for juicing, wherein the feed tube has an inner diameter of more than 75 mm, and three, or more, inwardly directed formations are arranged to constrict the interior of the feed tube. The inner diameter of the feed tube may be large enough for a typical apple to pass through it whole such as 85 mm or more. The inwardly directed formations serve to prevent the insertion of a hand or arm into or through the feed tube despite its large diameter.

Abstract: This invention relates to a novel safety shield for rotary drilling rigs. More particularly, the invention pertains to a portable, clam-shell style extendible leg safety shield which can be readily installed on the ground around the drill stem of an operational drilling rig, such as an oil well drilling rig. A safety shield for use in association with rotary drilling rigs comprising (a) a first protective shield; (b) a second protective shield hinged to the first shield; (c) a first leg assembly connected to the exterior of the first shield; (d) a second leg assembly secured to the exterior of the second shield; and (e) a securing mechanism for securing the first shield to the second shield.

Abstract: An adjustable infusion injection apparatus which is designed to be used in conjunction with a surgically implanted infusate injection port. The apparatus utilizes a catheter assembly and an introducer needle assembly. The catheter assembly is to be installed on the skin of the patient in alignment with the port and the introducer needle is to be inserted in conjunction with the catheter assembly to insert a catheter within an internal chamber of the port and then the introducer needle is then removed with the catheter to then be used to inject medication from an inlet tube. During installation a movable portion of said catheter assembly can be moved to abuttingly be in contact with the skin of the patient.

Abstract: A storage bin having a mechanism (2) for wrapping objects to be stored in the bin. The bin comprises two trays (4,5) configured to receive a roll of self-adhesive film (3). Two rollers (6,7) are rotated in an insertion direction (30) by a driving mechanism so as to cause an object (9) to pass between the rollers (6,7) into a container (1) as the object (9) becomes wrapped in the self-adhesive film (3).

Abstract: A device for injecting fluid from a pre-filled cartridge is provided. The device includes a needle for piercing a patient. After an injection, the needle can be retracted to prevent inadvertent contact with the contaminated needle. A needle retainer releasably retains the needle in the retracted position. The needle can subsequently be re-extended to administer a subsequent injection. After the cartridge is emptied, the cartridge can be removed, if desired, and replaced with another cartridge for additional injections. Alternatively, the needle can be retracted into the device and safely disposed of in a sharps container.

Abstract: A device is provided for injecting fluid from a pre-filled cartridge. The device includes a needle and a hollow barrel that holds a pre-filled cartridge. A needle retainer releasably retains the needle in an extended position so the needle can be inserted into a patient. A plunger in the rear of the barrel cooperates with the cartridge to expel fluid from the cartridge during an injection. After an injection, the needle is automatically retracted into the barrel when pressure is released from the plunger. A locking mechanism locks the contaminated needle and cartridge in the barrel after needle retraction. After use, the device may be safely disposed of in a sharps container.

Abstract: A method, an apparatus, and a computer program product for electromagnetically designing a shaped-reflector multibeam antenna (100) are disclosed. An initial configuration of the multibeam antenna (100) for given beam directions is provided of reflectors (110,120) shaped with an initial reflector shaping process (612) and feeds of an initial specification (614). The initial reflector shaping process (612) is an iterative optimization process for increasing the focusing of optical rays incident on the multibeam antenna from the given beam directions (100). A second iterative optimizing process consisting of optimizing (620) radiation patterns of feeds (140A-140D) and optimizing (622) surface shapes and sizes of reflectors (110,120) is used to reduce beam spillover, improve beam shapes and obtain beams with gain radiation patterns within required upper and lower bounds.

Abstract: The invention concerns the use of a compound of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, in the treatment of a disease or condition mediated by monocyte chemoattractant protein-1 (MCP-1). Certain of the components of formula (I) are novel and are provided, together with pharmaceutical compositions thereof, as further features of the invention.

Abstract: A staff apparatus having a leg assembly with multiple movable legs. In one embodiment, the leg assembly includes three legs to form a tripod. The staff apparatus may include an adaptable magnetic-based mount for releasably attaching a camera, spotting scope, gun or arm rest, or other item. The mount may be movable or non-movable. A shaft may include multiple telescoping sections, and an upper section may telescope into a lower section. Various embodiments and features of the staff apparatus are disclosed.

Abstract: A method and apparatus are provided for using a medical device (10) comprised of a medical apparatus (20) and a needle assembly (30). The needle assembly includes a needle (70) having a sharpened tip. Preferably, the medical apparatus (20) is a standard apparatus, such as a syringe or phlebotomy device. The medical apparatus (20) includes a connector (24), such as a Luer connector. The needle assembly (30) is configured so that it can be attached to the medical apparatus (20) and the sharpened tip of the needle (70) is automatically shielded after use to prevent inadvertent contact with the contaminated needle.

Abstract: An infusion device is provided for use with an intravenous catheter connected to a primary fluid supply. A Y site (92) is in fluid communication with the catheter (90). The infusion device is releasably connectable with the Y site (92) to connect a secondary fluid supply (97) to the catheter (40). The infusion device includes a retractable needle (70) that is retractable after use.

Abstract: The invention concerns quinazoline derivatives of the formula I wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); wherein Q1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q1 optionally bears up to 3 substituents; wherein m is 1 or 2 and each R1 may be a group such as hydrogen, halogeno and trifluoromethyl; and wherein Q2 may be phenyl or a 9- or 10-membered bicyclic heterocyclic moiety and Q2 optionally bears up to 3 substituents; or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.

Abstract: A bonding system is provided that bonds a heat sink to a printed circuit assembly. The bonding system includes an adhesive applicator that is configured to hold an adhesive layer, and a heat sink holder that is configured to hold a heat sink while the adhesive applicator applies the adhesive layer to the heat sink.