Abstract: A bone cutting guide may include a support that contains a shaft movable relative to the support. The shaft may carry a guide member having one or more cut guides through which a clinician inserts a cutting member to cut bone positioned under the guide cut guides. In operation, a clinician may fixate the support of the bone cutting guide to a bone and translate the guide member until the one or more cut guides are positioned at a desired cut location. The clinician may then perform a cut through the cut guide. In some examples, the bone cutting guide includes additional components, such as bridging member or secondary cut guide, to provide additional functionality.

Abstract: A technique for correcting a bone deformity, such as a bunion, may be performed using an instrument. In some examples, the technique involves inserting the instrument between a first metatarsal and a second metatarsal. The technique further includes preparing an end of the first metatarsal and preparing an end of a medial cuneiform opposing the end of the first metatarsal.

Abstract: The present invention relates to chimeric antigen receptors (CARs) directed to cells expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor. Further provided are methods of targeting neoplastic cells and tumours expressing a dysfunctional or non-functional P2X purinoceptor 7 receptor and methods of treating and preventing cancer is a subject.

Abstract: A filter arrangement for an aquarium is disclosed. The filter arrangement can include a filter housing assembly, a pump assembly, and a transfer tube assembly. In one aspect, the housing assembly and the pump assembly are separately constructed assemblies that are connected to each other via a first dampening member to prevent vibration and sound from being transmitted from the pump assembly to the filter housing assembly. The filter arrangement can further include a second dampening member connecting the pump assembly with the transfer tube assembly to further prevent vibration and sound from being transmitted from the pump assembly to the filter housing assembly. A third dampening member can be provided at a location where the transfer tube assembly is supported within the filter housing assembly to further isolate vibration and sound from being transmitted from the pump assembly to the filter housing assembly via the transfer tube assembly.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A bone positioning guide may include a main body member, a shaft, and a bone engagement member. The shaft can be movably connected to the main body member and have the bone engagement member rotatably coupled to its distal end. The bone engagement member can have a surface configured to engage a bone. The main body member can also include a tip opposite the bone engagement member for engaging a second bone. In use, the bone engagement member may be positioned in contact with a medial side of a first metatarsal while the tip is positioned in contact with a lateral side of a different metatarsal, such as a second metatarsal. The shaft can then be moved to advance the bone engagement member toward the tip, causing realignment of the first metatarsal.

Abstract: A driver socket for installation of a ground reinforcement bolt is provided. The driver socket includes a cylindrical tube having a longitudinal axis, wherein a leading end of the driver socket is configured to be arranged in connection to the bolt and a trailing end of the driver socket is configured to be arranged in connection to a driving device. The driver socket includes a through hole having. The through hole has a varying cross-sectional area along its axial length. The through hole has comprising a first diameter in a mid-section thereof that is smaller than a second diameter in a leading section thereof. The through hole has a transition located between the mid-section and the leading section. The transition has a frustoconical shape. An installation system including a ground reinforcement bolt and the driver socket is also provided.

Abstract: A drill string for rotary drilling of underground mining machines includes a first elongate drill string member and a second elongate drill string member. The first member has a main section and a male end, and the second member has a main section and a female end. The male and female ends each have respective threads to provide a thread coupling between the male and female ends, the thread coupling enabling the male end to be secured inside the female end such that the male and female ends overlap axially. A thread lead of the respective threads of the male and the female ends are greater than a diameter of the male end and the female end.

Abstract: Technologies for dynamically selecting resources for virtual switching include a computing device configured to identify a present demand on processing resources of the computing device that are configured to process data associated with network packets received by the computing device. Additionally, the computing device is configured to determine a present capacity of one or more acceleration resources of the computing device and configure the virtual switch based on the present demand and the present capacity of the acceleration resources. Other embodiments are described herein.

Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.

Abstract: Disclosed are example embodiments of a breathing exercise device. The breathing exercise device including a respiratory muscle training (RMT) device. The RMT device configured to communicatively connect to an electronic communication device. The RMT device further configured to measure biometric data of a user and transmit the biometric data of the user to the electronic communication device. The biometric data is transmitted while streaming at least one of instructional video content and instructional audio content to the electronic communication device.

Abstract: A user’s computing device (such as a smartphone) runs an application whereby the user can connect with nearby bystanders who may speak different languages. Upon establishing a connection with the bystander, the user can enter a message in the user’s primary language. The message is translated to the primary languages of the bystanders, and each such translated message is also back-translated into the user’s primary language for review and editing. The back-translated message(s) allow the user to discern possible issues with the original message that may cause misunderstandings with the bystanders. Subsequent editing of the original and/ or back-translated messages results in updates to all of the original, translated, and back-translated messages, and upon the user’s approval, the translated messages are sent to the bystanders, who may respond via their devices in the same manner as the user.

Abstract: The technologies described herein are generally directed toward shedding processing loads associated with route updates. According to an embodiment, a system can comprise a processor and a memory that can enable operations facilitating performance of operations including facilitating receiving, from a second routing device via a network, a communication. The operations can further comprise, in response to a queueing delay being determined to be less than a threshold, queueing, in the queue, the communication for a third routing device selected according to a first selection process as being on a route to a destination routing device for the communication. Further, operations to, in response to the queueing delay of the queue being determined to be equal to or above the threshold, transmit the communication to a fourth routing device, with the fourth routing device being selected according to a second selection process different than the first selection process.

Abstract: The technologies described herein are generally directed toward shedding processing loads associated with route updates. According to an embodiment, a system can comprise a processor and a memory that can enable operations facilitating performance of operations including facilitating identifying a route update for a route to a destination node on a network. Additional operations can include evaluating a value of the route update, resulting in an evaluated value of the route update. Additional operations can include determining whether to communicate the route update to a second routing device based on the evaluated value of the route update.

Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.

Abstract: There is disclosed a computing apparatus, including: a memory; a memory encryption controller to encrypt at least a region of the memory; and a network interface to communicatively couple the computing apparatus to a remote host; wherein the memory encryption controller is configured to send an encrypted packet decryptable via an encryption key directly from the memory to the remote host via the network interface, bypassing a network protocol stack.

Abstract: The technologies described herein are generally directed toward establishing a domain of authority for routing table updates from a routing device. According to an embodiment, a system can comprise a processor and a memory that can enable operations facilitating performance of operations including identifying a route update that comprises information about a network. According to the embodiment, the operations can further include communicating, via the network, the route update to a second routing device for propagation of the route update to routing devices in a first authority domain with the first routing device.

Abstract: In at least one embodiment, an audio amplifier system is provided. The system includes a loudspeaker and an audio amplifier. The loudspeaker transmits an audio output into a listening environment. The audio amplifier is programmed to receive an audio input signal and to generate an excursion signal corresponding to a first excursion level of the voice coil based on the audio input signal. The audio amplifier is further programmed to limit the excursion signal to reach a maximum excursion level and to determine a target pressure for an enclosure of the loudspeaker based on the maximum excursion level. The audio amplifier is further programmed to generate a target current signal based at least on the target pressure and to convert the target current signal into a target voltage signal to a target driving signal to drive the voice coil to reach the maximum excursion level.

Abstract: The technologies described herein are generally directed toward establishing a domain of authority for routing table updates from a routing device. According to an embodiment, a system can comprise a processor and a memory that can enable operations facilitating performance of operations including identifying a route update that comprises information about a network. According to the embodiment, the operations can further include communicating, via the network, the route update to a second routing device for propagation of the route update to routing devices in a first authority domain with the first routing device.

Abstract: A radiation shield assembly includes a shield configured to block radiation and a rail assembly configured to position the shield in between the radiation table and a radiation source. The shield is movable between a retracted position and an extended position along a length of the rail assembly. In the extended position, the shield extends along a portion of a radiation table and blocks radiation from the radiation source to the portion of the radiation table. In the retracted position, the shield exposes at least some of the portion of the radiation table to the radiation.